from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.platypus import (
    SimpleDocTemplate, Table, TableStyle, Paragraph, Spacer,
    HRFlowable
)
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY
from reportlab.platypus import KeepTogether

OUTPUT = "/tmp/workspace/febrile-seizure-pdf/Febrile_Seizure_vs_Epilepsy_Paeds.pdf"

doc = SimpleDocTemplate(
    OUTPUT,
    pagesize=A4,
    rightMargin=1.8*cm, leftMargin=1.8*cm,
    topMargin=1.8*cm, bottomMargin=1.8*cm
)

# ── Colour palette ──────────────────────────────────────────────
BLUE_DARK   = colors.HexColor("#1a3a5c")
BLUE_MID    = colors.HexColor("#2e6da4")
BLUE_LIGHT  = colors.HexColor("#d6e8f7")
ORANGE      = colors.HexColor("#e05c2a")
GREEN_LIGHT = colors.HexColor("#e8f5e9")
AMBER_LIGHT = colors.HexColor("#fff3e0")
WHITE       = colors.white
GREY_LIGHT  = colors.HexColor("#f5f5f5")
GREY_ROW    = colors.HexColor("#eeeeee")
TEXT_DARK   = colors.HexColor("#1a1a1a")
RED_SOFT    = colors.HexColor("#fdecea")

# ── Styles ───────────────────────────────────────────────────────
styles = getSampleStyleSheet()

title_style = ParagraphStyle("title", fontName="Helvetica-Bold",
    fontSize=17, textColor=WHITE, alignment=TA_CENTER,
    leading=22, spaceAfter=4)

subtitle_style = ParagraphStyle("subtitle", fontName="Helvetica",
    fontSize=9, textColor=colors.HexColor("#cce0f5"), alignment=TA_CENTER,
    leading=12, spaceAfter=2)

section_head = ParagraphStyle("sechead", fontName="Helvetica-Bold",
    fontSize=11, textColor=WHITE, alignment=TA_CENTER, leading=14)

col_head = ParagraphStyle("colhead", fontName="Helvetica-Bold",
    fontSize=9.5, textColor=WHITE, alignment=TA_CENTER, leading=12)

row_label = ParagraphStyle("rowlabel", fontName="Helvetica-Bold",
    fontSize=8.5, textColor=BLUE_DARK, alignment=TA_LEFT, leading=11)

cell_style = ParagraphStyle("cell", fontName="Helvetica",
    fontSize=8.5, textColor=TEXT_DARK, alignment=TA_LEFT, leading=11)

cell_bold = ParagraphStyle("cellbold", fontName="Helvetica-Bold",
    fontSize=8.5, textColor=TEXT_DARK, alignment=TA_LEFT, leading=11)

note_style = ParagraphStyle("note", fontName="Helvetica-Oblique",
    fontSize=7.5, textColor=colors.HexColor("#555555"),
    alignment=TA_LEFT, leading=10, leftIndent=5)

box_head = ParagraphStyle("boxhead", fontName="Helvetica-Bold",
    fontSize=9, textColor=BLUE_DARK, alignment=TA_LEFT, leading=12)

box_body = ParagraphStyle("boxbody", fontName="Helvetica",
    fontSize=8.5, textColor=TEXT_DARK, alignment=TA_LEFT, leading=12)

footer_style = ParagraphStyle("footer", fontName="Helvetica-Oblique",
    fontSize=7, textColor=colors.HexColor("#888888"), alignment=TA_CENTER)

# ── Helper: build a table row ─────────────────────────────────────
def row(feature, febrile, epilepsy, shade=False):
    bg = GREY_ROW if shade else WHITE
    return ([
        Paragraph(feature, row_label),
        Paragraph(febrile, cell_style),
        Paragraph(epilepsy, cell_style),
    ], bg)

# ── Title block ───────────────────────────────────────────────────
def title_block():
    title_data = [[Paragraph("Febrile Seizure  vs  Epilepsy", title_style)],
                  [Paragraph("Paediatrics | MBBS Final Year Exam Reference  •  Based on Harrison's 22e, Adams & Victor 12e, Bradley & Daroff's Neurology, Rosen's Emergency Medicine", subtitle_style)]]
    t = Table(title_data, colWidths=[17.4*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0), (-1,-1), BLUE_DARK),
        ("TOPPADDING",  (0,0), (-1,-1), 8),
        ("BOTTOMPADDING",(0,0),(-1,-1), 6),
        ("LEFTPADDING", (0,0), (-1,-1), 10),
        ("RIGHTPADDING",(0,0), (-1,-1), 10),
        ("ROWBACKGROUNDS",(0,0),(-1,-1),[BLUE_DARK]),
    ]))
    return t

