Tab amoxclav 625mg schedule
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amoxicillin clavulanate 625mg dosage schedule adults
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Here is the complete prescribing schedule for Tab Amoxclav 625 mg (Amoxicillin 500 mg + Clavulanate 125 mg):
Tab Amoxclav 625 mg - Dosage Schedule
Standard Adult Dose
| Severity | Dose | Frequency | Duration |
|---|---|---|---|
| Mild to Moderate | 1 tab (625 mg) | Every 8 hours (TDS) | 5-7 days |
| Severe | Use 875/125 mg tab or higher formulation | Every 12 hours | 7-14 days |
The 625 mg tablet (500 mg amoxicillin + 125 mg clavulanate) is specifically the TID (three times daily / every 8 hours) formulation, per The Harriet Lane Handbook and Murray & Nadel's Respiratory Medicine.
Indication-Specific Schedules
| Indication | Dose & Frequency | Duration |
|---|---|---|
| Upper/Lower RTI (sinusitis, bronchitis, pneumonia) | 625 mg q8h | 5-10 days |
| Otitis media | 625 mg q8h | 5-10 days |
| Skin & soft tissue infections / bite wounds | 625 mg q8h | 5-7 days |
| UTI (uncomplicated) | 625 mg q8h | 3-5 days |
| UTI (complicated) | 625 mg q8h | 7-14 days |
| Dental/orofacial infections | 625 mg q8h | 5-7 days |
| Diabetic foot / deep tissue | 625 mg q8h | Up to 14 days |
Key Administration Points
- Take with food - reduces nausea and GI upset significantly (clavulanate is the GI-irritating component)
- Take at evenly spaced intervals - every 8 hours (e.g., 6 AM, 2 PM, 10 PM)
- Complete the full course even if symptoms improve
- Do not crush or chew the tablet
Dose Adjustments
| Condition | Adjustment |
|---|---|
| CrCl 10-30 mL/min | 625 mg every 12 hours |
| CrCl <10 mL/min | 625 mg every 24 hours |
| Haemodialysis | 625 mg every 24 hours + extra dose during and at end of dialysis |
| Hepatic impairment | Use with caution; monitor liver function |
Contraindications & Cautions
- Avoid if history of penicillin/beta-lactam hypersensitivity
- Avoid if previous cholestatic jaundice or hepatic dysfunction with amoxicillin-clavulanate
- Monitor INR if on warfarin (can prolong prothrombin time)
- Can reduce efficacy of oral contraceptives
Sources: Murray & Nadel's Textbook of Respiratory Medicine; The Harriet Lane Handbook, 23rd ed.; Drugs.com Dosage Guide
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