from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import mm
from reportlab.pdfgen import canvas
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.platypus import SimpleDocTemplate, Paragraph, Spacer, HRFlowable
from reportlab.lib.enums import TA_CENTER, TA_LEFT

W, H = A4

def make_sample():
    path = "/home/daytona/workspace/dnb-pathophysiology/SAMPLE_Topic15_MH.pdf"
    c = canvas.Canvas(path, pagesize=A4)

    # ── palette ──────────────────────────────────────────────────────────────
    BG        = colors.HexColor("#0D1B2A")   # dark navy background
    HEADER_BG = colors.HexColor("#1B3A5C")   # slightly lighter header
    ACCENT    = colors.HexColor("#F4A261")   # warm orange arrows / highlights
    BOX_BG    = colors.HexColor("#132233")   # box background
    BOX_BORDER= colors.HexColor("#2E6DA4")   # box border
    TEXT_MAIN = colors.HexColor("#E8F4FD")   # near-white text
    TEXT_DIM  = colors.HexColor("#A8C7E0")   # secondary text
    STAR_COL  = colors.HexColor("#F4A261")   # star colour
    PEARL_BG  = colors.HexColor("#1A3C1A")   # dark green for anaesthetic pearl
    PEARL_BOR = colors.HexColor("#4CAF50")   # green border

    # ── full-page dark background ─────────────────────────────────────────────
    c.setFillColor(BG)
    c.rect(0, 0, W, H, fill=1, stroke=0)

    # ── top header bar ────────────────────────────────────────────────────────
    c.setFillColor(HEADER_BG)
    c.rect(0, H - 28*mm, W, 28*mm, fill=1, stroke=0)

    # accent line under header
    c.setFillColor(ACCENT)
    c.rect(0, H - 29*mm, W, 1.5, fill=1, stroke=0)

    # header text
    c.setFillColor(ACCENT)
    c.setFont("Helvetica-Bold", 9)
    c.drawString(12*mm, H - 10*mm, "DNB ANAESTHESIOLOGY — PATHOPHYSIOLOGY FLOWCHARTS  |  2021-2025")

    c.setFillColor(TEXT_MAIN)
    c.setFont("Helvetica-Bold", 17)
    c.drawString(12*mm, H - 21*mm, "Topic 15 — Malignant Hyperthermia (MH)")

    # frequency stars
    c.setFillColor(STAR_COL)
    c.setFont("Helvetica-Bold", 11)
    c.drawRightString(W - 12*mm, H - 21*mm, "★★★  High Priority")

    # ── helper: draw a flowchart box ──────────────────────────────────────────
    def draw_box(x, y, w, h, title, lines, title_color=ACCENT, bg=BOX_BG, border=BOX_BORDER):
        # shadow
        c.setFillColor(colors.HexColor("#000000"))
        c.setFillAlpha(0.25)
        c.rect(x+1.5, y-1.5, w, h, fill=1, stroke=0)
        c.setFillAlpha(1.0)
        # box
        c.setFillColor(bg)
        c.setStrokeColor(border)
        c.setLineWidth(1.2)
        c.roundRect(x, y, w, h, 4, fill=1, stroke=1)
        # title
        c.setFillColor(title_color)
        c.setFont("Helvetica-Bold", 9)
        c.drawString(x + 5, y + h - 13, title)
        # content lines
        c.setFillColor(TEXT_MAIN)
        c.setFont("Helvetica", 8)
        for i, line in enumerate(lines):
            c.drawString(x + 5, y + h - 24 - i*11, line)

    def draw_arrow(x, y_top, length=18):
        """Draw a vertical downward arrow centred at x."""
        c.setStrokeColor(ACCENT)
        c.setFillColor(ACCENT)
        c.setLineWidth(1.8)
        c.line(x, y_top, x, y_top - length + 6)
        # arrowhead (triangle)
        p = c.beginPath()
        p.moveTo(x, y_top - length)
        p.lineTo(x - 4, y_top - length + 8)
        p.lineTo(x + 4, y_top - length + 8)
        p.close()
        c.drawPath(p, fill=1, stroke=0)

    cx = W / 2   # horizontal centre
    bw = 155*mm  # box width
    bx = cx - bw/2

    # ── flowchart boxes ───────────────────────────────────────────────────────
    # 1. TRIGGER
    y1 = H - 60*mm
    bh1 = 22*mm
    draw_box(bx, y1, bw, bh1,
             "① TRIGGER — Genetic Susceptibility",
             ["RYR1 gene mutation (Ryanodine Receptor 1 on chromosome 19q)",
              "Autosomal dominant  |  Incidence ~1:10,000–15,000 anaesthetics"])
    draw_arrow(cx, y1, 18)

    # 2. INITIATING AGENT
    y2 = y1 - 18*mm - 22*mm
    bh2 = 22*mm
    draw_box(bx, y2, bw, bh2,
             "② INITIATING AGENT (Triggers)",
             ["Volatile anaesthetics (halothane > sevoflurane > isoflurane > desflurane)",
              "Succinylcholine (depolarising NMB)  |  Stress / heat (rare)"])
    draw_arrow(cx, y2, 18)

    # 3. PATHOLOGICAL MECHANISM
    y3 = y2 - 18*mm - 28*mm
    bh3 = 28*mm
    draw_box(bx, y3, bw, bh3,
             "③ CORE MECHANISM — Uncontrolled Ca²⁺ Release",
             ["Trigger → RYR1 channel opens uncontrollably in SR",
              "Massive Ca²⁺ floods sarcoplasm → sustained muscle contraction",
              "ATP consumed at extreme rate → hypermetabolism",
              "Anaerobic glycolysis → lactic acidosis + heat generation"])
    draw_arrow(cx, y3, 18)

    # 4. CLINICAL CASCADE
    y4 = y3 - 18*mm - 32*mm
    bh4 = 32*mm
    draw_box(bx, y4, bw, bh4,
             "④ CLINICAL CASCADE (in order of appearance)",
             ["EARLIEST: ↑ETCO2 (↑↑ CO2 production)  + Masseter spasm (sux)",
              "↑ HR, ↑ BP, muscle rigidity (generalised)",
              "Hyperthermia (rises ~1°C / 5 min — LATE sign)",
              "Metabolic acidosis  |  Hyperkalaemia (cell membrane breakdown)",
              "Rhabdomyolysis → myoglobinuria → AKI"])
    draw_arrow(cx, y4, 18)

    # 5. TREATMENT
    y5 = y4 - 18*mm - 36*mm
    bh5 = 36*mm
    draw_box(bx, y5, bw, bh5,
             "⑤ TREATMENT — MHAUS Protocol",
             ["STOP all volatile agents + succinylcholine immediately",
              "Hyperventilate 100% O₂ at 2-3× MV (↓ ETCO2)",
              "DANTROLENE 2.5 mg/kg IV bolus → repeat q5 min (max 10 mg/kg)",
              "   MOA: blocks RYR1 → ↓ Ca²⁺ release from SR",
              "Cool patient (ice packs / cold IV fluids) → target 38.5°C",
              "Treat hyperkalaemia (calcium / insulin-glucose / bicarb)",
              "Monitor: ETCO2, temperature, ABG, CK, urine output"],
             title_color=PEARL_BOR, bg=PEARL_BG, border=PEARL_BOR)

    # ── bottom memory hook ────────────────────────────────────────────────────
    yb = y5 - 12*mm
    c.setFillColor(colors.HexColor("#2C1810"))
    c.setStrokeColor(ACCENT)
    c.setLineWidth(1)
    c.roundRect(bx, yb - 12*mm, bw, 14*mm, 4, fill=1, stroke=1)
    c.setFillColor(ACCENT)
    c.setFont("Helvetica-Bold", 9)
    c.drawString(bx + 5, yb - 5, "⚡ MEMORY HOOK:  ETCO₂ UP first → Dantrolene is the ONLY cure → Stop triggers IMMEDIATELY")

