MOLECULAR CARCINOGENESIS ER+ & HER2- HER2+ ER- & HER2- Germline mutation BRCA 2 P1K3CA mutation Germline mutation TP53 HER2 amplification Germline mutation BRCA1 TP53 mutation Precursor Lesions: Flat Epithelial Atypia Atypical Ductal Hyperplasia Precursor Lesion: Atypical Apocrine Adenosis No precursor lesion identified DCIS DCIS DCIS Invasive Cancer HER2 enriched Invasive Cancer Basal Like Invasive Cancer Luminal make a flow chart
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Create a visual flowchart diagram (PDF or image) of this molecular carcinogenesis pathway
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