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ECG normal vs abnormal findings interpretation 2025

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Here is a comprehensive guide to ECG Normal vs. Abnormal Findings:

The Normal ECG — Waves, Intervals & Segments

Normal ECG waveform showing P, Q, R, S, T waves with PR interval, ST segment, and QT interval labeled
Fig. 4.17 — Normal ECG waveform (Lead II). — Costanzo Physiology, 7th Ed.
The ECG records potential differences on the body surface that reflect the sequence of cardiac depolarization and repolarization.

Normal Parameters

Heart Rate

Age GroupNormal Range
Adult60–100 bpm
NeonateUp to 220 bpm (sinus tachycardia)

Intervals & Segments

ComponentNormal ValueRepresents
P wave<120 ms, upright in II, negative in aVRAtrial depolarization
PR interval120–200 ms (adult)Atrial → AV node → His bundle conduction
QRS complex<120 msVentricular depolarization
ST segmentIsoelectric (flat)Plateau phase of ventricular action potential
T waveUpright in most leadsVentricular repolarization
QT interval<440–460 ms (corrected, QTc)Ventricular depolarization to end of repolarization

Key ECG Components Explained

P Wave

  • Normally positive in lead II, negative in aVR (sinus rhythm)
  • May be biphasic in V1 (small positive right atrial component, small negative left atrial component — both normal)
  • Abnormal: retrograde P waves (negative in II, positive in aVR) → ectopic atrial or junctional pacemaker

PR Interval

  • Normal: ~160 ms (range 120–200 ms)
  • Prolonged → AV nodal conduction delay (e.g., 1st-degree heart block)
  • Shortened → pre-excitation (e.g., WPW syndrome) or enhanced AV conduction

QRS Complex

  • Phase 1: Septal depolarization (left → right) → small r in V1, small q in V6
  • Phase 2: LV dominates → S wave in V1, tall R in V6
  • Widened (≥120 ms) → bundle branch block, ventricular pacing, hyperkalemia

ST Segment & T Wave

  • Normally isoelectric; corresponds to the action potential plateau
  • ST elevation → acute STEMI, pericarditis, Brugada pattern, early repolarization, LV aneurysm
  • ST depression → subendocardial ischemia, digoxin effect, strain pattern
  • T-wave inversion → ischemia, ventricular hypertrophy, bundle branch blocks (secondary), PE

Major Abnormal Findings

1. Bundle Branch Blocks

RBBB vs LBBB vs Normal ECG patterns in V1 and V6
Fig. 247-10 — Normal, RBBB, and LBBB patterns in V1 and V6. Note secondary T-wave inversions. — Harrison's Principles of Internal Medicine, 22nd Ed.
PatternQRSV1V6Clinical Significance
RBBB≥120 msrSR' ("rabbit ears")qRSCan be normal; also ASD, PE, ischemia
LBBB≥120 msWide QSTall broad ROften marker of serious heart disease (CAD, HTN, cardiomyopathy)

2. ST-Elevation — Differential Diagnosis

CausePattern
Acute MI (STEMI)Regional, with reciprocal depressions
Acute pericarditisDiffuse, saddle-shaped, PR depression
Brugada syndromeCoved/saddle in V1–V2 with RBBB-like morphology
Early repolarizationConcave upward, mostly inferior/lateral leads
LV aneurysmPersistent elevation after prior MI
HyperkalemiaPeaked T waves → wide QRS → sine wave
HypothermiaJ (Osborn) waves
Pulmonary embolismS1Q3T3 pattern, RBBB

3. QT Prolongation

  • QTc >440 ms (men) / >460 ms (women) = abnormal
  • Causes: drugs (antiarrhythmics, antipsychotics, antibiotics), hypokalemia, hypomagnesemia, congenital long QT syndrome
  • Risk: torsades de pointes → ventricular fibrillation

4. Axis Deviation

AxisDegreesSignificance
Normal−30° to +90°
Left axis deviation−30° to −90°LAFB, inferior MI, LVH, WPW
Right axis deviation+90° to +180°RVH, LPFB, lateral MI, PE, normal in children

5. Hypertrophy Patterns

  • LVH: Tall R in V5/V6 (>25 mm), deep S in V1; Sokolow-Lyon criterion: S(V1) + R(V5 or V6) ≥35 mm
  • RVH: Tall R in V1, right axis deviation, strain pattern in V1–V3

6. Ischemia & Infarction Sequence

StageECG Change
HyperacuteTall, peaked ("hyperacute") T waves
Acute STEMIST elevation, loss of R wave
EvolvingDeep Q waves develop, ST normalizes
Old infarctPersistent Q waves, T-wave inversion
Anterior STEMI: ST elevation in V1–V4, I, aVL; reciprocal depression in II, III, aVF
Inferior STEMI: ST elevation in II, III, aVF; reciprocal depression in I, aVL

Quick Reference: Normal Adult ECG Values

ParameterNormal Range
Heart rate60–100 bpm
PR interval120–200 ms
QRS duration<120 ms
QTc<440 ms (men), <460 ms (women)
QRS axis−30° to +90°
P wave axis0° to +75° (upright in I and II)

Sources: Harrison's Principles of Internal Medicine, 22nd Ed.; Costanzo Physiology, 7th Ed.; Tintinalli's Emergency Medicine
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