A simplified educational diagram titled "Complement Activation & Periodontal Disease" for a university immunology exam. Clean white background, clear labeled boxes and arrows, black text, minimal color coding. Layout (top to bottom, left to right): TOP LEFT - Three activation pathways in colored boxes stacked vertically: - Pink box: "Classical Pathway" with small text "Antigen-Antibody (IgG/IgM) + C1 complex" - Light blue box: "Lectin Pathway" with small text "MBL-MASP complexes bind mannose on microbes" - Light green box: "Alternative Pathway" with small text "Spontaneous C3 hydrolysis on microbial surfaces" All three boxes have arrows pointing RIGHT to a central large circle labeled "C3" (blue) FROM C3 - two arrows splitting: - Arrow going UP-LEFT labeled "C3a" (small fragment) - Arrow going DOWN labeled "C3b" (large fragment) C3b has a curved arrow back to C3 labeled "Self-Amplification Loop (Alternative pathway amplification)" C3b also points DOWN to a box labeled "Opsonization → Phagocytosis" From C3, an arrow goes RIGHT to a large circle "C5" FROM C5 - two arrows: - Arrow going UP labeled "C5a" - Arrow going DOWN labeled "C5b" C5b points RIGHT to a box: "C5b + C6 + C7 + C8 + C9 → Membrane Attack Complex (MAC) → Bacterial lysis" TOP RIGHT - A box labeled "Inflammatory Cell Activation" showing: C3a and C5a → bind C3aR / C5aR (G-protein coupled receptors) → Cross-talk with TLRs → Activation of neutrophils, macrophages, mast cells → Release of inflammatory mediators, degradative enzymes, ROS FAR RIGHT - A small box: "Dysbiotic microbiome → Periodontitis → Alveolar bone loss" Use simple sans-serif font, bold section headers, clear directional arrows, color code: blue for complement proteins, pink/red for inflammatory outcomes, green for pathways, yellow for effector functions. Add a simple legend at the bottom.