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Sepsis
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What specific aspect of sepsis are you interested in? For example:
- A particular mechanism (coagulation, cytokine storm, etc.)
- Pediatric or neonatal sepsis
- A specific organism or source (e.g. gram-negative, urinary source)
- Biomarkers (lactate, procalcitonin, etc.)
- Something else entirely
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"sepsis" AND "surviving sepsis campaign" AND "bundle"
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Here are the first 2 flashcards generated. Cards 3-5 were declined - no problem, I'll present all 5 as text-based flashcards below with the full content from the textbooks.
Sepsis: Management & Treatment Bundles — 5 Flashcards
Card 1
Card 2
Card 3 — Sepsis Bundle Timeframe
Q: What is the target timeframe for completing the Sepsis Bundle?
- Original goal: 3 hours from presentation
- Current advocacy: 1 hour (faster completion = lower in-hospital mortality)
- Controversy: Not all screen-positive patients have confirmed sepsis - risk of unnecessary antibiotics and overly aggressive fluid resuscitation
Source: Current Surgical Therapy 14e
Card 4 — The Sepsis Six
Q: What are the "Sepsis Six" interventions?
Complete within 1 hour of diagnosis:
- Administer high-flow oxygen
- Take blood cultures
- Give broad-spectrum antibiotics
- Give IV fluid challenges
- Measure serum lactate
- Measure hourly urine output
Designed to make early management reliably achievable by junior staff, with senior/critical care escalation when needed.Source: Scott-Brown's Otorhinolaryngology & Head and Neck Surgery
Card 5 — Vasopressors & Fluid Strategy in Septic Shock
Q: What vasopressor and fluid strategy is used in septic shock?
- Fluids: 30 mL/kg IV crystalloid for initial resuscitation
- Vasopressor: Norepinephrine (noradrenaline) is first-line - target MAP ≥ 65 mmHg
- Start vasopressors if hypotension persists despite adequate fluids
- Early Goal-Directed Therapy (EGDT) is no longer recommended (does not reduce 90-day all-cause mortality)
- ICU bundles improve outcomes when used after initial resuscitation
Source: Creasy & Resnik's Maternal-Fetal Medicine; ESICM Guidelines 2025
Sources: Current Surgical Therapy 14e | Creasy & Resnik's Maternal-Fetal Medicine | Scott-Brown's ENT & Head and Neck Surgery | ESICM Circulatory Shock Guidelines 2025
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