Rat paste poison (phosphorus) case symptoms and management?

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yellow phosphorus rat poison poisoning clinical management guideline

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https://pmc.ncbi.nlm.nih.gov/articles/PMC8267358

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"Yellow phosphorus" poisoning

Yellow/white phosphorus rat paste poisoning is a medical emergency. Go to an emergency department/ICU immediately, even if the person feels better after initial vomiting. Serious liver failure can appear after a symptom-free period of 1 to 3 days.
This is different from organophosphate pesticide poisoning. Do not give atropine or pralidoxime unless clinicians confirm organophosphate exposure.

Symptoms

Early, minutes to 24 hours
  • Burning mouth/throat or abdominal pain
  • Nausea, repeated vomiting, diarrhea
  • Garlic-like smell on breath or vomit
  • Severe thirst, weakness
  • Drowsiness, confusion, low blood sugar
  • Low blood pressure, abnormal heart rhythm, collapse in severe ingestion
False recovery phase, about 1 to 3 days
  • Vomiting and pain may lessen, but liver injury can be progressing silently.
Late phase, typically day 3 onward
  • Jaundice, worsening vomiting, abdominal swelling/pain
  • Bleeding from gums/nose, vomiting blood, black stools, bruising
  • Reduced urine output or kidney injury
  • Confusion, excessive sleepiness, abnormal behavior or coma from liver failure
  • Seizures, shock, multi-organ failure
The classic progression is early gastrointestinal toxicity, a deceptive period of improvement, then potentially fulminant hepatic failure. P C Dikshit Textbook of Forensic Medicine and Toxicology, p. 503.

What to do immediately at home / during transport

  • Call emergency services or go to the nearest ER now.
  • Take the container, brand name, photo, or remaining paste with you.
  • If the person is unconscious, seizing, confused, or vomiting continuously, place them on their side and do not give anything by mouth.
  • Do not induce vomiting.
  • Do not give milk, oil/ghee, coconut oil, alcohol, or home remedies.
  • Do not attempt stomach washing at home.

Hospital management

There is no proven specific antidote. Management is urgent decontamination when appropriate, intensive monitoring, and treatment of complications. A review on rodenticide poisoning supports ICU observation because clinical deterioration may be delayed.
Clinicians generally need to:
  1. Stabilize ABCs: airway protection, oxygen/ventilation, IV access, cardiac monitoring, fluids and vasopressors if shock.
  2. Contact a poison center/medical toxicologist early.
  3. Consider activated charcoal or other gastrointestinal decontamination only under toxicology guidance, based on timing, ingestion amount, airway safety, and product formulation.
  4. Avoid routine potassium permanganate lavage. Older texts describe it, but contemporary literature reports safety concerns and inconsistent evidence. It should not be used at home.
  5. Obtain and repeat: CBC, glucose, electrolytes, renal function, AST/ALT, bilirubin, PT/INR, blood gas/lactate, ECG. Check liver and kidney function serially for at least 72 hours, often longer.
  6. Treat hypoglycemia, vomiting, electrolyte disturbance, bleeding/coagulopathy, acute kidney injury, arrhythmias, encephalopathy, and shock.
  7. If acute liver injury/failure appears, urgently transfer to a center with hepatology, ICU, and liver-transplant capability. The LTSI consensus guideline emphasizes early transplant-center evaluation, especially with worsening INR or hepatic encephalopathy. Encephalopathy of West Haven grade 2 or higher is a particularly serious transplant-listing signal.
Do not be reassured by normal early liver tests or temporary symptom improvement. This poison can cause delayed severe hepatic failure.
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