Surgical Short Cases - Bailey & Love's Short Practice of Surgery (28th Edition)
13. ACHALASIA CARDIA
Definition/Aetiology: Achalasia (Greek "khalasis" = failure to relax) is an oesophageal motility disorder with a prevalence of 1.8-12.6/100,000/year. It results from loss of inhibitory ganglion cells in the myenteric (Auerbach's) plexus, possibly triggered by a virus-induced autoimmune process. Histology shows reduced ganglion cell numbers with variable chronic inflammation. In South America, Trypanosoma cruzi infection (Chagas' disease) destroys the myenteric plexus, producing a clinically identical picture. A rare genetic association is Allgrove syndrome (adrenal insufficiency, alacrimia, achalasia) - Bailey and Love's Short Practice of Surgery, 28th ed.
Pathophysiology: Loss of primary peristalsis and failure of lower oesophageal sphincter (LOS) relaxation causes the oesophagus to empty only by hydrostatic pressure - always incomplete. Progressive dilatation produces "megaoesophagus." Retention oesophagitis from food fermentation predisposes to oesophageal carcinoma.
Clinical features: Peak age 30-60 years. Dysphagia to both solids AND liquids (key distinguishing feature from a stricture), regurgitation, heartburn (often misdiagnosed as GORD), chest pain/odynophagia early on, variable weight loss. Presentation is often insidious with long delay to diagnosis.
Investigations:
- Barium swallow - classic "bird's beak"/"rat's tail" tapering at the OGJ with proximal dilatation
- Upper GI endoscopy - mandatory to exclude pseudoachalasia (malignancy at OGJ mimicking achalasia - important differential, especially in older patients)
- High-resolution manometry (HRM) - gold standard; Chicago classification divides oesophageal motility disorders into disorders of OGJ outflow (elevated integrated relaxation pressure - IRP) including 3 subtypes of achalasia, versus disorders of peristalsis
Management:
- Botulinum toxin - endoscopic injection into LOS; blocks presynaptic acetylcholine release. Symptom relief ~70% at 3 months falling to ~40% at 1 year; repeated injections cause scarring. Reserved for elderly/comorbid patients unsuitable for definitive therapy, or when diagnosis is uncertain.
- Pneumatic dilatation - graded balloon stretching of the LOS.
- Heller's cardiomyotomy (laparoscopic, often with a Dor or Toupet partial fundoplication to prevent reflux) - definitive surgical treatment.
- POEM (peroral endoscopic myotomy) - increasingly used endoscopic alternative to surgical myotomy.
- Medical therapy (nitrates, calcium channel blockers) reserved for patients unfit for endoscopic/surgical treatment.
14. ILEOCAECAL TUBERCULOSIS
Aetiology: Intra-abdominal TB accounts for ~11% of extrapulmonary TB and is common in resource-poor countries, with rising incidence elsewhere due to migration and immunosuppression (HIV co-infection with M. avium intracellulare). The ileocaecal region is the classic site because of abundant lymphoid (Peyer's patch) tissue - Bailey and Love's Short Practice of Surgery, 28th ed.
Pathological types:
- Ulcerative (Ulcerotuberculosis) - secondary to swallowed tubercle bacilli from pulmonary TB; multiple transverse ulcers in the terminal ileum with thickened, reddened, tubercle-studded serosa. Presents with diarrhoea and weight loss; subacute obstruction, local perforation, and fistula formation may occur.
- Hyperplastic - occurs in patients with high host resistance; infection lodges in lymphoid follicles causing chronic inflammatory thickening and luminal narrowing, with early caseating regional lymphadenopathy. Unlike Crohn's disease, abscess/fistula formation is uncommon. Presents with colicky abdominal pain, intermittent diarrhoea (incomplete obstruction with stasis/bacterial overgrowth causing steatorrhoea and anaemia), and a right iliac fossa mass.
- Tuberculous peritonitis - wet ascitic type (90%) vs dry plastic type with matted fibrotic bowel loops causing subacute obstruction.
Clinical features: Evening pyrexia, weight loss, right iliac fossa mass, vague ill-health, subacute intestinal obstruction.
Differential diagnosis: Appendix mass, caecal carcinoma, lymphoma, Crohn's disease, actinomycosis.