# ── Section header bar ────────────────────────────────────────────
def sec_bar(text, color=BLUE_MID):
    t = Table([[Paragraph(text, section_head)]], colWidths=[17.4*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0),(-1,-1), color),
        ("TOPPADDING", (0,0),(-1,-1), 5),
        ("BOTTOMPADDING",(0,0),(-1,-1), 5),
        ("LEFTPADDING",(0,0),(-1,-1), 8),
    ]))
    return t

# ── Main comparison table builder ────────────────────────────────
def comparison_table(rows_data):
    """rows_data: list of (feature, febrile_text, epilepsy_text)"""
    col_w = [4.2*cm, 6.6*cm, 6.6*cm]
    header = [
        Paragraph("Feature", col_head),
        Paragraph("Febrile Seizure", col_head),
        Paragraph("Epilepsy (Childhood)", col_head),
    ]
    table_data = [header]
    row_styles = []
    for i, (feat, feb, epi) in enumerate(rows_data):
        shade = (i % 2 == 0)
        bg = GREY_LIGHT if shade else WHITE
        table_data.append([
            Paragraph(feat, row_label),
            Paragraph(feb, cell_style),
            Paragraph(epi, cell_style),
        ])
        if shade:
            row_styles.append(("BACKGROUND", (0, i+1), (-1, i+1), bg))

    t = Table(table_data, colWidths=col_w, repeatRows=1)
    style = TableStyle([
        # Header
        ("BACKGROUND",     (0,0), (-1,0), BLUE_MID),
        ("TEXTCOLOR",      (0,0), (-1,0), WHITE),
        ("FONTNAME",       (0,0), (-1,0), "Helvetica-Bold"),
        ("FONTSIZE",       (0,0), (-1,0), 9.5),
        ("ALIGN",          (0,0), (-1,0), "CENTER"),
        ("VALIGN",         (0,0), (-1,-1), "TOP"),
        # Grid
        ("GRID",           (0,0), (-1,-1), 0.4, colors.HexColor("#b0b0b0")),
        ("LINEBELOW",      (0,0), (-1,0), 1.2, BLUE_DARK),
        # Padding
        ("TOPPADDING",     (0,0), (-1,-1), 5),
        ("BOTTOMPADDING",  (0,0), (-1,-1), 5),
        ("LEFTPADDING",    (0,0), (-1,-1), 5),
        ("RIGHTPADDING",   (0,0), (-1,-1), 5),
    ])
    for s in row_styles:
        style.add(*s)
    t.setStyle(style)
    return t

# ── Risk box / info boxes ─────────────────────────────────────────
def two_col_box(left_title, left_items, right_title, right_items,
                left_bg=GREEN_LIGHT, right_bg=AMBER_LIGHT):
    """Two side-by-side info boxes"""
    def make_cell(title, items, bg):
        content = [Paragraph(title, box_head)]
        for item in items:
            content.append(Paragraph(f"• {item}", box_body))
        cell_tbl = Table([[c] for c in content], colWidths=[7.9*cm])
        cell_tbl.setStyle(TableStyle([
            ("BACKGROUND", (0,0), (-1,-1), bg),
            ("TOPPADDING", (0,0),(-1,-1), 5),
            ("BOTTOMPADDING",(0,0),(-1,-1), 4),
            ("LEFTPADDING",(0,0),(-1,-1), 8),
            ("RIGHTPADDING",(0,0),(-1,-1), 6),
            ("BOX", (0,0),(-1,-1), 0.8, BLUE_MID),
        ]))
        return cell_tbl

    lc = make_cell(left_title, left_items, left_bg)
    rc = make_cell(right_title, right_items, right_bg)
    outer = Table([[lc, rc]], colWidths=[8.4*cm, 8.4*cm],
                  hAlign="CENTER")
    outer.setStyle(TableStyle([
        ("VALIGN", (0,0),(-1,-1), "TOP"),
        ("LEFTPADDING",(0,0),(-1,-1), 3),
        ("RIGHTPADDING",(0,0),(-1,-1), 3),
    ]))
    return outer

def single_box(title, items, bg=BLUE_LIGHT, border=BLUE_MID):
    content = [Paragraph(title, box_head)]
    for item in items:
        content.append(Paragraph(f"• {item}", box_body))
    t = Table([[c] for c in content], colWidths=[17.0*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0),(-1,-1), bg),
        ("TOPPADDING", (0,0),(-1,-1), 5),
        ("BOTTOMPADDING",(0,0),(-1,-1), 4),
        ("LEFTPADDING",(0,0),(-1,-1), 10),
        ("RIGHTPADDING",(0,0),(-1,-1), 10),
        ("BOX",(0,0),(-1,-1), 0.8, border),
    ]))
    return t

def red_box(title, items):
    return single_box(title, items, bg=RED_SOFT, border=ORANGE)

