from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import cm
from reportlab.platypus import (
    SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle,
    HRFlowable, KeepTogether
)
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY
from reportlab.platypus import PageBreak

OUTPUT = "/home/daytona/workspace/eds-flashcards/EDS_MCQ_Flashcards.pdf"

# ── Colour palette ──────────────────────────────────────────────────────────
NAVY    = colors.HexColor("#1A2B5F")
TEAL    = colors.HexColor("#0E7B74")
AMBER   = colors.HexColor("#E8A317")
CREAM   = colors.HexColor("#FDF8EF")
RED     = colors.HexColor("#C0392B")
LTGRAY  = colors.HexColor("#F4F4F4")
MIDGRAY = colors.HexColor("#D5D5D5")
WHITE   = colors.white

doc = SimpleDocTemplate(
    OUTPUT,
    pagesize=A4,
    leftMargin=1.5*cm, rightMargin=1.5*cm,
    topMargin=1.8*cm,  bottomMargin=1.8*cm,
)

styles = getSampleStyleSheet()

# Custom paragraph styles
def S(name, parent="Normal", **kw):
    s = ParagraphStyle(name, parent=styles[parent], **kw)
    return s

title_style   = S("Title2",   fontSize=22, textColor=WHITE,   alignment=TA_CENTER, fontName="Helvetica-Bold", spaceAfter=4)
sub_style     = S("Sub",      fontSize=11, textColor=CREAM,   alignment=TA_CENTER, fontName="Helvetica",      spaceAfter=2)
section_style = S("SecHead",  fontSize=13, textColor=WHITE,   alignment=TA_LEFT,   fontName="Helvetica-Bold", spaceAfter=2, spaceBefore=2)
q_style       = S("Q",        fontSize=10, textColor=NAVY,    fontName="Helvetica-Bold", spaceAfter=3, leftIndent=4)
ans_style     = S("Ans",      fontSize=10, textColor=TEAL,    fontName="Helvetica-Bold", spaceAfter=2, leftIndent=4)
detail_style  = S("Detail",   fontSize=9,  textColor=colors.HexColor("#333333"), fontName="Helvetica", spaceAfter=1, leftIndent=12)
warn_style    = S("Warn",     fontSize=9,  textColor=RED,     fontName="Helvetica-Bold", spaceAfter=1, leftIndent=12)
note_style    = S("Note",     fontSize=8,  textColor=colors.HexColor("#555555"), fontName="Helvetica-Oblique", spaceAfter=1, leftIndent=12)
footer_style  = S("Footer",   fontSize=7,  textColor=colors.HexColor("#888888"), alignment=TA_CENTER)

def section_banner(text, color=NAVY):
    """Coloured banner row acting as section header."""
    t = Table([[Paragraph(text, section_style)]], colWidths=[17.5*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND", (0,0), (-1,-1), color),
        ("TOPPADDING",    (0,0), (-1,-1), 6),
        ("BOTTOMPADDING", (0,0), (-1,-1), 6),
        ("LEFTPADDING",   (0,0), (-1,-1), 8),
        ("ROUNDEDCORNERS", [4]),
    ]))
    return t

def flashcard(q_num, question, answer, details=None, warning=None, note=None, bg=LTGRAY):
    """Single flashcard block."""
    rows = [
        [Paragraph(f"Q{q_num}.  {question}", q_style)],
        [Paragraph(f"✔  {answer}", ans_style)],
    ]
    if details:
        for d in details:
            rows.append([Paragraph(f"• {d}", detail_style)])
    if warning:
        rows.append([Paragraph(f"⚠  {warning}", warn_style)])
    if note:
        rows.append([Paragraph(f"★  {note}", note_style)])

    t = Table(rows, colWidths=[17.5*cm])
    t.setStyle(TableStyle([
        ("BACKGROUND",    (0,0), (-1,-1), bg),
        ("TOPPADDING",    (0,0), (-1,-1), 4),
        ("BOTTOMPADDING", (0,0), (-1,-1), 4),
        ("LEFTPADDING",   (0,0), (-1,-1), 8),
        ("RIGHTPADDING",  (0,0), (-1,-1), 8),
        ("LINEBELOW",     (0,-1), (-1,-1), 0.5, MIDGRAY),
        ("ROWBACKGROUNDS",(0,0), (-1,-1), [bg]),
    ]))
    return KeepTogether([t, Spacer(1, 4)])