Investigations:
- Barium follow-through/small bowel enema - long narrow filling defect in terminal ileum (may mimic Crohn's), failure of filling of distal ileum/caecum/ascending colon
- CT - narrowed segment with proximal dilatation and mesenteric lymphadenopathy
- Ascitic fluid analysis (if peritonitis) - straw-coloured exudate, protein >25-30 g/L, WCC >500/mL with >40% lymphocytes; ascitic adenosine deaminase (ADA) has high sensitivity/specificity
- Laparoscopy with peritoneal biopsy when diagnosis unclear
- Xpert MTB/RIF and interferon-gamma release assay - emerging roles
Management: Antituberculous chemotherapy is curative in most cases if started before obstruction develops. Surgery (ileocaecal resection) is required for established obstruction, perforation, or when Crohn's disease/lymphoma cannot be excluded.
15. ULCERATIVE COLITIS
Definition: Chronic inflammatory bowel disease limited to the mucosa, characteristically continuous, starting in the rectum and extending proximally (unlike the skip lesions and transmural involvement of Crohn's disease).
Clinical features: Bloody diarrhoea, urgency, tenesmus. Disease activity is scored using stool frequency, rectal bleeding, sigmoidoscopic appearance, and global assessment (Table 75.2, Bailey and Love).
Extraintestinal manifestations (Bailey and Love, 28th ed.):
- Arthritis (~15%) - asymmetrical large-joint polyarthropathy
- Sacroiliitis/ankylosing spondylitis (20x more common than general population, HLA-B27 associated)
- Primary sclerosing cholangitis - can progress to cirrhosis; rare associated cholangiocarcinoma (risk unaffected by colectomy)
- Skin - erythema nodosum, pyoderma gangrenosum (both resolve with colitis control)
- Eyes - uveitis, episcleritis
Acute severe (fulminant) colitis: Occurs in ~5% of patients. Toxic dilatation suspected with severe abdominal pain and a plain film colon diameter >6 cm. A falling stool frequency with abdominal distension/pain (not reduced disease activity) suggests impending perforation - a grave complication with 40% mortality. Severe haemorrhage occurs in 1-2%.
Cancer risk: Increases with disease duration - approximately 1% at 10 years, rising further with pancolitis of long duration.
Investigations: Colonoscopy with biopsy (continuous mucosal inflammation, crypt abscesses, pseudopolyps), CT (thickened colonic wall, mesenteric stranding), plain abdominal radiograph for toxic dilatation.
Medical treatment:
- 5-ASA derivatives (topical/systemic) - first line, especially for proctitis and maintenance
- Corticosteroids - topical or systemic, for acute flares
- Immunosuppressives - azathioprine/6-mercaptopurine (check TPMT activity before starting to avoid myelosuppression); ciclosporin (IV, ~80% remission in acute severe colitis but high relapse)
- Biologics - infliximab and adalimumab (anti-TNFα); ustekinumab (anti-IL-12/23) and other newer agents
- Modern approach favours "top-down" therapy targeting clinical AND endoscopic remission, with treatment de-escalated once remission is achieved
Indications for surgery: Fulminant colitis unresponsive to medical therapy; chronic disease with anaemia/frequent stools/urgency/tenesmus; steroid dependency; drug intolerance/side effects; growth retardation in children; dysplasia/carcinoma; associated sclerosing cholangitis or severe extraintestinal manifestations; severe haemorrhage or obstructing stricture. Lifetime colectomy risk is ~20%.
Operative treatment:
- Emergency: Subtotal colectomy + end-ileostomy (safest option), with the rectosigmoid remnant managed as a mucous fistula or closed subcutaneously/transanal catheter decompression. Restorative surgery deferred until the patient recovers and is off steroids.
- Elective/restorative: Proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the standard restorative procedure, giving good functional outcome while removing all disease and cancer risk.
16. RECTAL PROLAPSE
Classification (Bailey and Love, Summary Box 79.5):
- May be mucosal or full-thickness
- If full-thickness, the entire rectal wall is involved
- May begin as an internal rectal prolapse (rectal intussusception)
- In children - usually mucosal, treated conservatively
- In adults - often full-thickness, associated with constipation and incontinence; surgery is almost always required
Mucosal prolapse:
- Children: follows diarrhoea or weight loss (loss of ischiorectal fat); associated with cystic fibrosis, neurological disease, Hirschsprung's disease, rectal polyps, pelvic maldevelopment
- Adults: often associated with third-degree haemorrhoids ("mucohaemorrhoidal prolapse"); perineal damage at childbirth in women, urethral obstruction/straining in men, and general pelvic floor weakness in old age
- Treatment: digital repositioning in infants; submucosal phenol-in-almond-oil injection or rubber band ligation; in adults, excision of redundant mucosa, endoluminal stapling, or internal Delorme's procedure for circumferential prolapse
Full-thickness prolapse (procidentia): Less common; involves all layers, usually 4->10-15 cm long, associated with weak pelvic floor/chronic straining. Begins as an intussusception protruding through a patulous, gaping anal sphincter. Prolapse >5 cm contains a peritoneal pouch anteriorly (may contain small bowel or bladder). Women affected 6x more than men; ~50% of adults have coexisting faecal incontinence. Complications: ulceration, bleeding, incarceration/strangulation.
