Here is a structured clinical approach for a 22-year-old male with left fronto-temporal headache x 2 days, no trauma, hemodynamically stable, no nausea/vomiting:
Clinical Assessment
Key Features Already Present
- Young male (22 y)
- Unilateral (left-sided)
- Fronto-temporal location
- Duration: 2 days (subacute)
- No nausea/vomiting
- No trauma
- Hemodynamically stable
Step 1 - Screen for RED FLAGS (SNOOP4)
Always rule out secondary/dangerous causes first:
| Red Flag | Concern | Ask/Check |
|---|
| Systemic symptoms (fever, weight loss) | Meningitis, malignancy | Fever? Neck stiffness? |
| Neurological deficits | SOL, stroke, abscess | Any focal weakness, vision change, diplopia, speech problem? |
| Onset sudden/thunderclap | SAH | "Worst headache of life"? |
| Older age / papilledema | Raised ICP | Fundoscopy - disc margins |
| Progressive / positional | ICP, CVT | Worse on bending/Valsalva? |
| Precipitant (exertion, cough, sex) | SAH, Chiari | Onset with exertion? |
| Previous headache history change | New secondary cause | Different from prior headaches? |
This patient has NO nausea, vomiting, trauma - which makes migraine less likely (though not excluded) and favors tension-type headache as the leading diagnosis.
Step 2 - Differential Diagnosis
Most Likely: Tension-Type Headache (TTH)
IHS diagnostic criteria (all must be met):
- Duration 30 min - 7 days ✓ (2 days)
- At least 2 of 4: pressing/tightening quality, mild-moderate severity, bilateral or mild unilateral, not aggravated by routine activity
- No nausea or vomiting ✓
- Photophobia OR phonophobia (not both)
Note: This patient's headache is unilateral, which slightly reduces TTH probability. Pure TTH is typically bilateral; unilateral TTH can occur but is less characteristic.
Also Consider: Migraine Without Aura
IHS criteria (Box 89.2, Rosen's Emergency Medicine):
- Unilateral location ✓
- Pulsating quality (ask)
- Moderate-severe intensity (ask)
- Aggravated by activity (ask)
- At least 1 of: nausea/vomiting OR photophobia + phonophobia
This patient has no nausea/vomiting - migraine is less likely but NOT excluded if photophobia + phonophobia are present.
Other Differentials to Consider
| Condition | Clues |
|---|
| Sinusitis | Recent URTI, nasal congestion, tenderness over frontal/maxillary sinuses, purulent discharge |
| Cluster headache | Young male ✓, but duration 15 min-3 hrs (not 2 days), severe periorbital pain, lacrimation, rhinorrhea, agitation |
| Cervicogenic headache | Neck stiffness, pain radiating from neck, triggered by neck movement |
| Viral illness/febrile headache | Fever, myalgia, malaise |
| Raised ICP / Space-occupying lesion | Progressive course, morning headache, papilledema - unlikely but check |
| Dental/TMJ | Jaw pain, teeth clenching |
Step 3 - History to Clarify
Ask specifically:
- Quality: pressing/tight vs. pulsating/throbbing?
- Severity: 1-10 scale? Can he carry on daily activities?
- Associated: photophobia? phonophobia? visual changes? neck stiffness? fever?
- Aggravated by routine physical activity?
- Timing: continuous or intermittent? Morning or evening predominance?
- Previous episodes of similar headache?
- Nasal symptoms: congestion, discharge, facial pain/tenderness?
- Medications: any analgesic overuse?
- Stress/sleep: recent exams, poor sleep, skipped meals?
- Eye symptoms: blurred vision, redness, pain on eye movement?
Step 4 - Physical Examination
- Vitals: Temperature (rule out fever/meningitis)
- Fundoscopy: papilledema (raised ICP)?
- Meningeal signs: neck stiffness, Kernig's, Brudzinski's sign
- Neurological exam: pupil reactions, cranial nerves (especially CN II, III, IV, VI), focal deficits
- Sinus tenderness: palpate frontal and maxillary sinuses
- Temporal artery: tenderness (unlikely at 22 y, but check)
- Cervical spine: ROM, tenderness
- Eye: conjunctival injection, intraocular pressure (acute angle-closure glaucoma rare but possible)
Step 5 - Investigations
Most cases of tension/migraine headache in a young, stable patient with NO red flags do NOT require imaging.
| Investigation | When |
|---|
| No investigation | Classic tension/migraine, no red flags |
| CT head (non-contrast) | Thunderclap onset, focal neuro deficit, first/worst headache, trauma, papilledema |
| CT head + contrast / MRI | Suspected SOL, CVT, abscess |
| LP | Fever + meningismus, CT-negative thunderclap headache (r/o SAH) |
| Blood: CBC, ESR, CRP | Fever, systemic illness, temporal arteritis (not relevant at 22y) |
| Sinus X-ray / CT sinus | Strong clinical suspicion of sinusitis |
Step 6 - Management
If Tension-Type Headache (no red flags):
- First line: Paracetamol (acetaminophen) 500-1000 mg OR Ibuprofen 400 mg PO
- Advise adequate hydration, sleep, stress management
- Avoid analgesic overuse (risk of medication-overuse headache)
- Reassurance
If Migraine:
- Mild-moderate: NSAIDs (Ibuprofen 400-600 mg) + antiemetic if needed
- Moderate-severe: Sumatriptan 50-100 mg PO (triptan)
- Avoid bright lights, rest in quiet dark room
- Identify and avoid triggers (stress, sleep deprivation, skipped meals)
If Sinusitis suspected:
- Saline nasal rinse, intranasal decongestant
- Antibiotic if bacterial features present (purulent discharge, fever, facial pain >10 days)
Bottom Line
In this 22-year-old male with left fronto-temporal headache x 2 days, hemodynamically stable, no vomiting:
Most likely diagnosis: Tension-type headache (or migraine without aura if unilateral + pulsating + moderate-severe)
Priority: Rule out red flags by thorough history and neuro exam. If none present, treat symptomatically with NSAIDs, reassure, and arrange follow-up if no improvement.
- ROSEN's Emergency Medicine, p. 1462 (Headache classification, migraine criteria)
- Symptom to Diagnosis: An Evidence Based Guide, p. 370 (TTH and cluster criteria/treatment)