Acute diarrhea with mucus can occur with intestinal infection or inflammation. It needs more attention than simple watery diarrhea, especially if there is fever, blood, cramping, or a frequent urge to pass stool.
Many acute cases are self-limited, but mucus can be a feature of inflammatory diarrhea. Stool testing or targeted treatment may be needed when there is blood, fever, severe illness, persistent symptoms, immunosuppression, or recent antibiotics, consistent with
primary-care guidance on acute diarrhea. Acute diarrhea is generally defined as lasting 14 days or less.
Frameworks for Internal Medicine, “Key Points.”