Selective Serotonin Reuptake Inhibitor; Antianxiety Drugs - name, MOA classification adverse effect therapeutic uses ; Antidepressants - classify, SSRI - therapeutic uses, adverse effects; Pethidine over Morphine - advantages; Morphine and other Opioids - moa,uses, adverse effect , Why is Morphine contraindicated in Head Injury; Acute Morphine Poisoning - treatment in detail; Opioids and NSAIDS - major differences depending on MOA, uses, adverse drug reactions; Opioid Antagonists - classify,moa, therapeutic uses, adverse effect ; Opium Alkaloids - enumerate, Morphine - MOA, adverse effects, clinical uses All answer in details for 2nd yr mbbs pharmacology refer kd tripathi all detail
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That's a complete, comprehensive pharmacology answer. Here's a quick orientation of what's covered:
What's Covered Above (Index)
| Section | Topics |
|---|---|
| Part 1 | Antidepressants - Full Classification (TCAs, SSRIs, SNRIs, MAOIs, Atypicals) |
| Part 2 | SSRIs - Detailed MOA, Therapeutic Uses (table), Adverse Effects (complete) |
| Part 3 | Antianxiety Drugs - Full Classification + Benzodiazepines (MOA, Uses, ADRs) + Buspirone |
| Part 4 | Opium Alkaloids - Phenanthrene vs Isoquinoline groups enumerated |
| Part 5 | Morphine - MOA (receptor-level + cellular), Clinical Uses, Adverse Effects + Why contraindicated in Head Injury (RSVP mnemonic) |
| Part 6 | Pethidine advantages over Morphine (comparison table + disadvantages of pethidine) |
| Part 7 | Acute Morphine Poisoning - Treatment in detail (Airway, Naloxone dosing, Supportive, GI decontamination, monitoring) |
| Part 8 | Opioids vs NSAIDs - Comprehensive comparison table (14 parameters) |
| Part 9 | Opioid Antagonists - Classification (Pure/Partial/Peripheral) + Naloxone + Naltrexone details |
Key points to remember for exam:
- SSRIs - "Frequency" of Cl- channel opening for BZDs; SSRIs work by SERT inhibition; full effect in 2-4 weeks due to autoreceptor downregulation
- Morphine in head injury - 4 reasons: CO2 retention → cerebral vasodilation → raised ICP; miosis masks herniation signs; sedation masks GCS; hypotension reduces CPP
- Naloxone - pure antagonist, IV, onset 1-2 min, duration 30-90 min (SHORTER than opioids - repeat doses needed)
- Opioids vs NSAIDs - Opioids: no anti-inflammatory, ceiling absent, dependence yes; NSAIDs: anti-inflammatory, ceiling present, no dependence
- Normeperidine (toxic metabolite of pethidine) - causes seizures NOT reversed by naloxone
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