Q: What, what dose does aspirin cause analgesia? A: For analgesia in adults, aspirin is usually given as 325-1000 mg orally every 4-6 hours as needed. - Maximum commonly stated OTC limit: 4 g/day unless specifically directed by a clinician. - Low-dose aspirin 75-100 mg/day, such as 81 mg is mainly antiplatelet therapy, not the usual analgesic dose. - Avoid aspirin in children or teenagers with viral illness because of the risk of Reye syndrome. Goodman & Gilman lists the adult analgesic-antipyretic range as 325-1000 mg every 4-6 hours.