Cefurixime peds dose

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I have all the data needed. Here is the pediatric dosing for Cefuroxime (2nd-generation cephalosporin), from the Harriet Lane Handbook (23rd ed):

Cefuroxime — Pediatric Dosing

IV / IM

Age Group	Dose	Frequency
Neonate ≤7 days	100 mg/kg/24 hr	÷ Q12 hr
Neonate >7 days, <1 kg (8–14 days)	100 mg/kg/24 hr	÷ Q12 hr
Neonate >7 days, <1 kg (≥15 days)	150 mg/kg/24 hr	÷ Q8 hr
Neonate >7 days, ≥1 kg	150 mg/kg/24 hr	÷ Q8 hr
Infant >3 mo / Child — mild/moderate	75–100 mg/kg/24 hr	÷ Q8 hr (max 1500 mg/dose)
Infant >3 mo / Child — severe	100–200 mg/kg/24 hr	÷ Q6–8 hr (max 1500 mg/dose)

PO (Cefuroxime Axetil) — Child 3 months–12 years

Indication	Dose	Max
Pharyngitis / Tonsillitis (suspension)	20 mg/kg/24 hr ÷ Q12 hr	500 mg/24 hr
Impetigo (suspension)	30 mg/kg/24 hr ÷ Q12 hr	1 g/24 hr
Otitis media / Sinusitis (suspension)	30 mg/kg/24 hr ÷ Q12 hr	1 g/24 hr
Otitis media / Sinusitis (tablet)	250 mg BID	—
Lyme disease (suspension)	30 mg/kg/24 hr ÷ Q12 hr × 14–28 days	1 g/24 hr

PO — Child ≥13 yr / Adult

Indication	Dose
Sinusitis, otitis, pharyngitis, tonsillitis	250 mg Q12 hr
Adult (general)	250–500 mg BID

Note: The oral suspension and tablets are not bioequivalent — tablets have higher absorption (~52% vs ~37% for suspension). Do not substitute mg-for-mg.

Source: The Harriet Lane Handbook, 23rd ed., p. 1070

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