def subtype_table(data, headers):
    """Coloured reference table."""
    col_w = [17.5/len(headers)*cm] * len(headers)
    table_data = [headers] + data
    t = Table(table_data, colWidths=col_w, repeatRows=1)
    style = TableStyle([
        ("BACKGROUND",    (0,0), (-1,0),  NAVY),
        ("TEXTCOLOR",     (0,0), (-1,0),  WHITE),
        ("FONTNAME",      (0,0), (-1,0),  "Helvetica-Bold"),
        ("FONTSIZE",      (0,0), (-1,-1), 8),
        ("ROWBACKGROUNDS",(0,1), (-1,-1), [WHITE, LTGRAY]),
        ("GRID",          (0,0), (-1,-1), 0.4, MIDGRAY),
        ("TOPPADDING",    (0,0), (-1,-1), 4),
        ("BOTTOMPADDING", (0,0), (-1,-1), 4),
        ("LEFTPADDING",   (0,0), (-1,-1), 5),
        ("VALIGN",        (0,0), (-1,-1), "MIDDLE"),
        ("WORDWRAP",      (0,0), (-1,-1), True),
    ])
    t.setStyle(style)
    return t


# ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
story = []

# ── Cover banner ─────────────────────────────────────────────────────────────
cover = Table(
    [[Paragraph("EHLERS-DANLOS SYNDROMES", title_style)],
     [Paragraph("Quick-Reference MCQ Flashcards  |  Dermatology Board Exam", sub_style)],
     [Paragraph("2017 International Classification  •  High-Yield Points", sub_style)]],
    colWidths=[17.5*cm]
)
cover.setStyle(TableStyle([
    ("BACKGROUND",    (0,0), (-1,-1), NAVY),
    ("TOPPADDING",    (0,0), (-1,-1), 14),
    ("BOTTOMPADDING", (0,0), (-1,-1), 14),
    ("LEFTPADDING",   (0,0), (-1,-1), 12),
    ("ROUNDEDCORNERS",[6]),
]))
story.append(cover)
story.append(Spacer(1, 0.4*cm))

# ── SECTION 1: Classification & Genetics ─────────────────────────────────────
story.append(section_banner("SECTION 1 — Classification & Genetics"))
story.append(Spacer(1, 0.2*cm))

cards_s1 = [
    (1,  "How many subtypes does EDS have (2017 classification)?",
         "13 subtypes",
         ["Previous classification had 6 types (Roman numerals I-VI)",
          "2017 reclassification by Malfait et al. is the current standard"],
         None,
         "Combined incidence ~1 in 5,000 births"),

    (2,  "Which collagen is defective in Classical EDS?",
         "Type V collagen — COL5A1 / COL5A2 genes",
         ["Inheritance: Autosomal Dominant",
          "Most common identifiable gene defect in EDS"],
         None,
         "Type V collagen regulates fibril diameter"),

    (3,  "Which collagen is defective in Vascular EDS?",
         "Type III collagen — COL3A1 gene",
         ["Inheritance: Autosomal Dominant",
          "COL3A1 = homotrimer; one mutant chain disrupts most fibrils",
          ">320 different mutations described (missense / exon-skipping)"],
         "Most LETHAL subtype — risk of spontaneous arterial/organ rupture",
         "Incidence: 1 in 50,000–200,000"),

    (4,  "Which enzyme is deficient in Kyphoscoliotic EDS?",
         "Lysyl hydroxylase (PLOD1 gene)",
         ["Reduced hydroxylation of lysyl residues in types I & III collagen",
          "Interferes with collagen crosslink formation",
          "Inheritance: Autosomal Recessive"],
         None,
         "Only common EDS subtype that is AR due to enzyme deficiency"),

    (5,  "Which EDS subtype is caused by ADAMTS2 mutation?",
         "Dermatosparaxis EDS",
         ["ADAMTS2 = procollagen N-peptidase",
          "Leads to extreme skin fragility and sagging/redundant skin",
          "Inheritance: Autosomal Recessive"],
         None,
         "Dermatosparaxis = 'tearing of skin' in Greek"),

    (6,  "Which EDS subtype has an UNKNOWN causative gene?",
         "Hypermobile EDS (hEDS)",
         ["Most common EDS subtype overall",
          "Diagnosis is purely clinical — no genetic test available",
          "~5% show TNXB heterozygous mutations (intermediate phenotype)"],
         None,
         "Hypermobility + musculoskeletal pain + autonomic features"),

