We are still confused folfirinox failed gemcitabin + nab paclitaxel fail what we are lest with option 1 non standard line of approach keytruda + linvatinb option 2 lyposomal orinotcane + s1 and option 3 modify gemcitabin + cisplatin analyse the condition and suggest keep in mind this is not hit and trial method already two line of treatment’s failed And negative to germlime brac not presend