    # ── footer ────────────────────────────────────────────────────────────────
    c.setFillColor(HEADER_BG)
    c.rect(0, 0, W, 12*mm, fill=1, stroke=0)
    c.setFillColor(ACCENT)
    c.rect(0, 12*mm, W, 0.8, fill=1, stroke=0)
    c.setFillColor(TEXT_DIM)
    c.setFont("Helvetica", 7.5)
    c.drawString(12*mm, 4.5*mm, "DNB Anaesthesiology Pathophysiology Flowcharts  |  Sample — Topic 15 of 90")
    c.drawRightString(W - 12*mm, 4.5*mm, "For Exam Revision Only")

    c.save()
    print("Saved:", path)

make_sample()

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import mm
from reportlab.pdfgen import canvas

W, H = A4

def draw_page(c, topic_num, topic_title, freq_label, steps, pearl, memory):
    """
    steps = list of (step_label, [bullet, bullet, ...])
    pearl = string (anaesthetic implication)
    memory = string (memory hook)
    """

    # ── colours ───────────────────────────────────────────────────────────────
    C_HEADER   = colors.HexColor("#1A56DB")   # blue header
    C_STEP_BG  = colors.HexColor("#EFF6FF")   # very light blue box
    C_STEP_BOR = colors.HexColor("#93C5FD")   # soft blue border
    C_ARROW    = colors.HexColor("#1A56DB")
    C_PEARL_BG = colors.HexColor("#F0FDF4")   # mint green
    C_PEARL_BOR= colors.HexColor("#4ADE80")
    C_MEM_BG   = colors.HexColor("#FFFBEB")   # warm yellow
    C_MEM_BOR  = colors.HexColor("#FCD34D")
    C_TEXT     = colors.HexColor("#1E293B")   # near-black
    C_SUB      = colors.HexColor("#475569")   # grey subtitle

    # ── white background ──────────────────────────────────────────────────────
    c.setFillColor(colors.white)
    c.rect(0, 0, W, H, fill=1, stroke=0)

    # ── header strip ─────────────────────────────────────────────────────────
    c.setFillColor(C_HEADER)
    c.rect(0, H - 22*mm, W, 22*mm, fill=1, stroke=0)

    c.setFillColor(colors.white)
    c.setFont("Helvetica-Bold", 16)
    c.drawString(12*mm, H - 13*mm, f"Topic {topic_num}  —  {topic_title}")

    c.setFont("Helvetica", 9)
    c.drawRightString(W - 12*mm, H - 10*mm, freq_label)
    c.setFont("Helvetica", 8)
    c.drawRightString(W - 12*mm, H - 17*mm, "DNB Anaesthesiology | Pathophysiology Flowchart")

    # ── helper: arrow ─────────────────────────────────────────────────────────
    def arrow(x, y_top, length=14):
        c.setStrokeColor(C_ARROW)
        c.setFillColor(C_ARROW)
        c.setLineWidth(2)
        c.line(x, y_top, x, y_top - length + 5)
        p = c.beginPath()
        p.moveTo(x, y_top - length)
        p.lineTo(x - 5, y_top - length + 9)
        p.lineTo(x + 5, y_top - length + 9)
        p.close()
        c.drawPath(p, fill=1, stroke=0)

    # ── helper: step box ──────────────────────────────────────────────────────
    def step_box(y, label, bullets, bg=C_STEP_BG, bor=C_STEP_BOR):
        bw = W - 28*mm
        bx = 14*mm
        pad = 4*mm
        line_h = 6.5*mm
        bh = 9*mm + len(bullets) * line_h + pad

        c.setFillColor(bg)
        c.setStrokeColor(bor)
        c.setLineWidth(1.2)
        c.roundRect(bx, y - bh, bw, bh, 5, fill=1, stroke=1)

        # label pill
        c.setFillColor(C_HEADER)
        pill_w = c.stringWidth(label, "Helvetica-Bold", 8.5) + 8
        c.roundRect(bx + 5*mm, y - 7.5*mm, pill_w, 5.5*mm, 3, fill=1, stroke=0)
        c.setFillColor(colors.white)
        c.setFont("Helvetica-Bold", 8.5)
        c.drawString(bx + 5*mm + 4, y - 4.5*mm, label)

        # bullets
        c.setFillColor(C_TEXT)
        c.setFont("Helvetica", 10)
        for i, b in enumerate(bullets):
            bullet_y = y - 10*mm - i * line_h
            c.setFillColor(C_ARROW)
            c.circle(bx + 6*mm, bullet_y + 2, 1.8, fill=1, stroke=0)
            c.setFillColor(C_TEXT)
            c.drawString(bx + 9*mm, bullet_y, b)

        return bh   # return height used

    # ── lay out flowchart steps ───────────────────────────────────────────────
    cx = W / 2
    cur_y = H - 26*mm   # start just below header

    for i, (label, bullets) in enumerate(steps):
        cur_y -= 6*mm   # top margin before box
        bh = step_box(cur_y, label, bullets)
        cur_y -= bh
        if i < len(steps) - 1:
            arrow(cx, cur_y, 14)
            cur_y -= 2*mm

    # ── anaesthetic pearl ─────────────────────────────────────────────────────
    cur_y -= 5*mm
    bw = W - 28*mm
    bx = 14*mm
    pearl_h = 16*mm
    c.setFillColor(C_PEARL_BG)
    c.setStrokeColor(C_PEARL_BOR)
    c.setLineWidth(1.5)
    c.roundRect(bx, cur_y - pearl_h, bw, pearl_h, 5, fill=1, stroke=1)
    c.setFillColor(colors.HexColor("#15803D"))
    c.setFont("Helvetica-Bold", 9)
    c.drawString(bx + 5*mm, cur_y - 6*mm, "Anaesthetic Implication")
    c.setFillColor(C_TEXT)
    c.setFont("Helvetica", 10)
    c.drawString(bx + 5*mm, cur_y - 12.5*mm, pearl)
    cur_y -= pearl_h

    # ── memory hook ──────────────────────────────────────────────────────────
    cur_y -= 4*mm
    mem_h = 13*mm
    c.setFillColor(C_MEM_BG)
    c.setStrokeColor(C_MEM_BOR)
    c.setLineWidth(1.2)
    c.roundRect(bx, cur_y - mem_h, bw, mem_h, 5, fill=1, stroke=1)
    c.setFillColor(colors.HexColor("#92400E"))
    c.setFont("Helvetica-Bold", 9)
    c.drawString(bx + 5*mm, cur_y - 6*mm, "Memory Hook")
    c.setFillColor(C_TEXT)
    c.setFont("Helvetica-Oblique", 9.5)
    c.drawString(bx + 5*mm, cur_y - 11.5*mm, memory)

    # ── footer ────────────────────────────────────────────────────────────────
    c.setStrokeColor(colors.HexColor("#CBD5E1"))
    c.setLineWidth(0.5)
    c.line(12*mm, 10*mm, W - 12*mm, 10*mm)
    c.setFillColor(C_SUB)
    c.setFont("Helvetica", 7.5)
    c.drawString(12*mm, 6*mm, f"Topic {topic_num} of 90  |  DNB Anaesthesiology Pathophysiology Flowcharts")
    c.drawRightString(W - 12*mm, 6*mm, "For Exam Revision Only")


# ── SAMPLE: Topic 15 — Malignant Hyperthermia ────────────────────────────────
path = "/home/daytona/workspace/dnb-pathophysiology/SAMPLE_v2_Topic15_MH.pdf"
c = canvas.Canvas(path, pagesize=A4)

draw_page(
    c,
    topic_num=15,
    topic_title="Malignant Hyperthermia",
    freq_label="★★★  High Priority  |  Asked Dec22, Dec25, Oct23",
    steps=[
        ("TRIGGER — Genetic Basis",
         ["RYR1 gene mutation (chromosome 19q13)  —  Autosomal Dominant",
          "Incidence: ~1 : 10,000–15,000 anaesthetics"]),