    (7,  "Classical-like EDS is caused by deficiency of which protein?",
         "Tenascin-X (TNXB gene)",
         ["Inheritance: Autosomal Recessive",
          "Phenotype similar to classical EDS but WITHOUT atrophic scars",
          "TNXB is located near CYP21A2 (congenital adrenal hyperplasia gene)"],
         None,
         "Micro-deletions affecting both TNXB + CYP21A2 reported"),

    (8,  "Which EDS subtype is associated with severe mitral AND aortic valve disease?",
         "Cardiac-Valvular EDS",
         ["Gene: COL1A2 (type I collagen)",
          "Inheritance: Autosomal Recessive",
          "Progressive valvular insufficiency is the hallmark"],
         None,
         None),
]

for c in cards_s1:
    story.append(flashcard(*c))

story.append(Spacer(1, 0.3*cm))

# ── Subtype quick-reference table ────────────────────────────────────────────
story.append(section_banner("QUICK-REFERENCE TABLE — EDS Subtypes (Key MCQ Points)", color=TEAL))
story.append(Spacer(1, 0.2*cm))

headers = [
    Paragraph("<b>Subtype</b>", ParagraphStyle("th", fontSize=8, textColor=WHITE, fontName="Helvetica-Bold")),
    Paragraph("<b>Gene / Protein</b>", ParagraphStyle("th", fontSize=8, textColor=WHITE, fontName="Helvetica-Bold")),
    Paragraph("<b>Inheritance</b>", ParagraphStyle("th", fontSize=8, textColor=WHITE, fontName="Helvetica-Bold")),
    Paragraph("<b>Key Feature / MCQ Hook</b>", ParagraphStyle("th", fontSize=8, textColor=WHITE, fontName="Helvetica-Bold")),
]

cell = lambda txt, bold=False: Paragraph(txt, ParagraphStyle("cell", fontSize=8,
    fontName="Helvetica-Bold" if bold else "Helvetica", leading=10))

table_data = [
    [cell("Classical",True),          cell("COL5A1/COL5A2\n(Type V collagen)"), cell("AD"), cell("Skin hyperextensibility + atrophic 'cigarette paper' scars")],
    [cell("Classical-like",True),     cell("TNXB\n(Tenascin-X)"),              cell("AR"), cell("Like classical but NO atrophic scars")],
    [cell("Cardiac-Valvular",True),   cell("COL1A2\n(Type I collagen)"),        cell("AR"), cell("Severe mitral + aortic valve disease")],
    [cell("Vascular",True),           cell("COL3A1\n(Type III collagen)"),      cell("AD"), cell("Arterial / colon / uterine rupture — MOST LETHAL")],
    [cell("Hypermobile",True),        cell("Unknown"),                           cell("AD"), cell("Most COMMON; joint hypermobility dominant; no gene test")],
    [cell("Arthrochalasia",True),     cell("COL1A1/COL1A2\n(Type I collagen)"), cell("AD"), cell("Congenital bilateral hip dislocation at birth")],
    [cell("Dermatosparaxis",True),    cell("ADAMTS2\n(procollagen N-peptidase)"),cell("AR"), cell("Extreme skin fragility; sagging redundant skin")],
    [cell("Kyphoscoliotic",True),     cell("PLOD1\n(Lysyl hydroxylase)"),        cell("AR"), cell("Congenital scoliosis + ocular fragility (corneal rupture)")],
    [cell("Brittle Cornea",True),     cell("ZNF469 / PRDM5"),                   cell("AR"), cell("Corneal rupture; keratoconus")],
    [cell("Spondylodysplastic",True), cell("B4GALT7 / B3GALT6"),               cell("AR"), cell("Short stature + skeletal dysplasia")],
    [cell("Musculocontractural",True),cell("CHST14 / DSE"),                    cell("AR"), cell("Multiple congenital contractures + characteristic facies")],
    [cell("Myopathic",True),          cell("COL12A1\n(Type XII collagen)"),      cell("AD/AR"), cell("Congenital hypotonia + muscle atrophy")],
    [cell("Periodontal",True),        cell("C1R / C1S\n(Complement proteins)"), cell("AD"), cell("Severe early-onset periodontitis + pretibial plaques")],
]

story.append(subtype_table(table_data, headers))
story.append(Spacer(1, 0.4*cm))
story.append(PageBreak())