# ═══════════════════════════════════════════════════════════════════
# DATA
# ═══════════════════════════════════════════════════════════════════

comparison_rows = [
    # ── DEFINITION & BASIC
    ("Definition",
     "Seizure with fever, NO CNS infection, in a neurologically normal child",
     "Recurrent, unprovoked seizures (≥2 seizures, NOT provoked by fever or acute illness)"),

    ("Age of onset",
     "6 months – 5 years (peak: 9–20 months)",
     "Any age; most childhood epilepsies start in first decade"),

    ("Relation to fever",
     "ALWAYS associated with fever (>38°C / 100.4°F); occurs on RISING phase of fever",
     "NOT related to fever; seizures occur without fever"),

    ("Seizure type",
     "Usually generalised tonic-clonic (symmetric)",
     "Variable: generalised, focal, myoclonic, absence — depends on syndrome"),

    ("Duration",
     "Simple: <15 min  •  Complex: >15 min (febrile status)",
     "Usually <2–3 min; status epilepticus possible but uncommon"),

    ("Recurrence in same illness",
     "Simple: does NOT recur within 24 h  •  Complex: recurs within 24 h",
     "Seizures recur WITHOUT fever; triggered by stress, sleep deprivation, lights"),

    ("Focal features",
     "Simple: ABSENT  •  Complex: focal features present (Todd's paresis possible)",
     "Common in focal epilepsy syndromes (temporal, frontal lobe)"),

    ("Post-ictal state",
     "Brief, returns to baseline quickly",
     "Prolonged post-ictal confusion, drowsiness or focal deficit may occur"),

    ("Neurological baseline",
     "Neurologically NORMAL between episodes",
     "May have underlying neurological abnormality or developmental delay"),

    ("EEG",
     "NORMAL inter-ictally; NOT routinely indicated after simple febrile seizure",
     "Abnormal inter-ictal EEG often present; essential for diagnosis and classification"),

    ("Neuroimaging (CT/MRI)",
     "NOT routinely indicated after first simple febrile seizure",
     "Indicated if focal deficit, partial seizure, or atypical features"),

    ("CSF / Lumbar puncture",
     "Indicated if signs of meningism; routine LP NOT needed for simple FS",
     "Not a routine investigation; done only to rule out meningitis in first febrile episode"),

    ("Recurrence risk",
     "30–50% chance of ≥1 further febrile seizure; resolves by age 5",
     "High recurrence risk without AEDs; persists beyond childhood in many syndromes"),

    ("Risk of developing epilepsy",
     "Simple FS: ~2% (same as general population)  •  Complex FS: 6–49% (one, two, or three complex features respectively)",
     "By definition, the child already has epilepsy; risk of ongoing seizures depends on syndrome"),

    ("Family history",
     "Family history of febrile seizures common (polygenic inheritance); positive in 25%",
     "Family history of epilepsy; specific genetics in Dravet, JME, etc."),

    ("Treatment – acute",
     "Diazepam (IV/rectal) if seizure >5 min; simple FS needs no AED",
     "Benzodiazepine for acute seizure; AEDs for long-term control"),

    ("Long-term AED prophylaxis",
     "NOT indicated; does NOT prevent later epilepsy; rectal/oral diazepam at fever onset if high-risk",
     "Indicated (valproate, carbamazepine, lamotrigine, ethosuximide etc. per syndrome)"),

    ("Prognosis / outcome",
     "Excellent; 98% seizure-free by age 5; normal school progress; no cognitive impact",
     "Variable; depends on syndrome — benign (BECTS) to refractory (Lennox-Gastaut)"),