        ("INITIATING AGENTS",
         ["All volatile anaesthetics  (halothane > sevo > iso > des)",
          "Succinylcholine (depolarising NMB)"]),

        ("CORE DEFECT  —  Uncontrolled Ca²⁺ Release",
         ["Trigger opens RYR1 channel → massive SR Ca²⁺ release",
          "Sustained muscle contraction → extreme ATP consumption",
          "Anaerobic glycolysis → lactic acid + ↑↑ heat"]),

        ("CLINICAL CASCADE  (in sequence)",
         ["① ↑↑ EtCO₂  (EARLIEST sign)  +  masseter spasm",
          "② Tachycardia, hypertension, generalised rigidity",
          "③ Hyperthermia (rises ~1°C/5 min — LATE)",
          "④ Metabolic acidosis, hyperkalaemia",
          "⑤ Rhabdomyolysis → myoglobinuria → AKI"]),

        ("TREATMENT — MHAUS Protocol",
         ["STOP trigger agent + succinylcholine  |  Call for help",
          "Hyperventilate 100% O₂ at 2–3× minute volume",
          "DANTROLENE 2.5 mg/kg IV q5 min  (max 10 mg/kg)",
          "Active cooling → target 38.5°C",
          "Treat K⁺ & acidosis  |  Urine output > 1 ml/kg/h"]),
    ],
    pearl="Avoid all volatiles & succinylcholine. Use TIVA (propofol + remi). Have dantrolene stocked.",
    memory="EtCO₂ FIRST → Dantrolene is the ONLY cure → STOP trigger → Cool"
)

c.save()
print("Saved:", path)

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import mm
from reportlab.pdfgen import canvas

W, H = A4

def wrap_text(text, max_chars=70):
    """Simple word-wrap into lines of max_chars."""
    words = text.split()
    lines = []
    cur = ""
    for w in words:
        if len(cur) + len(w) + 1 <= max_chars:
            cur = (cur + " " + w).strip()
        else:
            if cur:
                lines.append(cur)
            cur = w
    if cur:
        lines.append(cur)
    return lines

def draw_flowchart_page(c, topic_num, topic_title, freq, flow_steps, anaesthetic_points):
    """
    flow_steps: list of strings (each is one step in the flow)
    anaesthetic_points: list of strings
    """

    FONT_MONO  = "Courier"
    FONT_BOLD  = "Helvetica-Bold"
    FONT_REG   = "Helvetica"

    C_TITLE    = colors.HexColor("#374151")   # dark grey title
    C_FREQ     = colors.HexColor("#6B7280")   # lighter grey freq
    C_BOX_BG   = colors.HexColor("#F1F5F9")   # very light grey box (like reference)
    C_ANESTH_BG= colors.HexColor("#F0FDF4")   # very light green
    C_TEXT     = colors.HexColor("#111827")   # near black
    C_ARROW    = colors.HexColor("#374151")   # dark grey arrow
    C_BORDER   = colors.HexColor("#CBD5E1")   # subtle border
    C_GREEN    = colors.HexColor("#15803D")

    # White page
    c.setFillColor(colors.white)
    c.rect(0, 0, W, H, fill=1, stroke=0)

    margin_l = 14*mm
    margin_r = W - 14*mm
    box_w    = W - 28*mm

    cur_y = H - 14*mm

    # ── Topic title ───────────────────────────────────────────────────────────
    c.setFillColor(C_TITLE)
    c.setFont(FONT_BOLD, 15)
    c.drawString(margin_l, cur_y, f"Topic {topic_num}. {topic_title.upper()}  —  PATHOPHYSIOLOGY FLOWCHART")
    cur_y -= 5*mm

    # Frequency line
    c.setFillColor(C_FREQ)
    c.setFont(FONT_REG, 9)
    c.drawString(margin_l, cur_y, freq)
    cur_y -= 4*mm

    # thin rule
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.7)
    c.line(margin_l, cur_y, margin_r, cur_y)
    cur_y -= 5*mm

    # ── Build full text block for flowchart box ───────────────────────────────
    # Each step may need wrapping; between steps insert a ↓ line
    FONT_SIZE  = 11
    LINE_H     = 6.5*mm
    ARROW_H    = 6*mm
    PAD_V      = 5*mm
    PAD_H      = 8*mm

    # Pre-compute all display lines
    display_lines = []  # list of (text, is_arrow)
    for i, step in enumerate(flow_steps):
        wrapped = wrap_text(step, max_chars=68)
        for ln in wrapped:
            display_lines.append((ln, False))
        if i < len(flow_steps) - 1:
            display_lines.append(("↓", True))

    total_flow_h = PAD_V + len(display_lines) * LINE_H + PAD_V

    # Draw box
    box_y = cur_y - total_flow_h
    c.setFillColor(C_BOX_BG)
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.8)
    c.roundRect(margin_l, box_y, box_w, total_flow_h, 4, fill=1, stroke=1)

    # Draw lines inside box
    text_x = margin_l + PAD_H
    text_y = cur_y - PAD_V - LINE_H * 0.15

    for (line, is_arrow) in display_lines:
        if is_arrow:
            c.setFillColor(C_ARROW)
            c.setFont(FONT_MONO, FONT_SIZE + 1)
            c.drawString(text_x + 30, text_y, line)
        else:
            c.setFillColor(C_TEXT)
            c.setFont(FONT_MONO, FONT_SIZE)
            c.drawString(text_x, text_y, line)
        text_y -= LINE_H

    cur_y = box_y - 6*mm

    # ── Anaesthetic Implication box ───────────────────────────────────────────
    c.setFillColor(C_GREEN)
    c.setFont(FONT_BOLD, 10)
    c.drawString(margin_l, cur_y, "ANAESTHETIC IMPLICATIONS")
    cur_y -= 4*mm

    # pre-compute lines
    anesth_lines = []
    for pt in anaesthetic_points:
        wrapped = wrap_text("• " + pt, max_chars=68)
        anesth_lines.extend(wrapped)

    anesth_h = PAD_V + len(anesth_lines) * LINE_H + PAD_V
    abox_y = cur_y - anesth_h

    c.setFillColor(C_ANESTH_BG)
    c.setStrokeColor(colors.HexColor("#86EFAC"))
    c.setLineWidth(0.8)
    c.roundRect(margin_l, abox_y, box_w, anesth_h, 4, fill=1, stroke=1)

    ty = cur_y - PAD_V - LINE_H * 0.15
    for ln in anesth_lines:
        c.setFillColor(C_TEXT)
        c.setFont(FONT_MONO, FONT_SIZE)
        c.drawString(text_x, ty, ln)
        ty -= LINE_H

    cur_y = abox_y - 5*mm

    # ── Footer ────────────────────────────────────────────────────────────────
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.5)
    c.line(margin_l, 10*mm, margin_r, 10*mm)
    c.setFillColor(C_FREQ)
    c.setFont(FONT_REG, 7.5)
    c.drawString(margin_l, 6.5*mm, f"Topic {topic_num} of 90  |  DNB Anaesthesiology Pathophysiology Flowcharts  |  Exam Revision")
    c.drawRightString(margin_r, 6.5*mm, "2021–2025 Question Bank")


