Here is a solid overview of IV therapy based on medical textbook sources:
Intravenous (IV) Therapy
What Is IV Therapy?
IV therapy is the administration of fluids, medications, electrolytes, blood products, or nutrients directly into a vein. It provides the fastest, most reliable route of drug delivery - bypassing the gastrointestinal tract entirely - and is used in both emergency and routine clinical settings.
Why It's Used
- Rapid restoration of circulating blood volume (e.g., shock, dehydration)
- Delivery of medications when oral route is not possible
- Correction of electrolyte and acid-base disturbances
- Nutritional support (total parenteral nutrition)
- Blood and blood product transfusion
Types of IV Fluids
1. Crystalloids
- 0.9% Normal Saline (NS) - isotonic; first-line for volume resuscitation
- Lactated Ringer's (LR) - balanced electrolyte solution; Na 130 mEq/L (avoid in hyponatremia)
- Dextrose solutions - for hypoglycemia and energy support
- D10W for neonates and infants
- D25W (2 mL/kg) for children
- D50W (1 mL/kg) for adults/older children
2. Colloids
- Albumin, plasma - used when crystalloids alone are insufficient
3. Blood Products
- Packed red blood cells, fresh frozen plasma, platelets
Phases of IV Fluid Therapy
Based on ROSEN's Emergency Medicine, IV therapy typically follows three phases:
| Phase | Goal | Duration |
|---|
| Emergency (Resuscitation) | Restore circulating volume rapidly | Minutes |
| Repletion | Reverse fluid/electrolyte deficits, replace ongoing losses | 24 hours |
| Early Refeeding | Restore nutritional and fluid homeostasis | Days |
Emergency Resuscitation - Key Points
- Give 20 mL/kg of isotonic crystalloid IV rapidly for shock
- Reassess every 5-15 minutes - look for: normalization of BP, improved mental status, decreased heart rate, improved capillary refill, urine output
- If >60 mL/kg given without improvement - investigate for cardiogenic shock, sepsis, hemorrhage, or adrenal insufficiency
- Use intraosseous (IO) route if IV access cannot be obtained
Electrolyte Management During IV Therapy
From Pye's Surgical Handicraft (acute pancreatitis as a model):
- Daily serum electrolytes must be monitored
- Sodium, potassium, chloride replaced to maintain normal levels
- Hypokalemia - treated with IV potassium chloride (only if urine output is adequate)
- Hypocalcemia - treated with IV calcium gluconate
- Metabolic acidosis can develop - monitor with acid-base studies
- Maintain a careful fluid balance chart, including insensible losses
Hypoglycemia Management via IV
| Age Group | Dextrose Solution | Dose |
|---|
| Neonates | D10W | ~5 mL/kg |
| 1 month - 25 kg | D25W | 2 mL/kg |
| >2 years / adults | D50W | 1 mL/kg |
Note: D50W and D25W carry risk of tissue necrosis if they extravasate through a peripheral IV. D10W is safe at all ages.
Common IV Access Sites
- Peripheral IV - forearm, antecubital fossa, hand veins (most common)
- Central venous catheter (CVC) - subclavian, internal jugular, femoral veins (for long-term use, vasopressors, concentrated solutions)
- Intraosseous (IO) - used in emergencies when IV access fails
- PICC line - peripherally inserted central catheter (long-term therapy)
Complications of IV Therapy
| Complication | Description |
|---|
| Infiltration | Fluid leaks into surrounding tissue |
| Extravasation | Vesicant drug leaks - can cause tissue necrosis |
| Phlebitis | Vein inflammation - pain, redness, swelling |
| Infection/Sepsis | Catheter-related bloodstream infection |
| Air embolism | Air enters circulation through IV line |
| Fluid overload | Too much fluid given too fast - risk of pulmonary edema |
| Electrolyte imbalance | Especially with prolonged IV therapy |
Monitoring During IV Therapy
- Vital signs (BP, HR, RR, SpO2)
- Urine output (target >0.5 mL/kg/hr in adults)
- Daily fluid balance
- Serum electrolytes (Na, K, Cl, Ca, Mg)
- Blood glucose (every 30-60 min if treating hypoglycemia)
- Central venous pressure (CVP) or pulmonary artery wedge pressure in critically ill patients
Sources: ROSEN's Emergency Medicine (Concepts and Clinical Practice), p. Block 30 | Pye's Surgical Handicraft 22nd Ed., p. Block 3
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