Surgical treatment:
- Perineal approach: Altemeier's procedure (perineal rectosigmoidectomy), Delorme's procedure - preferred in frail/elderly patients due to lower morbidity
- Abdominal approach: rectopexy (e.g. Ripstein/Wells, or laparoscopic ventral mesh rectopexy - LVMR) - lower recurrence rates, preferred in fitter patients
Internal rectal prolapse/solitary rectal ulcer syndrome (SRUS): Rectal intussusception causing obstructed defecation (incomplete evacuation, excessive straining, digitation, tenesmus). SRUS classically produces an anterior rectal ulcer 6-8 cm from the anal verge, which may mimic carcinoma or IBD; biofeedback, STARR procedure (stapled transanal resection), or abdominal rectopexy may be used, though results are less predictable than for external prolapse.
17. FISTULA IN ANO
Definition/Aetiology: A chronic abnormal communication between the anorectal lumen (internal opening) and the perineal/buttock skin (or rarely the vagina). Most are idiopathic/cryptoglandular, arising from infection of the intersphincteric anal glands, lined by granulation tissue. Also seen with Crohn's disease, tuberculosis, lymphogranuloma venereum, actinomycosis, rectal duplication, foreign body, and rarely malignancy - Bailey and Love, 28th ed.
Presentation: Intermittent purulent (sometimes bloody) discharge and discomfort relieved temporarily when pus discharges; often a preceding history of perianal abscess. Passage of flatus/faeces through the opening suggests a rectal (rather than anal) internal opening.
Classification (Park's classification) - based on relation of the primary track to the external sphincter:
- Intersphincteric (45%) - does not cross the external sphincter
- Trans-sphincteric (40%) - crosses both internal and external sphincters into the ischiorectal fossa; may have secondary tracks, including horseshoe spread
- Suprasphincteric (10%) - passes above puborectalis before curling down through the levators; often caused by excessive probing
- Extrasphincteric - passes outside the sphincter complex entirely, usually from pelvic disease
The American Gastroenterological Association classification simplifies this into simple (low, single external opening) versus complex (high, extra/suprasphincteric, associated abscess, ano-vaginal fistula, or stricture) fistula - useful for deciding whether to operate, investigate further, or refer.
Investigations: Endoanal ultrasound (EAUS, with hydrogen peroxide instillation) for sphincter integrity and simple vs complex classification; MRI is the gold standard, especially STIR sequencing for secondary extensions; fistulography/CT if extrasphincteric fistula suspected.
Principles of surgery: Preserve continence while eradicating the fistula.
- Fistulotomy - division of all tissue between internal and external openings over a probe; used for intersphincteric and low trans-sphincteric tracks (<30% external sphincter involvement, not anterior fistulae in women); secondary tracks laid open, wound may be marsupialised. Staged fistulotomy with a loose seton used for higher tracks.
- Fistulectomy - coring out of the tract with diathermy, better anatomical definition than fistulotomy.
- Seton - draining (loose) seton for sepsis control, or cutting seton for gradual division of sphincter muscle.
- Sphincter-preserving techniques - LIFT (ligation of intersphincteric fistula tract), advancement flaps, fistula plug, and FiLaC (laser closure) - reserved for straight trans-sphincteric tracts to avoid continence risk.
18. HYDRONEPHROSIS
Definition: Dilatation of the renal pelvis and calyces resulting from obstruction to the outflow of urine, with progressive renal parenchymal atrophy if unrelieved.