# ── SECTION 2: Skin Signs ─────────────────────────────────────────────────────
story.append(section_banner("SECTION 2 — Skin Signs & Examination"))
story.append(Spacer(1, 0.2*cm))

cards_s2 = [
    (9,  "What is the cutoff for positive skin hyperextensibility on volar forearm?",
         ">1.5 cm on distal forearm / dorsal hands",
         [">3 cm at neck, elbow, or knees is also positive",
          "Assessed using Remvig et al. criteria",
          "Pull skin at non-scarred, non-force-bearing site until resistance"],
         None,
         "Skin recoils to normal after release — differentiates from cutis laxa"),

    (10, "What type of scar is pathognomonic for Classical EDS?",
         "Thin, atrophic, 'cigarette paper' / 'papyraceous' scars",
         ["Wounds gape easily, heal poorly",
          "Minor injuries cause disproportionately large gaping defects",
          "Surgical repair is extremely difficult due to poor tensile strength"],
         None,
         None),

    (11, "What are molluscoid pseudotumors in EDS?",
         "Soft, fibrous subcutaneous nodules over pressure points (e.g., elbows, knees)",
         ["Consist of fibrous tissue + fat",
          "Can calcify over time",
          "Seen in Classical EDS"],
         None,
         "Also called 'spheroids' when calcified"),

    (12, "What does routine skin biopsy show in EDS?",
         "NORMAL histopathology on light microscopy",
         ["Electron microscopy (EM) is needed to demonstrate abnormal collagen fibrils",
          "EM shows irregular fibril size, 'cauliflower' fibrils in some subtypes"],
         None,
         "Classic MCQ trap: normal biopsy does NOT rule out EDS"),

    (13, "What skin texture is classically described in Classical EDS?",
         "Soft, velvety, doughy skin",
         ["Skin is hyperextensible but NOT lax at rest",
          "Contrast with cutis laxa: skin hangs loosely even at rest"],
         None,
         None),

    (14, "What skin finding is characteristic of Vascular EDS?",
         "Thin, translucent skin with visible subcutaneous veins",
         ["Acrogeria: premature aged appearance of hands/feet",
          "Characteristic facial features: thin nose, small ears, sunken cheeks",
          "Minimal joint hypermobility (unlike other subtypes)"],
         "Skin fragility WITHOUT the hyperextensibility typical of other subtypes",
         None),
]

for c in cards_s2:
    story.append(flashcard(*c))

story.append(Spacer(1, 0.3*cm))

# ── SECTION 3: Labs & Diagnosis ──────────────────────────────────────────────
story.append(section_banner("SECTION 3 — Labs, Diagnosis & Investigations"))
story.append(Spacer(1, 0.2*cm))

cards_s3 = [
    (15, "What do platelet function and coagulation tests show in EDS?",
         "NORMAL — PT, aPTT, platelets are all normal",
         ["Bruising results from structural weakness of vessel walls",
          "NOT a coagulopathy"],
         "High-yield MCQ trap: easy bruising + normal coagulation = EDS",
         None),

    (16, "What scoring system is used to assess joint hypermobility in EDS?",
         "Beighton Score (maximum 9 points)",
         ["5 maneuvers: little finger extension, thumb to forearm,",
          "elbow hyperextension, knee hyperextension, palms flat on floor",
          "Score ≥5/9 in adults = generalised joint hypermobility"],
         None,
         "Beighton score alone is NOT diagnostic — must combine with clinical criteria"),

    (17, "What is the preferred genetic investigation for EDS workup?",
         "Next-generation sequencing (NGS) panel of known EDS genes",
         ["Tests multiple EDS-causing genes simultaneously",
          "If negative: copy number variant (CNV) analysis or whole-exome sequencing",
          "Genetic diagnosis not possible for hEDS (no gene identified)"],
         None,
         None),

    (18, "How is Vascular EDS confirmed biochemically?",
         "Type III procollagen analysis from cultured fibroblasts + COL3A1 mutation testing",
         ["Cultured fibroblasts show reduced type III collagen production",
          "Direct COL3A1 sequencing detects >95% of mutations",
          "Exon-skipping and missense mutations most common"],
         None,
         None),