    ("EEG post-ictal",
     "Normal inter-ictal EEG",
     "Abnormal: spike-wave, hypsarrhythmia, focal spikes etc."),
]

risk_complex_items = [
    "Prolonged duration (>15 min)",
    "Focal features (asymmetric seizure, Todd's paresis)",
    "Recurrence within 24 h in same febrile illness",
    "Note: These three complex features = risk 6%, 17%, 49% for later epilepsy respectively",
]

risk_epilepsy_items = [
    "Pre-existing neurodevelopmental abnormality / cerebral palsy",
    "Complex febrile seizure features (all 3 features = 49% risk)",
    "Family history of epilepsy (NOT just febrile seizures)",
    "Multiple recurrent febrile seizures",
    "Dravet syndrome presentation (prolonged, asymmetric FS in first year)",
]

simple_vs_complex = [
    ("Feature", "Simple Febrile Seizure", "Complex Febrile Seizure"),
    ("Duration", "<15 minutes", ">15 minutes"),
    ("Type", "Generalised (tonic-clonic)", "May be FOCAL"),
    ("Recurrence (24 h)", "Single event in 24 h", "Recurs within 24 h"),
    ("Post-ictal", "Rapidly returns to normal", "May have Todd's paresis"),
    ("EEG", "Not indicated", "May be indicated"),
    ("Risk of epilepsy", "~2% (= general population)", "6–49% depending on features"),
    ("LP", "Only if meningism signs", "Strongly consider LP"),
    ("Management", "Reassurance + fever control", "Investigate; consider AED if high-risk"),
]

def simple_vs_complex_table():
    col_w = [4.2*cm, 6.2*cm, 6.2*cm]  # narrowed slightly
    header = [
        Paragraph("Feature", col_head),
        Paragraph("Simple Febrile Seizure", col_head),
        Paragraph("Complex Febrile Seizure", col_head),
    ]
    table_data = [header]
    for i, (feat, simple, cplx) in enumerate(simple_vs_complex[1:]):
        shade = (i % 2 == 0)
        bg = GREY_LIGHT if shade else WHITE
        table_data.append([
            Paragraph(feat, row_label),
            Paragraph(simple, cell_style),
            Paragraph(cplx, cell_style),
        ])
    t = Table(table_data, colWidths=col_w, repeatRows=1)
    t.setStyle(TableStyle([
        ("BACKGROUND",    (0,0),(-1,0), colors.HexColor("#2e6da4")),
        ("TEXTCOLOR",     (0,0),(-1,0), WHITE),
        ("FONTNAME",      (0,0),(-1,0), "Helvetica-Bold"),
        ("ALIGN",         (0,0),(-1,0), "CENTER"),
        ("VALIGN",        (0,0),(-1,-1), "TOP"),
        ("GRID",          (0,0),(-1,-1), 0.4, colors.HexColor("#b0b0b0")),
        ("LINEBELOW",     (0,0),(-1,0), 1.2, BLUE_DARK),
        ("TOPPADDING",    (0,0),(-1,-1), 5),
        ("BOTTOMPADDING", (0,0),(-1,-1), 5),
        ("LEFTPADDING",   (0,0),(-1,-1), 5),
        ("RIGHTPADDING",  (0,0),(-1,-1), 5),
        ("ROWBACKGROUNDS",(0,1),(-1,-1),[WHITE, GREY_LIGHT]),
    ]))
    return t

high_yield_mnemonics = [
    ('SIMPLE febrile seizure: "GANG"',
     "G – Generalised  •  A – Age 6 months–5 yrs  •  N – No recurrence in 24 h  •  G – Gone in <15 min"),
    ('COMPLEX febrile seizure: "FAR"',
     "F – Focal  •  A – Again within 24 h  •  R – Range extended (>15 min)"),
    ("Risk of epilepsy after FS",
     "1 complex feature = 6%   |   2 features = 17%   |   3 features = 49%"),
    ("Epilepsy vs Febrile Seizure",
     "Epilepsy = seizures WITHOUT fever, UNPROVOKED, RECURRENT"),
    ("LP rule",
     "LP NOT routine in simple FS. Perform if: meningism present / age <6 months / incomplete immunisation / pre-treated with antibiotics"),
    ("AED prophylaxis",
     "NOT given for febrile seizures. Given only in epilepsy."),
]

def mnemonic_table():
    data = [[Paragraph(title, cell_bold), Paragraph(body, cell_style)]
            for title, body in high_yield_mnemonics]
    t = Table(data, colWidths=[5.0*cm, 12.0*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND",    (0,0),(-1,-1), AMBER_LIGHT),
        ("GRID",          (0,0),(-1,-1), 0.4, colors.HexColor("#d0c080")),
        ("VALIGN",        (0,0),(-1,-1), "TOP"),
        ("TOPPADDING",    (0,0),(-1,-1), 5),
        ("BOTTOMPADDING", (0,0),(-1,-1), 5),
        ("LEFTPADDING",   (0,0),(-1,-1), 6),
        ("RIGHTPADDING",  (0,0),(-1,-1), 6),
        ("ROWBACKGROUNDS",(0,0),(-1,-1),[AMBER_LIGHT, colors.HexColor("#fffde7")]),
    ]))
    return t