# ── SAMPLE: Topic 15 — Malignant Hyperthermia ────────────────────────────────
path = "/home/daytona/workspace/dnb-pathophysiology/SAMPLE_v3_Topic15_MH.pdf"
c = canvas.Canvas(path, pagesize=A4)

draw_flowchart_page(
    c,
    topic_num   = 15,
    topic_title = "Malignant Hyperthermia",
    freq        = "★★★  High Priority  |  Asked: Dec 2022, Dec 2025, Oct 2023",
    flow_steps  = [
        "RYR1 gene mutation (chromosome 19q13) — Autosomal Dominant",
        "Exposure to volatile anaesthetic (halothane > sevo > iso > des) OR succinylcholine",
        "RYR1 channel opens uncontrollably → massive Ca²⁺ release from sarcoplasmic reticulum",
        "Sustained muscle contraction → extreme ATP consumption → hypermetabolism",
        "Anaerobic glycolysis → lactic acidosis + massive heat generation",
        "↑↑ EtCO₂ (EARLIEST sign) + masseter spasm",
        "Tachycardia, hypertension, generalised muscle rigidity",
        "Hyperthermia (rises ~1°C per 5 min — LATE sign)",
        "Hyperkalaemia + metabolic acidosis",
        "Rhabdomyolysis → myoglobinuria → AKI + cardiac arrhythmias",
    ],
    anaesthetic_points = [
        "STOP volatile agent + succinylcholine immediately. Call for help.",
        "Hyperventilate with 100% O₂ at 2-3× minute volume.",
        "DANTROLENE 2.5 mg/kg IV bolus, repeat q5 min up to 10 mg/kg (blocks RYR1).",
        "Active cooling: ice packs, cold IV fluids — target temperature 38.5°C.",
        "Treat hyperkalaemia (calcium gluconate, insulin-glucose, bicarb).",
        "Use TIVA (propofol + remifentanil) — avoid all volatiles in susceptible patients.",
        "Have dantrolene stocked (36 vials minimum). Screen family (MHAUS protocol).",
    ]
)

c.save()
print("Saved:", path)

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import mm
from reportlab.pdfgen import canvas

W, H = A4

def wrap_text(text, max_chars=70):
    words = text.split()
    lines = []
    cur = ""
    for w in words:
        if len(cur) + len(w) + 1 <= max_chars:
            cur = (cur + " " + w).strip()
        else:
            if cur:
                lines.append(cur)
            cur = w
    if cur:
        lines.append(cur)
    return lines

def draw_flowchart_page(c, topic_num, topic_title, freq, flow_steps, anaesthetic_points):

    FONT_MONO  = "Courier"
    FONT_BOLD  = "Helvetica-Bold"
    FONT_REG   = "Helvetica"

    C_TITLE    = colors.HexColor("#1E293B")
    C_FREQ     = colors.HexColor("#64748B")
    C_BOX_BG   = colors.HexColor("#F1F5F9")
    C_ANESTH_BG= colors.HexColor("#F0FDF4")
    C_TEXT     = colors.HexColor("#0F172A")
    C_ARROW    = colors.HexColor("#334155")
    C_BORDER   = colors.HexColor("#CBD5E1")
    C_GREEN_TXT= colors.HexColor("#166534")
    C_GREEN_BOR= colors.HexColor("#86EFAC")
    C_ACCENT   = colors.HexColor("#1D4ED8")   # blue for topic title accent line

    c.setFillColor(colors.white)
    c.rect(0, 0, W, H, fill=1, stroke=0)

    margin_l = 16*mm
    margin_r = W - 16*mm
    box_w    = W - 32*mm
    FONT_SIZE = 11
    LINE_H    = 7*mm
    PAD_V     = 5*mm
    PAD_H     = 7*mm

    cur_y = H - 12*mm

    # Blue accent bar left of title
    c.setFillColor(C_ACCENT)
    c.rect(margin_l, cur_y - 11*mm, 3, 13*mm, fill=1, stroke=0)

    # Topic title
    c.setFillColor(C_TITLE)
    c.setFont(FONT_BOLD, 14)
    c.drawString(margin_l + 6, cur_y, f"Topic {topic_num}. {topic_title.upper()}")
    cur_y -= 6*mm

    # Subtitle: Pathophysiology Flowchart
    c.setFillColor(C_ACCENT)
    c.setFont(FONT_BOLD, 9)
    c.drawString(margin_l + 6, cur_y, "PATHOPHYSIOLOGY FLOWCHART")
    cur_y -= 5*mm

    # Frequency
    c.setFillColor(C_FREQ)
    c.setFont(FONT_REG, 8.5)
    c.drawString(margin_l + 6, cur_y, freq)
    cur_y -= 4*mm

    # Divider
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.8)
    c.line(margin_l, cur_y, margin_r, cur_y)
    cur_y -= 6*mm

    # ── Build display lines ───────────────────────────────────────────────────
    display_lines = []
    for i, step in enumerate(flow_steps):
        wrapped = wrap_text(step, max_chars=66)
        for ln in wrapped:
            display_lines.append((ln, False))
        if i < len(flow_steps) - 1:
            display_lines.append(("       |", True))  # arrow line

    total_flow_h = PAD_V + len(display_lines) * LINE_H + PAD_V

    # Draw grey box
    box_y = cur_y - total_flow_h
    c.setFillColor(C_BOX_BG)
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.8)
    c.roundRect(margin_l, box_y, box_w, total_flow_h, 5, fill=1, stroke=1)

    # Draw text inside box
    text_x = margin_l + PAD_H
    text_y  = cur_y - PAD_V - LINE_H * 0.3

    for (line, is_arrow) in display_lines:
        if is_arrow:
            # Draw a proper downward arrow using lines + triangle
            ax = margin_l + PAD_H + 18
            c.setStrokeColor(C_ARROW)
            c.setFillColor(C_ARROW)
            c.setLineWidth(1.5)
            c.line(ax, text_y + 3*mm, ax, text_y - 0.5*mm)
            # arrowhead
            p = c.beginPath()
            p.moveTo(ax,     text_y - 1.5*mm)
            p.lineTo(ax - 4, text_y + 1.5*mm)
            p.lineTo(ax + 4, text_y + 1.5*mm)
            p.close()
            c.drawPath(p, fill=1, stroke=0)
        else:
            c.setFillColor(C_TEXT)
            c.setFont(FONT_MONO, FONT_SIZE)
            c.drawString(text_x, text_y, line)
        text_y -= LINE_H

    cur_y = box_y - 7*mm

    # ── Anaesthetic Implications ──────────────────────────────────────────────
    c.setFillColor(C_GREEN_TXT)
    c.setFont(FONT_BOLD, 10)
    c.drawString(margin_l, cur_y, "ANAESTHETIC IMPLICATIONS")
    cur_y -= 5*mm

    anesth_lines = []
    for pt in anaesthetic_points:
        wrapped = wrap_text("* " + pt, max_chars=66)
        anesth_lines.extend(wrapped)

    anesth_h = PAD_V + len(anesth_lines) * LINE_H + PAD_V
    abox_y = cur_y - anesth_h

    c.setFillColor(C_ANESTH_BG)
    c.setStrokeColor(C_GREEN_BOR)
    c.setLineWidth(0.8)
    c.roundRect(margin_l, abox_y, box_w, anesth_h, 5, fill=1, stroke=1)

    ty = cur_y - PAD_V - LINE_H * 0.3
    for ln in anesth_lines:
        c.setFillColor(C_TEXT)
        c.setFont(FONT_MONO, FONT_SIZE)
        c.drawString(text_x, ty, ln)
        ty -= LINE_H

    cur_y = abox_y

    # ── Footer ────────────────────────────────────────────────────────────────
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.5)
    c.line(margin_l, 11*mm, margin_r, 11*mm)
    c.setFillColor(C_FREQ)
    c.setFont(FONT_REG, 7.5)
    c.drawString(margin_l, 7*mm,
                 f"Topic {topic_num} of 90  |  DNB Anaesthesiology Pathophysiology Flowcharts")
    c.drawRightString(margin_r, 7*mm, "2021-2025 Question Bank")


