Here is a complete, practical guide for a 22-day-old baby with white patches in the mouth:
Diagnosis: Oral Thrush (Neonatal Oral Candidiasis)
White patches on the inner cheeks, tongue, gums, or roof of the mouth in a newborn are almost always oral thrush - a fungal (Candida) infection. It is very common in the first few weeks of life because newborns have immature immunity. The baby likely picked up Candida from the birth canal or from the mother's nipples during feeding.
How to tell it's thrush (not milk): Milk residue wipes off easily. Thrush patches are firmly attached and may bleed slightly if you try to wipe them off.
What to Give
First-line treatment: Nystatin oral drops
- Nystatin suspension (100,000 units/mL) - this is the standard treatment for neonatal oral thrush
- Dose: 1 mL (100,000 units) in each side of the mouth, 4 times a day, for 7-14 days
- Apply with a dropper directly onto the white patches inside the mouth after a feed
- Continue for at least 2 days after the patches clear to prevent relapse
As confirmed in Creasy & Resnik's Maternal-Fetal Medicine: "The infant receives nystatin drops orally to the oral mucous membranes after each feeding."
And from Fitzpatrick's Dermatology: "Oral nystatin is indicated if oral thrush is present."
If nystatin fails (recurrent or persistent): Fluconazole
- Fluconazole (oral) may be used if thrush persists beyond 2 weeks or recurs
- Dose in infants: 6 mg/kg on day 1, then 3 mg/kg every 24 hours
- Only use if prescribed by a doctor
Important Steps Alongside Treatment
| Action | Why |
|---|
| Treat the mother's nipples too (with nystatin ointment after each feed) | Baby and mother re-infect each other in a cycle |
| Sterilize pacifiers, bottle nipples, breast pump parts daily | Candida survives on rubber/silicone |
| Discard old pacifiers and replace | Reinfection source |
| Check for diaper rash (candida diaper rash) | Same infection can spread down |
| Continue breastfeeding - do not stop | Thrush is not a reason to stop |
Warning Signs - See a Doctor Immediately If:
- Baby refuses to feed or is feeding very poorly
- White patches spread to the throat or beyond
- Baby has fever
- Patches do not improve after 1 week of nystatin
- You are not sure if it is thrush or something else
Do NOT Do
- Do not forcefully wipe or scrape the patches
- Do not apply gentian violet on a 22-day-old without medical advice (can cause mouth sores)
- Do not use adult antifungal gels without a prescription
Bottom line: Get Nystatin oral drops from a pharmacy (available over the counter in most countries, or with a prescription). Apply after each feeding, 4 times a day, for at least 7-14 days. Treat the mother's nipples at the same time. The baby should improve within a few days, but complete the full course. If there is no improvement in 5-7 days, see a pediatrician.