# ═══════════════════════════════════════════════════════════════════
# BUILD DOCUMENT
# ═══════════════════════════════════════════════════════════════════
story = []

# Title
story.append(title_block())
story.append(Spacer(1, 0.4*cm))

# ── SECTION 1: Main Comparison ────────────────────────────────────
story.append(KeepTogether([
    sec_bar("1.  MAIN COMPARISON TABLE"),
    Spacer(1, 0.15*cm),
    comparison_table(comparison_rows),
    Spacer(1, 0.1*cm),
]))

story.append(Spacer(1, 0.4*cm))

# ── SECTION 2: Simple vs Complex Febrile Seizure ─────────────────
story.append(sec_bar("2.  SIMPLE vs COMPLEX FEBRILE SEIZURE", color=colors.HexColor("#1a5276")))
story.append(Spacer(1, 0.15*cm))
story.append(simple_vs_complex_table())
story.append(Spacer(1, 0.4*cm))

# ── SECTION 3: Risk Boxes ─────────────────────────────────────────
story.append(sec_bar("3.  KEY RISK FACTORS", color=colors.HexColor("#1a5276")))
story.append(Spacer(1, 0.2*cm))
story.append(two_col_box(
    "Features Defining COMPLEX Febrile Seizure",
    risk_complex_items,
    "Factors Predicting LATER EPILEPSY after FS",
    risk_epilepsy_items,
    left_bg=BLUE_LIGHT,
    right_bg=AMBER_LIGHT,
))
story.append(Spacer(1, 0.4*cm))

# ── SECTION 4: High-Yield Points / Mnemonics ─────────────────────
story.append(sec_bar("4.  HIGH-YIELD EXAM POINTS  &  MNEMONICS", color=colors.HexColor("#6e2fa8")))
story.append(Spacer(1, 0.15*cm))
story.append(mnemonic_table())
story.append(Spacer(1, 0.3*cm))

# ── SECTION 5: Must-Know One-Liners ──────────────────────────────
story.append(sec_bar("5.  MUST-KNOW ONE-LINERS FOR MCQs", color=ORANGE))
story.append(Spacer(1, 0.15*cm))
oneliners = [
    "Most common age for febrile seizure: 9–20 months (peak); range 6 months–5 years.",
    "Most common type of febrile seizure: Simple generalised tonic-clonic.",
    "EEG after a SIMPLE febrile seizure: NOT routinely indicated.",
    "LP after febrile seizure: Only if signs of meningism; NOT routine.",
    "Antipyretics (paracetamol) do NOT prevent recurrence of febrile seizures.",
    "Drug of choice for ACUTE prolonged febrile seizure / status: IV/rectal Diazepam.",
    "Prophylactic AED for febrile seizures: NOT recommended routinely.",
    "Risk of epilepsy after simple FS: ~2% (barely above 0.5–1% in general population).",
    "Risk of epilepsy with all 3 complex features: ~49% — IMPORTANT MCQ number.",
    "98% of children with febrile seizures are seizure-free by age 5 years.",
    "Dravet syndrome (SCNIA mutation): starts as prolonged febrile seizures in first year of life; progresses to refractory epilepsy.",
    "GEFS+ (Generalised Epilepsy with Febrile Seizures Plus): febrile seizures + afebrile generalised seizures; autosomal dominant.",
    "Febrile status epilepticus: associated with hippocampal injury and later temporal lobe epilepsy (mesial temporal sclerosis).",
    "First-line AED for childhood absence epilepsy: Ethosuximide.",
    "Most common childhood epilepsy with good prognosis: BECTS (Benign Childhood Epilepsy with Centro-Temporal Spikes); remits by puberty.",
]
story.append(single_box("", oneliners, bg=RED_SOFT, border=ORANGE))
story.append(Spacer(1, 0.4*cm))