# ── SAMPLE: Topic 15 — Malignant Hyperthermia ────────────────────────────────
path = "/home/daytona/workspace/dnb-pathophysiology/SAMPLE_v4_Topic15_MH.pdf"
c = canvas.Canvas(path, pagesize=A4)

draw_flowchart_page(
    c,
    topic_num   = 15,
    topic_title = "Malignant Hyperthermia",
    freq        = "High Priority (3x)  |  Asked: Dec 2022, Dec 2025, Oct 2023",
    flow_steps  = [
        "RYR1 gene mutation (chromosome 19q13) -- Autosomal Dominant",
        "Exposure to volatile anaesthetic (halothane > sevo > iso > des) OR succinylcholine",
        "RYR1 channel opens uncontrollably --> massive Ca2+ release from sarcoplasmic reticulum",
        "Sustained muscle contraction --> extreme ATP consumption --> hypermetabolism",
        "Anaerobic glycolysis --> lactic acidosis + massive heat generation",
        "EtCO2 rises sharply (EARLIEST sign) + masseter spasm after sux",
        "Tachycardia + hypertension + generalised muscle rigidity",
        "Hyperthermia (rises ~1 deg C per 5 min -- LATE sign)",
        "Hyperkalaemia + severe metabolic acidosis",
        "Rhabdomyolysis --> myoglobinuria --> AKI + cardiac arrhythmias --> death if untreated",
    ],
    anaesthetic_points = [
        "STOP volatile agent + succinylcholine immediately. Activate MH protocol.",
        "Hyperventilate with 100% O2 at 2-3x minute volume to wash out CO2.",
        "DANTROLENE 2.5 mg/kg IV bolus, repeat every 5 min (max 10 mg/kg). MOA: blocks RYR1.",
        "Active cooling: ice packs, cold IV saline -- target temp 38.5 deg C.",
        "Treat hyperkalaemia: calcium gluconate + insulin-glucose + sodium bicarbonate.",
        "Use TIVA (propofol + remifentanil) in susceptible patients -- avoid ALL volatiles.",
        "Stock minimum 36 vials dantrolene. Screen family members (MHAUS protocol).",
    ]
)

c.save()
print("Saved:", path)

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import mm
from reportlab.pdfgen import canvas

W, H = A4

def wrap_text(text, max_chars=65):
    words = text.split()
    lines, cur = [], ""
    for w in words:
        if len(cur) + len(w) + 1 <= max_chars:
            cur = (cur + " " + w).strip()
        else:
            if cur: lines.append(cur)
            cur = w
    if cur: lines.append(cur)
    return lines

def draw_page(c, topic_num, topic_title, freq, flow_steps, anaesthetic_points):
    # ── colours (matching reference image palette) ────────────────────────────
    C_BG       = colors.white
    C_BOX      = colors.HexColor("#EAECF0")   # same grey as reference
    C_ABOX     = colors.HexColor("#F0FDF4")   # light green
    C_TITLE    = colors.HexColor("#374151")   # dark grey title
    C_FREQ     = colors.HexColor("#6B7280")
    C_TEXT     = colors.HexColor("#111827")
    C_ARROW    = colors.HexColor("#374151")
    C_BORDER   = colors.HexColor("#D1D5DB")
    C_ABORDER  = colors.HexColor("#A7F3D0")
    C_ATITLE   = colors.HexColor("#065F46")

    FONT       = "Courier"
    FONT_BOLD  = "Helvetica-Bold"
    FONT_REG   = "Helvetica"
    FS         = 11.5      # main font size
    LH         = 7.2*mm    # line height
    PAD        = 6*mm      # vertical padding inside box
    PADH       = 8*mm      # horizontal padding inside box
    ML         = 16*mm     # left margin
    MR         = W - 16*mm

    # White background
    c.setFillColor(C_BG)
    c.rect(0, 0, W, H, fill=1, stroke=0)

    cur_y = H - 14*mm

    # ── Title ─────────────────────────────────────────────────────────────────
    c.setFillColor(C_TITLE)
    c.setFont(FONT_BOLD, 14)
    title_str = f"Topic {topic_num}. {topic_title.upper()} -- PATHOPHYSIOLOGY FLOWCHART"
    c.drawString(ML, cur_y, title_str)
    cur_y -= 6*mm

    # Frequency
    c.setFillColor(C_FREQ)
    c.setFont(FONT_REG, 8.5)
    c.drawString(ML, cur_y, freq)
    cur_y -= 5*mm

    # Thin rule
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.7)
    c.line(ML, cur_y, MR, cur_y)
    cur_y -= 7*mm

    BOX_W = MR - ML

    # ── Build flow lines ──────────────────────────────────────────────────────
    flow_lines = []   # list of (text, is_arrow)
    for i, step in enumerate(flow_steps):
        for ln in wrap_text(step, 63):
            flow_lines.append((ln, False))
        if i < len(flow_steps) - 1:
            flow_lines.append(("DOWN_ARROW", True))

    flow_h = PAD + len(flow_lines) * LH + PAD

    # Grey box
    c.setFillColor(C_BOX)
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.7)
    c.roundRect(ML, cur_y - flow_h, BOX_W, flow_h, 4, fill=1, stroke=1)

    ty = cur_y - PAD - LH * 0.25
    cx = ML + BOX_W / 2

    for (line, is_arrow) in flow_lines:
        if is_arrow:
            # Draw centred down arrow: vertical bar + arrowhead
            ax = cx
            top = ty + LH * 0.65
            bot = ty - LH * 0.05
            c.setStrokeColor(C_ARROW)
            c.setFillColor(C_ARROW)
            c.setLineWidth(1.4)
            c.line(ax, top, ax, bot + 3)
            # arrowhead triangle
            p = c.beginPath()
            p.moveTo(ax,     bot)
            p.lineTo(ax - 5, bot + 9)
            p.lineTo(ax + 5, bot + 9)
            p.close()
            c.drawPath(p, fill=1, stroke=0)
        else:
            c.setFillColor(C_TEXT)
            c.setFont(FONT, FS)
            c.drawString(ML + PADH, ty, line)
        ty -= LH

    cur_y = cur_y - flow_h - 8*mm

    # ── Anaesthetic Implications section ─────────────────────────────────────
    c.setFillColor(C_ATITLE)
    c.setFont(FONT_BOLD, 10.5)
    c.drawString(ML, cur_y, "ANAESTHETIC IMPLICATIONS")
    cur_y -= 5*mm

    alines = []
    for pt in anaesthetic_points:
        for ln in wrap_text("- " + pt, 63):
            alines.append(ln)

    abox_h = PAD + len(alines) * LH + PAD

    c.setFillColor(C_ABOX)
    c.setStrokeColor(C_ABORDER)
    c.setLineWidth(0.7)
    c.roundRect(ML, cur_y - abox_h, BOX_W, abox_h, 4, fill=1, stroke=1)

    ty = cur_y - PAD - LH * 0.25
    for ln in alines:
        c.setFillColor(C_TEXT)
        c.setFont(FONT, FS)
        c.drawString(ML + PADH, ty, ln)
        ty -= LH

    # ── Footer ────────────────────────────────────────────────────────────────
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.5)
    c.line(ML, 11*mm, MR, 11*mm)
    c.setFillColor(C_FREQ)
    c.setFont(FONT_REG, 7.5)
    c.drawString(ML, 7*mm, f"Topic {topic_num} of 90  |  DNB Anaesthesiology Pathophysiology  |  2021-2025")
    c.drawRightString(MR, 7*mm, "Exam Revision")


