Cytokines health and disease ppt for pathology resident doctor
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Cytokines Health and Disease
Presentation · PPTX
What's inside (18 slides)
| # | Slide |
|---|---|
| 1 | Title — bold typographic cover, dark navy with blue accent bar |
| 2 | Learning Objectives |
| 3 | What Are Cytokines? — definition, 4 key properties (pleiotropic, redundant, synergistic, auto/para/endocrine) |
| 4 | Classification of Cytokine Families — TNF, ILs (with subfamilies), IFNs, CSFs + Chemokines |
| 5 | Receptors & Signaling Pathways — Class I/II, TNFR, IgSF, GPCRs; JAK-STAT, NF-κB, MAPK overview |
| 6 | Cytokines in Acute Inflammation — Robbins Table 3.7 (TNF, IL-1, IL-6, chemokines, IL-17) |
| 7 | Cytokines in Chronic Inflammation — IL-12, IFN-γ, IL-17, TGF-β, IL-10 with pathology pearls |
| 8 | Th1/Th2/Th17/Treg Cytokine Profiles — polarizing signals, master TFs, disease links |
| 9 | Cytokine Storm — sepsis, COVID-19, MAS/HLH, CAR-T toxicity |
| 10 | Cytokines in Autoimmune Disease — RA, SLE, IBD, psoriasis, MS with therapeutic targets |
| 11 | Cytokines in Cancer — dual role: tumor-promoting vs. immunosurveillance/therapy |
| 12 | TNF-α / IL-1β / IL-6 in Depth — source, receptor, pathway, key actions, disease per cytokine |
| 13 | Interferons & Chemokines — type I/II/III IFNs; CXC, CC, CX3C chemokines; HIV co-receptors |
| 14 | Anti-Cytokine & Cytokine Therapeutics — 8 agents in a color-coded table |
| 15 | JAK Inhibitors & Cytokine Lab Measurement — JAKi drugs + JAK2 V617F; ELISA, multiplex, clinical uses |
| 16 | Cytokines in Pathology Practice — granulomas, acute phase/AA amyloidosis, fibrosis, TME, HLH, IBD |
| 17 | Summary Table — 10 cytokines: role, disease, therapeutic strategy at a glance |
| 18 | Key Takeaways & Discussion |
Design: Dark navy background throughout, bright blue accent lines, color-coded cards per cytokine family, tabular layouts for quick review. All content sourced from Robbins & Cotran 10e, Henry's Laboratory Medicine 7e, Abbas Cellular & Molecular Immunology 10e, and Roitt's Essential Immunology 14e.
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