Provide a short flashcard topics of antifungal drugs

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Antifungal Drugs - Flashcard Topics

#	Topic	Key Content
1	Drug Classification	4 classes: Polyenes, Azoles, Allylamines, Others
2	Polyenes - Mechanism	Bind ergosterol → form pores → cell death
3	Amphotericin B - PK	IV formulations, t½ = 15 days, liposomal forms
4	Amphotericin B - Clinical Uses	Systemic Candida, Cryptococcus, Aspergillus, Mucor, Histoplasma, Blastomyces
5	Amphotericin B - Adverse Effects	Infusion reactions + renal damage (most significant), anemia
6	Resistance to Amphotericin B	Decreased/modified ergosterol target
7	Flucytosine (5-FC)	Converted to 5-FU → blocks DNA/RNA synthesis; used with Amph B
8	Azoles - Mechanism	Inhibit fungal CYP450 → block ergosterol synthesis
9	Ketoconazole	Oral imidazole; inhibits human steroid synthesis; hepatotoxic; now rarely used
10	Triazoles Comparison	Itraconazole vs Fluconazole vs Voriconazole
11	Echinocandins	Caspofungin; inhibit glucan synthesis (cell WALL target); IV only
12	Griseofulvin	Binds keratin; for Tinea/ringworm; largely replaced by newer drugs
13	Terbinafine (Lamisil)	Allylamine; inhibits squalene epoxidase; drug of choice for onychomycosis
14	Topical Antifungals	Nystatin, Miconazole, Clotrimazole, Naftifine, Undecylenic acid, Tolnaftate
15	Drugs of Choice - Quick Reference	Infection-to-drug matching table

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Antifungal Drugs Flashcards

Presentation · PPTX

Each slide shows the question on the left and the full answer on the right, with color-coded topic tags (Mechanism = green, Adverse Effects = red, Drug of Choice = red, Clinical Uses = yellow, etc.).

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