# ── SAMPLE: Topic 15 — Malignant Hyperthermia ────────────────────────────────
path = "/home/daytona/workspace/dnb-pathophysiology/SAMPLE_v5_Topic15_MH.pdf"
c = canvas.Canvas(path, pagesize=A4)

draw_page(
    c,
    topic_num  = 15,
    topic_title= "Malignant Hyperthermia",
    freq       = "High Priority (3x asked)  |  Dec 2022, Dec 2025, Oct 2023",
    flow_steps = [
        "RYR1 gene mutation (chr 19q13) -- Autosomal Dominant",
        "Exposure to volatile agent (halothane > sevo > iso > des) OR succinylcholine",
        "RYR1 channel opens uncontrollably",
        "Massive Ca2+ release from sarcoplasmic reticulum into sarcoplasm",
        "Sustained skeletal muscle contraction -- extreme ATP consumption",
        "Anaerobic glycolysis -- lactic acidosis + massive heat generation",
        "EtCO2 rises sharply (EARLIEST sign) + masseter spasm after sux",
        "Tachycardia + hypertension + generalised muscle rigidity",
        "Hyperthermia (rises ~1 deg C per 5 min -- LATE sign)",
        "Hyperkalaemia + severe metabolic acidosis",
        "Rhabdomyolysis --> myoglobinuria --> AKI + cardiac arrhythmias --> death if untreated",
    ],
    anaesthetic_points = [
        "STOP volatile agent + succinylcholine immediately. Call for help.",
        "Hyperventilate 100% O2 at 2-3x minute volume to blow off CO2.",
        "DANTROLENE 2.5 mg/kg IV bolus q5 min, max 10 mg/kg (blocks RYR1 channel).",
        "Active cooling: ice packs + cold IV saline -- target 38.5 deg C.",
        "Treat hyperkalaemia: calcium gluconate + insulin-glucose + NaHCO3.",
        "Use TIVA (propofol + remifentanil) in susceptible patients -- avoid all volatiles.",
        "Stock min 36 vials dantrolene. Screen family members (MHAUS protocol).",
    ]
)

c.save()
print("Saved:", path)

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import mm
from reportlab.pdfgen import canvas

W, H = A4

def wrap(text, max_chars=62):
    words = text.split()
    lines, cur = [], ""
    for w in words:
        if len(cur) + len(w) + 1 <= max_chars:
            cur = (cur + " " + w).strip()
        else:
            if cur: lines.append(cur)
            cur = w
    if cur: lines.append(cur)
    return lines

def draw_page(c, topic_num, topic_title, freq, steps, anaesthetic_lines):
    """
    steps: list of (BOLD_TITLE, subtitle_or_None)
           e.g. ("TRIGGER", "(Pneumonia / Sepsis / Aspiration / Trauma)")
           subtitle can be None for steps with no sub-line
    anaesthetic_lines: list of plain strings shown at bottom (no bold title needed,
                       the section header is drawn automatically)
    """

    # ── Fonts & colours ───────────────────────────────────────────────────────
    F_TITLE  = "Helvetica-Bold"
    F_STEP   = "Helvetica-Bold"   # BOLD step titles
    F_SUB    = "Helvetica"        # subtitle / bracket text
    F_MONO   = "Courier"          # body / implication text

    C_TITLE  = colors.HexColor("#1F2937")
    C_RULE   = colors.HexColor("#9CA3AF")
    C_BOX    = colors.HexColor("#F3F4F6")   # very light grey -- matches reference
    C_BORDER = colors.HexColor("#D1D5DB")
    C_TEXT   = colors.HexColor("#111827")
    C_SUB    = colors.HexColor("#374151")
    C_ARROW  = colors.HexColor("#374151")
    C_ATITLE = colors.HexColor("#065F46")   # dark green for ANAESTHETIC IMPLICATION header
    C_FREQ   = colors.HexColor("#6B7280")

    FS_STEP  = 11.5   # bold step title size
    FS_SUB   = 10.5   # subtitle size
    FS_IMP   = 10.5   # implication text size
    LH_STEP  = 6.8*mm
    LH_SUB   = 6.2*mm
    LH_ARR   = 8*mm   # height reserved for arrow row
    PAD_V    = 5*mm
    PAD_H    = 10*mm
    ML       = 15*mm
    MR       = W - 15*mm
    BOX_W    = MR - ML

    # White page
    c.setFillColor(colors.white)
    c.rect(0, 0, W, H, fill=1, stroke=0)

    cur_y = H - 13*mm

    # ── Topic heading ─────────────────────────────────────────────────────────
    c.setFillColor(C_TITLE)
    c.setFont(F_TITLE, 13.5)
    c.drawString(ML, cur_y, f"Topic {topic_num}. {topic_title.upper()} PATHOPHYSIOLOGY FLOWCHART")
    cur_y -= 5.5*mm

    # Frequency
    c.setFillColor(C_FREQ)
    c.setFont(F_SUB, 8.5)
    c.drawString(ML, cur_y, freq)
    cur_y -= 5*mm

    # ── Pre-calculate all rows inside the single big box ──────────────────────
    # Each step produces: step-title row + optional sub rows + arrow row
    # Last step: no arrow row; instead separator + ANAESTHETIC IMPLICATION header + implication rows

    rows = []   # each item: ("step", text) | ("sub", text) | ("arrow",) | ("sep",) | ("atitle",) | ("aimp", text)

    for i, (title, subtitle) in enumerate(steps):
        rows.append(("step", title))
        if subtitle:
            for ln in wrap(subtitle, 60):
                rows.append(("sub", ln))
        if i < len(steps) - 1:
            rows.append(("arrow",))

    # Separator before anaesthetic implication
    rows.append(("sep",))
    rows.append(("atitle", "ANAESTHETIC IMPLICATION"))
    for pt in anaesthetic_lines:
        for ln in wrap(pt, 60):
            rows.append(("aimp", ln))

    # Measure total box height
    def row_height(r):
        if r[0] == "step":   return LH_STEP
        if r[0] == "sub":    return LH_SUB
        if r[0] == "arrow":  return LH_ARR
        if r[0] == "sep":    return 5*mm
        if r[0] == "atitle": return LH_STEP + 2*mm
        if r[0] == "aimp":   return LH_SUB
        return LH_SUB

    total_h = PAD_V + sum(row_height(r) for r in rows) + PAD_V

    box_y = cur_y - total_h

    # Draw single box
    c.setFillColor(C_BOX)
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.8)
    c.roundRect(ML, box_y, BOX_W, total_h, 4, fill=1, stroke=1)

    # Horizontal rule just below topic title inside box (like reference ━━━━)
    rule_y = cur_y - PAD_V * 0.3
    c.setStrokeColor(C_RULE)
    c.setLineWidth(1.2)
    c.line(ML + 4, rule_y, MR - 4, rule_y)

    # Draw rows
    cx  = ML + BOX_W / 2
    tx  = ML + PAD_H
    ty  = cur_y - PAD_V

    for r in rows:
        kind = r[0]

        if kind == "step":
            c.setFillColor(C_TEXT)
            c.setFont(F_STEP, FS_STEP)
            c.drawString(tx, ty, r[1])
            ty -= LH_STEP

        elif kind == "sub":
            c.setFillColor(C_SUB)
            c.setFont(F_SUB, FS_SUB)
            c.drawString(tx, ty, r[1])
            ty -= LH_SUB

        elif kind == "arrow":
            # centred down arrow
            mid = ty - LH_ARR * 0.25
            top = ty - 1*mm
            bot = ty - LH_ARR + 3*mm
            c.setStrokeColor(C_ARROW)
            c.setFillColor(C_ARROW)
            c.setLineWidth(1.5)
            c.line(cx, top, cx, bot + 4)
            p = c.beginPath()
            p.moveTo(cx,     bot)
            p.lineTo(cx - 5, bot + 9)
            p.lineTo(cx + 5, bot + 9)
            p.close()
            c.drawPath(p, fill=1, stroke=0)
            ty -= LH_ARR

        elif kind == "sep":
            # horizontal divider before implication
            c.setStrokeColor(C_RULE)
            c.setLineWidth(0.7)
            c.line(ML + 4, ty, MR - 4, ty)
            ty -= 5*mm

        elif kind == "atitle":
            c.setFillColor(C_ATITLE)
            c.setFont(F_STEP, FS_STEP)
            c.drawString(tx, ty, r[1])
            ty -= LH_STEP + 2*mm

        elif kind == "aimp":
            c.setFillColor(C_TEXT)
            c.setFont(F_SUB, FS_IMP)
            c.drawString(tx, ty, r[1])
            ty -= LH_SUB