    (19, "Which EDS subtype can be diagnosed by measuring urinary hydroxylysine?",
         "Kyphoscoliotic EDS — reduced urinary hydroxylysine:lysine ratio",
         ["Due to deficient lysyl hydroxylase (PLOD1)",
          "This biochemical test can screen before genetic confirmation"],
         None,
         "Neonatal hypotonia + scoliosis + ocular fragility → check urine"),
]

for c in cards_s3:
    story.append(flashcard(*c))

story.append(Spacer(1, 0.3*cm))

# ── SECTION 4: Complications ──────────────────────────────────────────────────
story.append(section_banner("SECTION 4 — Complications by Subtype"))
story.append(Spacer(1, 0.2*cm))

cards_s4 = [
    (20, "Which EDS subtype causes arterial rupture, colon perforation, uterine rupture?",
         "Vascular EDS (COL3A1 mutation)",
         ["Spontaneous rupture without preceding trauma",
          "Medium and large vessels most affected",
          "Median survival historically ~50 years"],
         "Most common cause of death in EDS overall",
         "Avoid invasive procedures; imaging surveillance of aorta essential"),

    (21, "Which EDS subtype causes corneal rupture and retinal detachment?",
         "Kyphoscoliotic EDS (lysyl hydroxylase deficiency)",
         ["Ocular fragility is a hallmark feature",
          "Also: congenital scoliosis, muscle hypotonia",
          "Inheritance: AR"],
         None,
         None),

    (22, "Which EDS subtype presents with congenital bilateral hip dislocation?",
         "Arthrochalasia EDS (COL1A1 or COL1A2 mutation)",
         ["Congenital hip dislocation is the hallmark",
          "Severe generalized joint hypermobility",
          "Inheritance: AD"],
         None,
         None),

    (23, "Which EDS subtype causes severe periodontitis and pretibial plaques?",
         "Periodontal EDS (C1R / C1S mutations)",
         ["Complement pathway proteins C1r and C1s affected",
          "Early-onset severe gingival/periodontal destruction",
          "Pretibial hemosiderin plaques are characteristic",
          "Inheritance: AD"],
         None,
         None),

    (24, "Diaphragmatic hernia is a known complication of which EDS subtype?",
         "Classical EDS",
         ["Type V collagen defect weakens connective tissue of diaphragm",
          "May present in neonates as respiratory distress"],
         None,
         None),
]

for c in cards_s4:
    story.append(flashcard(*c))

story.append(Spacer(1, 0.3*cm))
story.append(PageBreak())

# ── SECTION 5: Differentials & Traps ─────────────────────────────────────────
story.append(section_banner("SECTION 5 — Key Differentials & MCQ Traps"))
story.append(Spacer(1, 0.2*cm))

cards_s5 = [
    (25, "How does EDS skin differ from cutis laxa on examination?",
         "EDS: skin snaps back after stretching. Cutis laxa: skin hangs loosely.",
         ["Cutis laxa = elastin defect (ELN, FBLN5 genes)",
          "Cutis laxa: skin sags at rest, aged appearance",
          "EDS: skin elastic, recoils normally at rest"],
         None,
         "Mnemonic: EDS = Elastic snap. Cutis Laxa = Loose/Lax and hangs"),

    (26, "How do you differentiate EDS from Marfan syndrome?",
         "Marfan: FBN1 (fibrillin-1), tall stature, UPWARD lens dislocation, no skin hyperextensibility",
         ["EDS: collagen gene, normal height, normal lens",
          "Marfan: arachnodactyly, dolichocephaly, high-arched palate",
          "Both can have aortic root dilation and joint laxity"],
         None,
         "Ectopia lentis in Marfan = upward; in homocystinuria = downward"),

    (27, "A patient has easy bruising but normal PT, aPTT, and platelet count. Diagnosis?",
         "Ehlers-Danlos Syndrome (structural vessel wall weakness)",
         ["Rule out: von Willebrand disease (platelet function analyzer may be abnormal)",
          "Rule out: Scurvy (perifollicular hemorrhage, corkscrew hairs)",
          "Senile purpura: elderly, dorsal forearms"],
         None,
         "EDS bruising = structural, not hemostatic"),

    (28, "Which EDS subtype has the UNKNOWN gene but is the MOST COMMON?",
         "Hypermobile EDS (hEDS)",
         ["No confirmed causative gene",
          "Diagnosis by clinical criteria only (2017 nosology)",
          "Associated with dysautonomia, chronic pain, POTS"],
         None,
         "hEDS ≠ Joint Hypermobility Syndrome (JHS) — they overlap but differ"),