# ── SECTION 6: Investigations Summary ────────────────────────────
story.append(sec_bar("6.  INVESTIGATIONS SUMMARY", color=colors.HexColor("#145a32")))
story.append(Spacer(1, 0.15*cm))

inv_data = [
    [Paragraph("Investigation", col_head),
     Paragraph("Febrile Seizure (Simple)", col_head),
     Paragraph("Febrile Seizure (Complex)", col_head),
     Paragraph("Epilepsy", col_head)],
    [Paragraph("EEG", row_label),
     Paragraph("NOT routinely indicated", cell_style),
     Paragraph("May be indicated", cell_style),
     Paragraph("Essential; often diagnostic", cell_style)],
    [Paragraph("MRI Brain", row_label),
     Paragraph("NOT indicated", cell_style),
     Paragraph("Consider if focal", cell_style),
     Paragraph("Indicated (focal, structural epilepsy)", cell_style)],
    [Paragraph("Lumbar Puncture", row_label),
     Paragraph("Only if meningism; age <6 m; incomplete immunisation", cell_style),
     Paragraph("Strongly consider", cell_style),
     Paragraph("If first episode with fever to exclude meningitis", cell_style)],
    [Paragraph("Blood tests", row_label),
     Paragraph("Only for fever source; not the seizure", cell_style),
     Paragraph("Glucose, electrolytes, cultures", cell_style),
     Paragraph("Targeted (metabolic screen in new-onset)", cell_style)],
    [Paragraph("Genetic testing", row_label),
     Paragraph("Not routine", cell_style),
     Paragraph("If Dravet suspected (SCN1A)", cell_style),
     Paragraph("When syndrome suggests (SCNIA, KCNQ2, etc.)", cell_style)],
]
inv_t = Table(inv_data, colWidths=[3.5*cm, 4.3*cm, 4.3*cm, 4.3*cm], repeatRows=1)
inv_t.setStyle(TableStyle([
    ("BACKGROUND",    (0,0),(-1,0), colors.HexColor("#145a32")),
    ("TEXTCOLOR",     (0,0),(-1,0), WHITE),
    ("FONTNAME",      (0,0),(-1,0), "Helvetica-Bold"),
    ("ALIGN",         (0,0),(-1,0), "CENTER"),
    ("VALIGN",        (0,0),(-1,-1), "TOP"),
    ("GRID",          (0,0),(-1,-1), 0.4, colors.HexColor("#b0c0b0")),
    ("LINEBELOW",     (0,0),(-1,0), 1.2, colors.HexColor("#0b3d22")),
    ("TOPPADDING",    (0,0),(-1,-1), 5),
    ("BOTTOMPADDING", (0,0),(-1,-1), 5),
    ("LEFTPADDING",   (0,0),(-1,-1), 5),
    ("RIGHTPADDING",  (0,0),(-1,-1), 5),
    ("ROWBACKGROUNDS",(0,1),(-1,-1), [WHITE, colors.HexColor("#e8f5e9")]),
]))
story.append(inv_t)
story.append(Spacer(1, 0.5*cm))

# ── Footer ────────────────────────────────────────────────────────
story.append(HRFlowable(width="100%", thickness=0.5, color=BLUE_MID))
story.append(Spacer(1, 0.1*cm))
story.append(Paragraph(
    "Sources: Harrison's Principles of Internal Medicine 22e (2025) • Adams & Victor's Principles of Neurology 12e • "
    "Bradley & Daroff's Neurology in Clinical Practice • Rosen's Emergency Medicine • Tintinalli's Emergency Medicine • "
    "Swanson's Family Medicine Review  |  For MBBS Final Year Examinations",
    footer_style))

# ── Build ─────────────────────────────────────────────────────────
doc.build(story)
print("PDF created:", OUTPUT)

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm
from reportlab.lib.styles import ParagraphStyle
from reportlab.platypus import SimpleDocTemplate, Table, TableStyle, Paragraph, Spacer, HRFlowable
from reportlab.lib.enums import TA_CENTER, TA_LEFT

OUTPUT = "/tmp/workspace/febrile-seizure-pdf/Febrile_Seizure_vs_Epilepsy_EXAM.pdf"

doc = SimpleDocTemplate(
    OUTPUT, pagesize=A4,
    rightMargin=1.5*cm, leftMargin=1.5*cm,
    topMargin=1.5*cm, bottomMargin=1.5*cm
)

