In suspected heart attack or acute coronary syndrome, plain, non-enteric-coated aspirin should be chewed or dispersed in water because this gets it absorbed faster than swallowing it whole.
Disprin is a dispersible aspirin formulation, so it is intended to be dissolved in water before drinking.
Aspirin tablets: chew if they are plain, non-enteric-coated tablets. Do not chew enteric-coated or sustained-release tablets unless a clinician specifically advises it.
A common emergency adult dose is 300 mg once, if there is no aspirin allergy, active bleeding, or prior medical advice against aspirin. The BNF guidance specifically states that for acute coronary syndromes, 300 mg may be chewed or dispersed in water.
For chest pressure/pain, breathlessness, sweating, or pain radiating to the arm/jaw, call emergency services immediately. Aspirin does not replace urgent assessment.
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