    # ── Footer ────────────────────────────────────────────────────────────────
    c.setStrokeColor(C_BORDER)
    c.setLineWidth(0.5)
    c.line(ML, 11*mm, MR, 11*mm)
    c.setFillColor(C_FREQ)
    c.setFont(F_SUB, 7.5)
    c.drawString(ML, 7*mm, f"Topic {topic_num} of 90  |  DNB Anaesthesiology Pathophysiology  |  2021-2025")
    c.drawRightString(MR, 7*mm, "Exam Revision")


# ── SAMPLE: Topic 15 -- Malignant Hyperthermia ───────────────────────────────
path = "/home/daytona/workspace/dnb-pathophysiology/SAMPLE_v6_Topic15_MH.pdf"
c = canvas.Canvas(path, pagesize=A4)

draw_page(
    c,
    topic_num   = 15,
    topic_title = "Malignant Hyperthermia",
    freq        = "High Priority (3x asked)  |  Dec 2022, Dec 2025, Oct 2023",
    steps = [
        ("TRIGGER -- Genetic Susceptibility",
         "(RYR1 gene mutation, chr 19q13 -- Autosomal Dominant)"),

        ("INITIATING AGENT",
         "(Volatile: halothane > sevo > iso > des  OR  Succinylcholine)"),

        ("RYR1 CHANNEL OPENS UNCONTROLLABLY",
         "(Massive Ca2+ floods sarcoplasm from sarcoplasmic reticulum)"),

        ("SUSTAINED MUSCLE CONTRACTION",
         "(Extreme ATP consumption --> hypermetabolism)"),

        ("ANAEROBIC GLYCOLYSIS",
         "(Lactic acidosis + massive heat generation)"),

        ("EtCO2 RISES SHARPLY  <-- EARLIEST SIGN",
         "(+ Masseter spasm after succinylcholine)"),

        ("TACHYCARDIA + HYPERTENSION + RIGIDITY",
         None),

        ("HYPERTHERMIA  <-- LATE SIGN",
         "(Rises ~1 deg C per 5 min)"),

        ("HYPERKALAEMIA + SEVERE METABOLIC ACIDOSIS",
         None),

        ("RHABDOMYOLYSIS",
         "(Myoglobinuria --> AKI + cardiac arrhythmias --> death if untreated)"),
    ],
    anaesthetic_lines = [
        "STOP volatile agent + succinylcholine immediately. Call for help.",
        "Hyperventilate 100% O2 at 2-3x MV to blow off CO2.",
        "DANTROLENE 2.5 mg/kg IV q5 min (max 10 mg/kg) -- blocks RYR1.",
        "Active cooling: ice packs + cold IV saline -- target 38.5 deg C.",
        "Treat K+: calcium gluconate + insulin-glucose + NaHCO3.",
        "TIVA (propofol + remifentanil) in susceptible patients -- NO volatiles.",
        "Stock min 36 vials dantrolene. Family screening via MHAUS protocol.",
    ]
)

c.save()
print("Saved:", path)

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import mm
from reportlab.pdfgen import canvas

W, H = A4

def wrap(text, max_chars=58):
    words = text.split()
    lines, cur = [], ""
    for w in words:
        if len(cur) + len(w) + 1 <= max_chars:
            cur = (cur + " " + w).strip()
        else:
            if cur: lines.append(cur)
            cur = w
    if cur: lines.append(cur)
    return lines

def draw_page(c, topic_num, topic_title, freq, flow_steps, anaesthetic_lines):
    """
    flow_steps: list of plain strings (one per step, like the reference image)
    anaesthetic_lines: list of plain strings
    """

    # ── exact colours from reference image ───────────────────────────────────
    C_TITLE  = colors.HexColor("#4B5563")   # grey title text (outside box)
    C_BOX    = colors.HexColor("#E8ECF0")   # light grey box fill - same as reference
    C_TEXT   = colors.HexColor("#1C1C1E")   # near-black body text
    C_ARROW  = colors.HexColor("#374151")   # arrow colour
    C_FREQ   = colors.HexColor("#9CA3AF")   # small freq text
    C_ATITLE = colors.HexColor("#374151")   # anaesthetic section title
    C_ABOX   = colors.HexColor("#E8ECF0")   # same grey for anaesthetic box

    FONT     = "Courier"                    # monospace - exactly like reference
    FONT_HB  = "Helvetica-Bold"            # for outside title only

    FS       = 12       # font size - matches reference
    LH       = 7.5*mm   # line height
    ARR_H    = 7*mm     # height of arrow row
    PAD_V    = 7*mm     # vertical padding inside box
    PAD_H    = 7*mm     # horizontal padding inside box
    ARR_X    = 45       # x position of arrow from left edge of box (indented like reference)

    ML  = 14*mm
    MR  = W - 14*mm
    BW  = MR - ML       # box width

    # White page
    c.setFillColor(colors.white)
    c.rect(0, 0, W, H, fill=1, stroke=0)

    cur_y = H - 14*mm

    # ── Title OUTSIDE box (grey bold, like reference) ─────────────────────────
    c.setFillColor(C_TITLE)
    c.setFont(FONT_HB, 13)
    c.drawString(ML, cur_y, f"{topic_title.upper()} PATHOPHYSIOLOGY FLOWCHART")
    cur_y -= 5.5*mm

    # Frequency line
    c.setFillColor(C_FREQ)
    c.setFont("Helvetica", 8.5)
    c.drawString(ML, cur_y, freq)
    cur_y -= 7*mm

    # ── Build all display rows ────────────────────────────────────────────────
    rows = []   # ("text", str) | ("arrow",)
    for i, step in enumerate(flow_steps):
        for ln in wrap(step, 56):
            rows.append(("text", ln))
        if i < len(flow_steps) - 1:
            rows.append(("arrow",))

    # measure flow box height
    flow_h = PAD_V + sum(LH if r[0]=="text" else ARR_H for r in rows) + PAD_V

    # Draw flow box (no stroke/border - just fill, like reference)
    c.setFillColor(C_BOX)
    c.roundRect(ML, cur_y - flow_h, BW, flow_h, 6, fill=1, stroke=0)

    # Draw rows
    tx = ML + PAD_H
    ty = cur_y - PAD_V

    for (kind, *rest) in rows:
        if kind == "text":
            ty -= LH
            c.setFillColor(C_TEXT)
            c.setFont(FONT, FS)
            c.drawString(tx, ty + 2, rest[0])
        else:  # arrow
            # small ↓ indented ~like reference (about 8 chars in)
            ty -= ARR_H
            c.setFillColor(C_ARROW)
            c.setFont(FONT, FS + 1)
            c.drawString(tx + ARR_X, ty + 3, "v")  # plain v as arrow - clean
            # Actually draw a proper small down arrow
            ax = tx + ARR_X + 4
            top_a = ty + ARR_H * 0.55
            bot_a = ty + 1
            c.setStrokeColor(C_ARROW)
            c.setLineWidth(1.3)
            c.line(ax, top_a, ax, bot_a + 3)
            p = c.beginPath()
            p.moveTo(ax,     bot_a)
            p.lineTo(ax - 4, bot_a + 7)
            p.lineTo(ax + 4, bot_a + 7)
            p.close()
            c.drawPath(p, fill=1, stroke=0)

    cur_y -= flow_h + 8*mm

    # ── Anaesthetic Implications ──────────────────────────────────────────────
    # Title outside box
    c.setFillColor(C_ATITLE)
    c.setFont(FONT_HB, 11)
    c.drawString(ML, cur_y, "ANAESTHETIC IMPLICATIONS")
    cur_y -= 6*mm