    (29, "Celiprolol (beta-blocker) has RCT evidence in which EDS subtype?",
         "Vascular EDS — reduces rate of arterial complications",
         ["Celiprolol is a selective beta-1 blocker with beta-2 agonist properties",
          "Reduces shear stress on vessel walls",
          "One RCT (Ong et al.) showed 36% vs 50% event rate"],
         None,
         "Celiprolol specific to vascular EDS; not indicated for other subtypes"),

    (30, "Most contortionists are said to have which condition?",
         "A mild form of EDS (joint hypermobility)",
         ["Hypermobile joints allow extreme ranges of motion",
          "Joint dislocation is the 'price paid' for virtuosity (Robbins)",
          "Beighton score would be very high in these individuals"],
         None,
         "Classic Robbins exam statement"),
]

for c in cards_s5:
    story.append(flashcard(*c))

story.append(Spacer(1, 0.3*cm))

# ── SECTION 6: Management One-Liners ─────────────────────────────────────────
story.append(section_banner("SECTION 6 — Management High-Yield Points"))
story.append(Spacer(1, 0.2*cm))

mgmt_data = [
    ["Vascular EDS surveillance", "Regular CT/MRI of aorta and major vessels annually"],
    ["Drug therapy — Vascular EDS", "Celiprolol (RCT evidence); avoid invasive procedures"],
    ["Wound management", "Deep sutures + prolonged wound closure; warn all surgeons"],
    ["Joint protection", "Physiotherapy, low-impact exercise, bracing; avoid contact sports"],
    ["Cardiac workup", "Echocardiography for aortic root dilation + valve assessment"],
    ["Pregnancy in vascular EDS", "High-risk OB; significant maternal mortality risk"],
    ["Genetics", "Cascade testing of first-degree relatives after diagnosis"],
    ["Kyphoscoliotic EDS — Vitamin C", "High-dose Vitamin C may partially support hydroxylation"],
    ["No curative treatment", "All EDS management is SYMPTOMATIC and PREVENTIVE"],
]

mgmt_headers = [
    Paragraph("<b>Area</b>", ParagraphStyle("th2", fontSize=8, textColor=WHITE, fontName="Helvetica-Bold")),
    Paragraph("<b>Key Point</b>", ParagraphStyle("th2", fontSize=8, textColor=WHITE, fontName="Helvetica-Bold")),
]
mgmt_cells = [[cell(r[0], bold=True), cell(r[1])] for r in mgmt_data]
t = Table([mgmt_headers] + mgmt_cells, colWidths=[5*cm, 12.5*cm], repeatRows=1)
t.setStyle(TableStyle([
    ("BACKGROUND",    (0,0), (-1,0),  NAVY),
    ("TEXTCOLOR",     (0,0), (-1,0),  WHITE),
    ("FONTSIZE",      (0,0), (-1,-1), 8),
    ("ROWBACKGROUNDS",(0,1), (-1,-1), [WHITE, LTGRAY]),
    ("GRID",          (0,0), (-1,-1), 0.4, MIDGRAY),
    ("TOPPADDING",    (0,0), (-1,-1), 5),
    ("BOTTOMPADDING", (0,0), (-1,-1), 5),
    ("LEFTPADDING",   (0,0), (-1,-1), 6),
    ("VALIGN",        (0,0), (-1,-1), "MIDDLE"),
]))
story.append(t)
story.append(Spacer(1, 0.5*cm))

# ── Footer strip ──────────────────────────────────────────────────────────────
footer_banner = Table(
    [[Paragraph("Sources: Robbins & Kumar Basic Pathology • Andrews' Diseases of the Skin • Fitzpatrick's Dermatology • Goldman-Cecil Medicine  |  Classification: Malfait et al. 2017", footer_style)]],
    colWidths=[17.5*cm]
)
footer_banner.setStyle(TableStyle([
    ("BACKGROUND",    (0,0), (-1,-1), colors.HexColor("#EBEBEB")),
    ("TOPPADDING",    (0,0), (-1,-1), 5),
    ("BOTTOMPADDING", (0,0), (-1,-1), 5),
    ("LEFTPADDING",   (0,0), (-1,-1), 8),
]))
story.append(footer_banner)

# ── Build ──────────────────────────────────────────────────────────────────────
doc.build(story)
print(f"PDF created: {OUTPUT}")