# ── Colours ──────────────────────────────────────────────────────
NAVY       = colors.HexColor("#0d2b4e")
BLUE_HDR   = colors.HexColor("#1a5276")
BLUE_SUB   = colors.HexColor("#2980b9")
ROW_SHADE  = colors.HexColor("#eaf2fb")
WHITE      = colors.white
TEXT       = colors.HexColor("#111111")
GOLD       = colors.HexColor("#d4ac0d")
LIGHT_GOLD = colors.HexColor("#fef9e7")

# ── Styles ────────────────────────────────────────────────────────
title_s = ParagraphStyle("T", fontName="Helvetica-Bold",
    fontSize=16, textColor=WHITE, alignment=TA_CENTER, leading=20)
sub_s = ParagraphStyle("S", fontName="Helvetica",
    fontSize=8.5, textColor=colors.HexColor("#aed6f1"),
    alignment=TA_CENTER, leading=11)
hdr_s = ParagraphStyle("H", fontName="Helvetica-Bold",
    fontSize=9.5, textColor=WHITE, alignment=TA_CENTER, leading=12)
feat_s = ParagraphStyle("F", fontName="Helvetica-Bold",
    fontSize=8.5, textColor=NAVY, alignment=TA_LEFT, leading=11)
cell_s = ParagraphStyle("C", fontName="Helvetica",
    fontSize=8.5, textColor=TEXT, alignment=TA_LEFT, leading=11)
foot_s = ParagraphStyle("FT", fontName="Helvetica-Oblique",
    fontSize=7, textColor=colors.HexColor("#777777"), alignment=TA_CENTER)

# ── Data: (Feature, Febrile Seizure, Epilepsy) ───────────────────
ROWS = [
    ("Definition",
     "Seizure WITH fever, NO CNS infection, in a neurologically NORMAL child",
     "≥2 unprovoked (afebrile) recurrent seizures NOT triggered by fever"),

    ("Age of onset",
     "6 months – 5 years  (peak 9–20 months)",
     "Any age; most childhood syndromes in first decade"),

    ("Relation to fever",
     "ALWAYS with fever >38°C; occurs on RISING phase of temperature",
     "NO fever relationship; occurs spontaneously"),

    ("Seizure type",
     "Generalised tonic-clonic (symmetric) — SIMPLE type\nFocal features only in COMPLEX type",
     "Variable: generalised, focal, absence, myoclonic — depends on syndrome"),

    ("Duration",
     "Simple: <15 min\nComplex (febrile status): >15 min",
     "Usually <2–3 min per episode; status epilepticus possible"),

    ("Recurrence in\nsame illness",
     "Simple: does NOT recur within 24 h\nComplex: recurs within 24 h / same febrile illness",
     "Recurs WITHOUT fever; triggered by sleep deprivation, stress, lights"),

    ("Focal features",
     "Simple: ABSENT\nComplex: focal (Todd's paresis may follow)",
     "Common in focal epilepsy (temporal / frontal lobe syndromes)"),

    ("Post-ictal phase",
     "Brief; child returns to baseline QUICKLY",
     "Prolonged confusion, drowsiness, or focal deficit may persist"),

    ("Neuro status\nbetween episodes",
     "NORMAL — no neurological deficit",
     "May have underlying neurological abnormality / developmental delay"),

    ("EEG",
     "NORMAL inter-ictally\nNOT routinely indicated after simple FS",
     "Abnormal inter-ictal EEG — ESSENTIAL for diagnosis & classification"),

    ("MRI / CT Brain",
     "NOT routinely indicated after first simple FS",
     "Indicated when focal seizure, structural cause, or atypical features"),

    ("Lumbar puncture",
     "Only if signs of MENINGISM\nConsider: age <6 m / incomplete immunisation / pre-treated antibiotics",
     "Not a routine test; only to exclude meningitis in first febrile episode"),

    ("Risk of future\nepilepsy",
     "Simple FS: ~2% (≈ general population risk)\nComplex FS: 6% (1 feature) / 17% (2 features) / 49% (3 features)",
     "Already diagnosed as epilepsy; ongoing risk depends on syndrome"),

    ("Recurrence risk",
     "30–50% chance of ≥1 further febrile seizure; resolves by age 5",
     "High without AED; seizures persist in most syndromes"),

    ("Family history",
     "Family history of FEBRILE seizures (polygenic); positive ~25%",
     "Family history of EPILEPSY; specific gene mutations in some syndromes"),