    # Build rows
    a_rows = []
    for pt in anaesthetic_lines:
        for ln in wrap(pt, 56):
            a_rows.append(ln)

    abox_h = PAD_V + len(a_rows) * LH + PAD_V

    c.setFillColor(C_ABOX)
    c.roundRect(ML, cur_y - abox_h, BW, abox_h, 6, fill=1, stroke=0)

    ty = cur_y - PAD_V
    for ln in a_rows:
        ty -= LH
        c.setFillColor(C_TEXT)
        c.setFont(FONT, FS)
        c.drawString(tx, ty + 2, ln)

    # ── Footer ────────────────────────────────────────────────────────────────
    c.setFillColor(C_FREQ)
    c.setFont("Helvetica", 7.5)
    c.drawString(ML, 8*mm, f"Topic {topic_num} of 90  |  DNB Anaesthesiology Pathophysiology  |  2021-2025")
    c.drawRightString(MR, 8*mm, "Exam Revision")


# ── SAMPLE: Topic 15 -- Malignant Hyperthermia ───────────────────────────────
path = "/home/daytona/workspace/dnb-pathophysiology/SAMPLE_v7_Topic15_MH.pdf"
c = canvas.Canvas(path, pagesize=A4)

draw_page(
    c,
    topic_num   = 15,
    topic_title = "Malignant Hyperthermia",
    freq        = "High Priority (3x)  |  Dec 2022, Dec 2025, Oct 2023",
    flow_steps  = [
        "RYR1 gene mutation (chr 19q13) -- Autosomal Dominant",
        "Volatile agent (halothane > sevo > iso > des) OR succinylcholine",
        "RYR1 channel opens uncontrollably",
        "Massive Ca2+ floods sarcoplasm from sarcoplasmic reticulum",
        "Sustained muscle contraction + extreme ATP consumption",
        "Anaerobic glycolysis --> lactic acidosis + heat generation",
        "EtCO2 rises sharply (EARLIEST sign) + masseter spasm",
        "Tachycardia + hypertension + generalised muscle rigidity",
        "Hyperthermia (~1 deg C per 5 min) -- LATE sign",
        "Hyperkalaemia + severe metabolic acidosis",
        "Rhabdomyolysis --> myoglobinuria --> AKI + arrhythmias",
    ],
    anaesthetic_lines = [
        "STOP trigger agent + sux immediately. Call for help.",
        "Hyperventilate 100% O2 at 2-3x minute volume.",
        "DANTROLENE 2.5 mg/kg IV q5 min, max 10 mg/kg (blocks RYR1).",
        "Active cooling: ice packs + cold IV saline, target 38.5 deg C.",
        "Treat K+: calcium gluconate + insulin-glucose + NaHCO3.",
        "Use TIVA (propofol + remifentanil) -- avoid all volatiles.",
        "Stock min 36 vials dantrolene. Screen family (MHAUS).",
    ]
)

c.save()
print("Saved:", path)

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.units import mm
from reportlab.pdfgen import canvas

W, H = A4

def wrap(text, max_chars=56):
    words = text.split()
    lines, cur = [], ""
    for w in words:
        if len(cur) + len(w) + 1 <= max_chars:
            cur = (cur + " " + w).strip()
        else:
            if cur: lines.append(cur)
            cur = w
    if cur: lines.append(cur)
    return lines

def draw_page(c, topic_num, topic_title, freq, flow_steps, anaesthetic_lines):
    C_TITLE  = colors.HexColor("#4B5563")
    C_BOX    = colors.HexColor("#E8ECF0")      # grey flow box
    C_ABOX   = colors.HexColor("#DBEAFE")      # light blue anaesthetic box
    C_ATITLE = colors.HexColor("#1E40AF")      # blue title for anaesthetic section
    C_TEXT   = colors.HexColor("#1C1C1E")
    C_ARROW  = colors.HexColor("#374151")
    C_FREQ   = colors.HexColor("#9CA3AF")

    FONT    = "Courier"
    FONT_HB = "Helvetica-Bold"
    FONT_H  = "Helvetica"

    FS    = 11.5
    LH    = 7.2*mm
    ARR_H = 6.8*mm
    PAD_V = 7*mm
    PAD_H = 7*mm
    ARR_INDENT = 42   # px from left inner edge -- matches reference

    ML = 14*mm
    MR = W - 14*mm
    BW = MR - ML

    c.setFillColor(colors.white)
    c.rect(0, 0, W, H, fill=1, stroke=0)

    cur_y = H - 14*mm

    # Title outside box
    c.setFillColor(C_TITLE)
    c.setFont(FONT_HB, 13)
    c.drawString(ML, cur_y, f"{topic_title.upper()} PATHOPHYSIOLOGY FLOWCHART")
    cur_y -= 5.5*mm

    # Topic number + freq
    c.setFillColor(C_FREQ)
    c.setFont(FONT_H, 8.5)
    c.drawString(ML, cur_y, f"Topic {topic_num} of 90   |   {freq}")
    cur_y -= 7*mm

    # Build flow rows
    rows = []
    for i, step in enumerate(flow_steps):
        for ln in wrap(step, 56):
            rows.append(("text", ln))
        if i < len(flow_steps) - 1:
            rows.append(("arrow",))

    flow_h = PAD_V + sum(LH if r[0]=="text" else ARR_H for r in rows) + PAD_V

    c.setFillColor(C_BOX)
    c.roundRect(ML, cur_y - flow_h, BW, flow_h, 6, fill=1, stroke=0)

    tx = ML + PAD_H
    ty = cur_y - PAD_V

    for (kind, *rest) in rows:
        if kind == "text":
            ty -= LH
            c.setFillColor(C_TEXT)
            c.setFont(FONT, FS)
            c.drawString(tx, ty + 2, rest[0])
        else:
            ty -= ARR_H
            ax = tx + ARR_INDENT
            top_a = ty + ARR_H * 0.72
            bot_a = ty + 1.5
            c.setStrokeColor(C_ARROW)
            c.setFillColor(C_ARROW)
            c.setLineWidth(1.3)
            c.line(ax, top_a, ax, bot_a + 4)
            p = c.beginPath()
            p.moveTo(ax, bot_a)
            p.lineTo(ax - 4, bot_a + 8)
            p.lineTo(ax + 4, bot_a + 8)
            p.close()
            c.drawPath(p, fill=1, stroke=0)

    cur_y -= flow_h + 8*mm

    # Anaesthetic Implications title (outside box, blue)
    c.setFillColor(C_ATITLE)
    c.setFont(FONT_HB, 11)
    c.drawString(ML, cur_y, "ANAESTHETIC IMPLICATIONS")
    cur_y -= 6*mm

    # Build anaesthetic rows
    a_rows = []
    for pt in anaesthetic_lines:
        for ln in wrap(pt, 56):
            a_rows.append(ln)

    abox_h = PAD_V + len(a_rows) * LH + PAD_V

    c.setFillColor(C_ABOX)
    c.roundRect(ML, cur_y - abox_h, BW, abox_h, 6, fill=1, stroke=0)

    ty = cur_y - PAD_V
    for ln in a_rows:
        ty -= LH
        c.setFillColor(C_TEXT)
        c.setFont(FONT, FS)
        c.drawString(tx, ty + 2, ln)

    # Footer
    c.setFillColor(C_FREQ)
    c.setFont(FONT_H, 7.5)
    c.drawString(ML, 8*mm, "DNB Anaesthesiology Pathophysiology Flowcharts  |  2021-2025 Question Bank")
    c.drawRightString(MR, 8*mm, "Exam Revision Only")