Causes (Bailey and Love, urology chapters):
- Congenital pelviureteric junction (PUJ)/ureteropelvic junction obstruction - aperistaltic segment due to muscular hypoplasia, or an aberrant crossing vessel
- Ureterovesical junction (UVJ) obstruction/megaureter
- Retrocaval ureter - anomalous IVC development causing the right ureter to pass behind the IVC ("reverse J sign" on imaging)
- Calculi, tumours, strictures
- Posterior urethral valves (in infants)
- Extrinsic compression - e.g. retroperitoneal fibrosis, pelvic malignancy
- In adults - benign prostatic hyperplasia, urethral stricture, pelvic tumours
Antenatal/paediatric hydronephrosis: Prevalence 0.6-5.4%; most cases are transient and resolve after birth. Classified into low, intermediate, and high risk; postnatal ultrasound is optimally performed at least 48 hours after birth, with diuretic renography at 4-6 weeks for functionally significant cases. High-risk infants require voiding cystourethrogram, antibiotic prophylaxis, and functional imaging.
Clinical features: May be asymptomatic (retrocaval ureter often is), or present with flank/loin pain (classically renal colic if due to stone), recurrent UTIs, a palpable renal mass, or haematuria. Chronic obstruction can present insidiously with declining renal function.
Investigations:
- Ultrasound - first-line, shows pelvicalyceal dilatation
- IVU/CT urography - defines level and cause of obstruction
- Diuretic renogram (MAG-3/DTPA) - assesses differential renal function and confirms functionally significant obstruction
- Voiding cystourethrogram - to exclude reflux/posterior urethral valves
Management: Depends on cause and severity.
- Relief of obstruction - ureteric stenting or percutaneous nephrostomy for acute/urgent decompression
- Pyeloplasty (open, laparoscopic, or robotic) - definitive treatment for PUJ obstruction
- Ureteric reimplantation for UVJ obstruction/megaureter with impaired function (<40% differential function) or recurrent UTIs
- Ureteroureterostomy or pyeloplasty for retrocaval ureter, depending on level of obstruction
- Treatment of the underlying cause - stone removal, prostate surgery, urethral dilatation/stricture repair, tumour treatment
- Nephrectomy considered if the kidney is non-functioning and symptomatic (e.g. recurrent infection, pain, hypertension)
19. COLOSTOMY
Definition: A surgically created opening of the colon onto the abdominal wall to divert faecal flow.
Types:
- Loop colostomy - a loop of colon is exteriorised and opened, leaving both afferent and efferent limbs on the surface; usually temporary, easier to close, often used for defunctioning (e.g. protecting a distal anastomosis or covering a distal obstructing lesion/fistula)
- End colostomy - proximal bowel brought out as a stoma with the distal segment either resected (e.g. abdominoperineal resection) or closed off (Hartmann's procedure); may be temporary or permanent
- Divided (double-barrel) colostomy - afferent and efferent limbs brought out separately
Indications (as reflected in Bailey and Love's discussion of benign anal stricture management): colostomy is required when a stricture (or other pathology) causes intestinal obstruction, or in advanced disease complicated by fistula-in-ano; also used in trauma, perforation, obstructing colorectal cancer, diverticular disease with perforation, and to protect a distal high-risk anastomosis. When restorative resection is anticipated later, a loop ileostomy is often preferred over colostomy as the protective stoma.
Siting and construction: Sited preoperatively away from bony prominences, skin creases, and the umbilicus, usually through the rectus abdominis to reduce parastomal herniation risk, at a point visible to the patient for self-care.
Complications:
- Early: ischaemia/necrosis, retraction, peristomal skin excoriation, high output
- Late: parastomal hernia, stomal prolapse, stenosis, retraction, and psychological/body-image impact
- Closure of a temporary colostomy carries its own risks of anastomotic leak and wound infection
Care: Stoma nurse involvement, well-fitting appliance, skin protection, and dietary advice; reversal (closure) is planned once the underlying pathology (obstruction, sepsis, distal anastomosis) has resolved or healed, generally confirmed by contrast study before closure.
Note on sourcing: content for achalasia, ileocaecal TB, ulcerative colitis, rectal prolapse, and fistula-in-ano was drawn directly from Bailey and Love's Short Practice of Surgery, 28th Edition (relevant chapters on oesophageal disease, abdominal tuberculosis, IBD, and anorectal surgery). Hydronephrosis content combines Bailey and Love's paediatric/adult urology sections (PUJ/UVJ obstruction, retrocaval ureter, antenatal hydronephrosis) with standard surgical principles for adult presentations not fully detailed in the retrieved sections. Colostomy content synthesizes Bailey and Love's brief operative references with standard stoma-care principles, since the dedicated colostomy chapter content was limited in the retrieved excerpts.
If you want, I can go deeper into any single topic (e.g. detailed surgical steps for Heller's myotomy, IPAA construction, or LIFT procedure) or pull relevant clinical images from the textbook for any of these conditions.