Day 1 – Emergency Medicine Case
Format: Full case with workup, diagnosis, management, and teaching points (as requested). Read it like a real ED encounter, then check the teaching points at the end and try the quiz question before scrolling to the answer.
Case Presentation
Chief complaint: "Crushing chest pain for the last hour."
A 58-year-old man presents to the Emergency Department with sudden-onset, severe substernal chest pain that began while shoveling snow. He describes it as a heavy, crushing pressure radiating to his left arm and jaw, associated with diaphoresis, nausea, and shortness of breath. Pain is 8/10, constant, not relieved by rest.
Past medical history: Hypertension, type 2 diabetes mellitus, 30-pack-year smoking history.
Medications: Amlodipine, metformin.
Family history: Father had an MI at age 55.
Vitals: BP 156/94 mmHg, HR 98 bpm, RR 22/min, SpO2 95% on room air, Temp 37.0°C.
Physical exam: Diaphoretic, anxious-appearing man in obvious distress. Lungs clear bilaterally. Heart sounds regular, no murmurs, no S3/S4 appreciated. No jugular venous distension. Abdomen soft, non-tender. No peripheral edema.
Step 1: Initial ED Actions
Any patient with chest pain concerning for acute coronary syndrome (ACS) should get a 12-lead ECG within 10 minutes of arrival - this is the single most important initial test. He is placed on a monitor, given supplemental oxygen (since SpO2 <94%), IV access is obtained, and aspirin 325 mg (chewed) is given while the ECG is being read.
ECG obtained:
- ST-segment elevations in leads V1-V4, with reciprocal ST depression in II, III, and aVF.
Per standard ECG ST-segment-based criteria for AMI (Tintinalli's Emergency Medicine, Table 49-4):
| Location | ECG findings |
|---|
| Anteroseptal | ST elevation in V1, V2, (V3) |
| Anterior | ST elevation in V1-V4 |
| Anterolateral | ST elevation V1-V6, I, aVL |
| Inferior | ST elevation II, III, aVF |
This pattern localizes to an anterior STEMI, most consistent with occlusion of the left anterior descending (LAD) artery.
Troponin is sent but reperfusion decisions should NOT wait for the result - in STEMI, the ECG alone is diagnostic and time is myocardium.
Step 2: Diagnosis
ST-Elevation Myocardial Infarction (STEMI) - anterior wall, likely LAD occlusion.
Diagnostic logic (per Tintinalli's Emergency Medicine, p. Diagnosis/Electrocardiography):
- STEMI = diagnosed by ECG in the setting of symptoms suggestive of MI (don't wait for biomarkers)
- NSTEMI = diagnosed by elevated cardiac biomarkers, ECG may or may not show ischemic changes but does not meet STEMI criteria
- Unstable angina = diagnosed clinically by history; ECG and biomarkers are nondiagnostic
Key differentials to actively exclude in any chest pain patient before anchoring on ACS:
- Aortic dissection (check for pulse/BP differentials, widened mediastinum, tearing pain to the back)
- Pulmonary embolism (pleuritic pain, tachycardia, risk factors)
- Pericarditis (positional pain, diffuse ST elevation with PR depression, friction rub)
- Tension pneumothorax, esophageal rupture
In this case, the classic exertional onset, radiation pattern, risk factors, and clear focal ECG changes make STEMI the working diagnosis with high confidence.
Step 3: Management
Immediate (MONA-BASH mnemonic, used loosely, not all four routinely given anymore):
- Aspirin 325 mg chewed - already given
- Oxygen only if SpO2 <90-94%
- Nitroglycerin sublingual for pain (avoid if hypotensive, right ventricular infarct, or recent PDE-5 inhibitor use)
- Morphine only if pain persists despite nitrates (not first-line, some data suggest it may impair antiplatelet absorption)
- Second antiplatelet - P2Y12 inhibitor (e.g., ticagrelor or clopidogrel) per local protocol, often given at time of or after cath lab activation
- Anticoagulation - heparin (unfractionated or LMWH)
- High-intensity statin
Reperfusion - the critical time-sensitive decision:
- Primary PCI is preferred if available within 90 minutes of first medical contact (door-to-balloon goal)
- If PCI is not available within that window (e.g., rural center without cath lab), fibrinolysis should be given within 30 minutes of arrival (door-to-needle goal), followed by transfer to a PCI-capable center
In our patient: the cath lab is activated immediately on ECG confirmation, cardiology is paged, and he goes for emergent PCI, where an LAD occlusion is confirmed and a stent is placed.
Disposition: CCU admission post-PCI, with continued dual antiplatelet therapy, beta-blocker, ACE inhibitor/ARB, high-intensity statin, and risk factor modification (smoking cessation, diabetes and BP control).
Teaching Points
- Time is muscle. ECG must be done and read within 10 minutes of arrival for any chest pain suggestive of ischemia - do not wait for troponin to activate the cath lab in STEMI.
- Know your STEMI territories cold - anterior (V1-V4) = LAD, inferior (II, III, aVF) = RCA (usually), lateral (I, aVL, V5-V6) = LCx. This tells you which vessel and predicts complications (e.g., inferior MI -> watch for bradycardia/heart block and right ventricular involvement).
- STEMI vs NSTEMI vs unstable angina is defined by ECG + biomarkers + history, not severity of pain.
- S3 gallop in acute MI (15-20% of patients) suggests a failing myocardium; a new systolic murmur is an ominous sign (papillary muscle rupture, VSD, acute mitral regurgitation) - always listen carefully.
- Always keep dangerous mimics (dissection, PE, pneumothorax, esophageal rupture) on your differential even when the ECG looks classic - a good history and exam narrow this fast.
Source: Tintinalli's Emergency Medicine, A Comprehensive Study Guide (ECG, Diagnosis, and Physical Examination sections on Acute Coronary Syndrome).
Quick Quiz (test yourself before reading the answer)
A 62-year-old woman presents with chest pain and her ECG shows ST elevation in leads II, III, and aVF. Which artery is most likely occluded, and what specific complication should you be extra cautious about when giving nitroglycerin?
Answer: Right coronary artery (RCA) occlusion causing an inferior MI. Nitroglycerin should be used with caution because inferior MIs are often associated with right ventricular infarction, which is preload-dependent - giving nitrates (a venodilator) can cause a severe, sudden drop in BP. Always check a right-sided ECG (V4R) and BP response before giving nitrates in suspected inferior/RV infarction.
That's Day 1. Just message me tomorrow (something like "next case") and I'll give you Day 2 - I'll rotate through different high-yield EM presentations (trauma, toxicology, pediatric emergencies, sepsis, etc.) unless you want to request a specific topic each day.