    ("Acute treatment",
     "Diazepam IV/rectal if seizure >5 min\nSimple FS: NO antiepileptic needed",
     "Benzodiazepine acutely; AED started for long-term control"),

    ("Long-term AED\nprophylaxis",
     "NOT indicated — does NOT prevent later epilepsy\nRectal/oral diazepam at fever onset only in selected high-risk cases",
     "INDICATED — valproate, carbamazepine, lamotrigine, ethosuximide etc."),

    ("Antipyretics",
     "Do NOT prevent recurrence of febrile seizures",
     "Not relevant"),

    ("Prognosis",
     "EXCELLENT — 98% seizure-free by age 5; normal development & schooling",
     "Variable: benign (BECTS remits by puberty) → refractory (Lennox-Gastaut)"),

    ("Key associated\nsyndromes",
     "Dravet syndrome starts as prolonged FS in infancy (SCN1A mutation)\nGEFS+ — febrile + afebrile seizures; autosomal dominant",
     "Absence epilepsy, JME, BECTS, West syndrome, Lennox-Gastaut etc."),
]

# ── Title block ───────────────────────────────────────────────────
title_tbl = Table([
    [Paragraph("Febrile Seizure  vs  Epilepsy in Paediatrics", title_s)],
    [Paragraph("MBBS Final Year  |  Exam-Focused Comparison  |  Harrison's 22e · Adams & Victor 12e · Bradley & Daroff's Neurology", sub_s)],
], colWidths=[18.0*cm])
title_tbl.setStyle(TableStyle([
    ("BACKGROUND",    (0,0),(-1,-1), NAVY),
    ("TOPPADDING",    (0,0),(-1,-1), 8),
    ("BOTTOMPADDING", (0,0),(-1,-1), 7),
    ("LEFTPADDING",   (0,0),(-1,-1), 10),
    ("RIGHTPADDING",  (0,0),(-1,-1), 10),
]))

# ── Main table ────────────────────────────────────────────────────
COL_W = [3.8*cm, 7.1*cm, 7.1*cm]

header_row = [
    Paragraph("Feature", hdr_s),
    Paragraph("Febrile Seizure", hdr_s),
    Paragraph("Epilepsy (Childhood)", hdr_s),
]

table_data = [header_row]
for i, (feat, feb, epi) in enumerate(ROWS):
    table_data.append([
        Paragraph(feat, feat_s),
        Paragraph(feb, cell_s),
        Paragraph(epi, cell_s),
    ])

main_tbl = Table(table_data, colWidths=COL_W, repeatRows=1)
main_tbl.setStyle(TableStyle([
    # Header row
    ("BACKGROUND",    (0,0), (-1,0), BLUE_HDR),
    ("LINEBELOW",     (0,0), (-1,0), 1.5, NAVY),
    # Alternating rows
    ("ROWBACKGROUNDS",(0,1), (-1,-1), [WHITE, ROW_SHADE]),
    # Grid
    ("GRID",          (0,0), (-1,-1), 0.35, colors.HexColor("#aab7c4")),
    ("LINEAFTER",     (0,0), (0,-1), 0.8, BLUE_SUB),
    # Alignment & padding
    ("VALIGN",        (0,0), (-1,-1), "TOP"),
    ("ALIGN",         (0,0), (-1,0), "CENTER"),
    ("TOPPADDING",    (0,0), (-1,-1), 5),
    ("BOTTOMPADDING", (0,0), (-1,-1), 5),
    ("LEFTPADDING",   (0,0), (-1,-1), 5),
    ("RIGHTPADDING",  (0,0), (-1,-1), 5),
    # Feature column slightly bolder bg
    ("BACKGROUND",    (0,1), (0,-1), colors.HexColor("#d6eaf8")),
]))

# ── Footer ────────────────────────────────────────────────────────
footer = Paragraph(
    "Sources: Harrison's Principles of Internal Medicine 22e (2025)  •  Adams & Victor's Principles of Neurology 12e  •  "
    "Bradley & Daroff's Neurology in Clinical Practice  •  Rosen's Emergency Medicine  |  MBBS Final Year Paediatrics",
    foot_s)

# ── Build ─────────────────────────────────────────────────────────
story = [
    title_tbl,
    Spacer(1, 0.35*cm),
    main_tbl,
    Spacer(1, 0.25*cm),
    HRFlowable(width="100%", thickness=0.5, color=BLUE_SUB),
    Spacer(1, 0.08*cm),
    footer,
]

doc.build(story)
print("Done:", OUTPUT)