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Nutritional Anaemia
(Park's Textbook of Preventive and Social Medicine)
Definition
Nutritional anaemia is a disease syndrome caused by malnutrition in its widest sense. WHO defines it as: "A condition in which the haemoglobin content of blood is lower than normal as a result of a deficiency of one or more essential nutrients, regardless of the cause of such deficiency."
By far the most frequent cause is iron deficiency; folate and vitamin B12 deficiency are less frequent causes.
Diagnostic Cut-off Points (WHO) - Table 12
| Group | Haemoglobin (g/dl) | MCHC (%) |
|---|
| Adult males | 13 | 34 |
| Adult females (non-pregnant) | 12 | 34 |
| Adult females (pregnant) | 11 | 34 |
| Children 6 months - 6 years | 11 | 34 |
| Children 6 - 14 years | 12 | 34 |
- Hb 10-11 g/dl = Early anaemia
- Hb < 10 g/dl = Marked anaemia
The Problem
Global
Nutritional anaemia is a worldwide problem with the highest prevalence in developing countries. It particularly affects:
- Women of child-bearing age
- Young children
- Pregnant and lactating women
- It is estimated to affect nearly two-thirds of pregnant and one-half of non-pregnant women in developing countries.
India
Iron deficiency anaemia is the most widespread micronutrient deficiency in India, affecting all age groups irrespective of gender, caste, creed, and religion.
- 72.7% of children up to 3 years in urban areas are anaemic; 81.2% in rural areas.
- Bihar had the highest prevalence (87.6%), while Nagaland had the lowest (44.3%).
- 72.6% of adolescent girls in India are anaemic.
- Iron deficiency anaemia is described as a "silent emergency" in India.
Causes / Aetiology
Iron balance depends on the interplay between:
- Inadequate dietary intake - Diets largely composed of cereals and pulses with low bioavailability of iron (especially phytate-rich foods).
- Poor bioavailability - Plant (non-haem) iron has poor absorption. This is considered a major reason for widespread iron deficiency in India.
- Increased physiological demands - Pregnancy, lactation, infancy, adolescence.
- Blood/iron losses -
- Physiological: menstruation, childbirth
- Pathological: hookworm infestation, malaria, haemorrhoids, peptic ulcer
- Use of IUDs increases average monthly blood loss by 35-146%
- Frequent pregnancies at close intervals - Additional demands from rapid pregnancies and blood loss during delivery.
- Folate / Vitamin B12 deficiency - Causes megaloblastic anaemia; sub-clinical folate deficiency found in ~30% of pregnant women in rural North India.
Three Stages of Iron Deficiency
(a) First stage: Decreased iron stores without any other detectable abnormality.
(b) Second stage - Latent Iron Deficiency: Iron stores exhausted but anaemia has not yet occurred. Serum ferritin falls; transferrin saturation drops from normal 30% to < 15%. This is the most widely prevalent stage in India.
(c) Third stage - Overt Iron Deficiency Anaemia: Decrease in circulating haemoglobin due to impaired haemoglobin synthesis.
Evaluation of Iron Status
| Parameter | Normal | Deficiency |
|---|
| Haemoglobin | See Table 12 | Below cut-off values |
| Serum iron | 0.80-1.80 mg/L | < 0.50 mg/L |
| Serum ferritin (most sensitive) | > 10 mcg/L | < 10 mcg/L (absent stores) |
| Serum transferrin saturation | > 30% | < 16% |
Detrimental Effects
(a) Pregnancy: Anaemia increases risk of maternal and foetal mortality and morbidity. In India, 19% of maternal deaths are due to anaemia. Associated with: abortions, premature births, postpartum haemorrhage, low birth weight.
(b) Infection: Anaemia can be caused/aggravated by malaria and intestinal parasites. Iron deficiency also impairs cell-mediated immunity and increases susceptibility to infection.
(c) Work capacity: Even mild anaemia causes significant impairment of maximal work capacity, reducing productivity with major economic consequences.
Interventions / Control
1. Iron and Folic Acid Supplementation
The Government of India launched the National Nutritional Anaemia Prophylaxis Programme (Fourth Five Year Plan) targeting "at-risk" groups: pregnant women, lactating mothers, and children under 12 years.
Eligibility: Hb 10-12 g/dl = supplementation; Hb < 10 g/dl = refer to PHC.
Dosage:
- Mothers: 1 tablet daily containing 100 mg elemental iron (300 mg ferrous sulphate) + 0.5 mg folic acid. Continue 2-3 months after Hb normalizes.
- Children (< 5 years): 1 tablet = 20 mg elemental iron (60 mg ferrous sulphate) + 0.1 mg folic acid daily for 100 days. Liquid formulation for ages 6-60 months.
- Children 6-10 years: 30 mg elemental iron + 250 mcg folic acid/day for 100 days.
- Adolescents: Same dosage and duration as adults.
2. Iron Fortification
Studies at the National Institute of Nutrition, Hyderabad showed that ferric ortho-phosphate or ferrous sulphate with sodium bisulphate added to common salt effectively fortified it with iron. Consumption over 12-18 months reduced the prevalence of anaemia.
3. Dietary Diversification
Promoting consumption of iron-rich foods:
- Dark green leafy vegetables, animal foods, organ meats
- Foods enhancing iron absorption: vitamin C (ascorbic acid)
- Avoiding inhibitors of iron absorption with meals (e.g., tea, phytates)
4. Treatment of Underlying Causes
- Deworming for hookworm infestation
- Treatment of malaria
- Family planning to space pregnancies
- Hormonal contraceptives reduce menstrual blood loss by ~50%
5. Anaemia Mukt Bharat Programme
A national initiative under the government aimed at reducing the burden of anaemia across all life stages through a multi-pronged strategy covering supplementation, deworming, dietary diversification, and behaviour change communication.
Summary (for quick recall)
| Aspect | Key Points |
|---|
| Definition | Low Hb due to nutrient deficiency (WHO) |
| Commonest cause | Iron deficiency |
| Most at risk | Pregnant women, children, adolescent girls |
| Most sensitive test | Serum ferritin |
| Most prevalent stage in India | Latent iron deficiency |
| Maternal mortality | 19% of maternal deaths in India |
| Key programme | NNAAP / Anaemia Mukt Bharat |
Source: Park's Textbook of Preventive and Social Medicine, Chapter on Nutrition and Health