For short-term relief until urgent dental treatment, use a non-opioid option if the patient is an adult and has no contraindications:
- Ibuprofen 400 mg by mouth every 6 hours as needed, with food.
Maximum: 1,200 mg/day without clinician supervision.
- For severe pain, ibuprofen 400 mg plus acetaminophen/paracetamol 500 mg together every 6 hours as needed can work better than either alone.
Keep total acetaminophen from all products to 3,000 mg/day maximum (lower limit if liver disease or regular alcohol use).
The
ADA acute dental-pain guidance recommends NSAIDs such as ibuprofen, alone or combined with acetaminophen, as first-line temporary treatment for toothache.
Do not use ibuprofen/NSAIDs if there is a history of stomach ulcer or GI bleeding, significant kidney disease, NSAID allergy/asthma reaction, use of blood thinners, or pregnancy. In those situations, acetaminophen alone may be safer, but a clinician should advise. Avoid combining ibuprofen with naproxen, diclofenac, or aspirin used for pain. Avoid alcohol with acetaminophen.
Antibiotics do not usually relieve pain from an inflamed wisdom tooth without signs of spreading infection and should not be self-started. The tooth needs prompt dental assessment, often within 24 hours, for definitive treatment.
Seek emergency care now for facial/neck swelling, fever, pus, difficulty swallowing or breathing, inability to open the mouth, confusion, or rapidly worsening pain.