Yellow/white phosphorus rat paste poisoning is a medical emergency. Go to an emergency department/ICU immediately, even if the person feels better after initial vomiting. Serious liver failure can appear after a symptom-free period of 1 to 3 days.
This is different from organophosphate pesticide poisoning. Do not give atropine or pralidoxime unless clinicians confirm organophosphate exposure.
Symptoms
Early, minutes to 24 hours
- Burning mouth/throat or abdominal pain
- Nausea, repeated vomiting, diarrhea
- Garlic-like smell on breath or vomit
- Severe thirst, weakness
- Drowsiness, confusion, low blood sugar
- Low blood pressure, abnormal heart rhythm, collapse in severe ingestion
False recovery phase, about 1 to 3 days
- Vomiting and pain may lessen, but liver injury can be progressing silently.
Late phase, typically day 3 onward
- Jaundice, worsening vomiting, abdominal swelling/pain
- Bleeding from gums/nose, vomiting blood, black stools, bruising
- Reduced urine output or kidney injury
- Confusion, excessive sleepiness, abnormal behavior or coma from liver failure
- Seizures, shock, multi-organ failure
The classic progression is early gastrointestinal toxicity, a deceptive period of improvement, then potentially fulminant hepatic failure. P C Dikshit Textbook of Forensic Medicine and Toxicology, p. 503.
What to do immediately at home / during transport
- Call emergency services or go to the nearest ER now.
- Take the container, brand name, photo, or remaining paste with you.
- If the person is unconscious, seizing, confused, or vomiting continuously, place them on their side and do not give anything by mouth.
- Do not induce vomiting.
- Do not give milk, oil/ghee, coconut oil, alcohol, or home remedies.
- Do not attempt stomach washing at home.
Hospital management
There is
no proven specific antidote. Management is urgent decontamination when appropriate, intensive monitoring, and treatment of complications. A review on
rodenticide poisoning supports ICU observation because clinical deterioration may be delayed.
Clinicians generally need to:
- Stabilize ABCs: airway protection, oxygen/ventilation, IV access, cardiac monitoring, fluids and vasopressors if shock.
- Contact a poison center/medical toxicologist early.
- Consider activated charcoal or other gastrointestinal decontamination only under toxicology guidance, based on timing, ingestion amount, airway safety, and product formulation.
- Avoid routine potassium permanganate lavage. Older texts describe it, but contemporary literature reports safety concerns and inconsistent evidence. It should not be used at home.
- Obtain and repeat: CBC, glucose, electrolytes, renal function, AST/ALT, bilirubin, PT/INR, blood gas/lactate, ECG. Check liver and kidney function serially for at least 72 hours, often longer.
- Treat hypoglycemia, vomiting, electrolyte disturbance, bleeding/coagulopathy, acute kidney injury, arrhythmias, encephalopathy, and shock.
- If acute liver injury/failure appears, urgently transfer to a center with hepatology, ICU, and liver-transplant capability. The LTSI consensus guideline emphasizes early transplant-center evaluation, especially with worsening INR or hepatic encephalopathy. Encephalopathy of West Haven grade 2 or higher is a particularly serious transplant-listing signal.
Do not be reassured by normal early liver tests or temporary symptom improvement. This poison can cause delayed severe hepatic failure.