TB drug hrze according to weight
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TB HRZE weight band dosing chart WHO 2026 isoniazid rifampicin pyrazinamide ethambutol kg
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Here is the complete HRZE weight-based dosing for TB, combining WHO guidelines and current sources:
HRZE Dosing by Weight Band (Adults)
Standard Daily Doses (mg/kg)
| Drug | Daily Dose (mg/kg) | Max Dose |
|---|---|---|
| H - Isoniazid | 4-6 mg/kg | 300 mg |
| R - Rifampicin | 8-12 mg/kg | 600 mg |
| Z - Pyrazinamide | 20-30 mg/kg | 2000 mg |
| E - Ethambutol | 15-25 mg/kg | 1200 mg |
Weight Band Dosing Table (WHO - Adults)
| Drug | 30-35 kg | 36-45 kg | 46-55 kg | 56-70 kg | >70 kg |
|---|---|---|---|---|---|
| H (Isoniazid) | 150 mg | 200 mg | 300 mg | 300 mg | 300 mg |
| R (Rifampicin) | 300 mg | 450 mg | 450 mg | 600 mg | 600 mg |
| Z (Pyrazinamide) | 800 mg | 1000 mg | 1200 mg | 1600 mg | 2000 mg |
| E (Ethambutol) | 600 mg | 800 mg | 1000 mg | 1200 mg | 1200 mg |
Indian NTEP Weight Band (Adults) - from National DR-TB Guidelines
| Drug | 16-29 kg | 30-45 kg | 46-70 kg | >70 kg |
|---|---|---|---|---|
| R (Rifampicin) | 300 mg | 450 mg | 600 mg | 750 mg |
| E (Ethambutol) | 400 mg | 800 mg | 1200 mg | 1600 mg |
| Z (Pyrazinamide) | 750 mg | 1250 mg | 1750 mg | 2000 mg |
Pediatric Weight-Band Dosing
| Drug | Dose (mg/kg/day) | Max |
|---|---|---|
| H (Isoniazid) | 10-15 mg/kg | 300 mg |
| R (Rifampicin) | 15-20 mg/kg (standard); 20-30 mg/kg (high-dose for infants/severe disease) | 600 mg |
| Z (Pyrazinamide) | 30-40 mg/kg | 2000 mg |
| E (Ethambutol) | 15-25 mg/kg | 1200 mg |
For pediatric weight bands (standard Rifampicin):
| Weight (kg) | Isoniazid | Rifampicin | Pyrazinamide | Ethambutol |
|---|---|---|---|---|
| 3-5 | 50 mg | 75 mg | 125 mg | 100 mg |
| 5.1-7.5 | 75 mg | 150 mg | 187.5 mg | 150 mg |
| 7.6-10 | 100 mg | 225 mg | 250 mg | 200 mg |
| 10.1-15 | 150 mg | 300 mg | 375 mg | 300 mg |
| 15.1-20 | 200 mg | 450 mg | 500 mg | 400 mg |
| >20 | 300 mg | 600 mg | See adult | See adult |
Key Notes
- H + Pyridoxine (Vitamin B6): Always co-prescribe pyridoxine 25-50 mg/day with Isoniazid to prevent peripheral neuropathy (especially in malnourished, pregnant, diabetic, HIV+ patients)
- E (Ethambutol): Monitor visual acuity and color vision; avoid in young children who cannot report visual changes
- R (Rifampicin): Strong enzyme inducer - orange discoloration of body fluids, multiple drug interactions (especially with HIV ARVs)
- Z (Pyrazinamide): Monitor uric acid and liver enzymes; causes hyperuricemia and hepatotoxicity
- Standard regimen: 2HRZE (intensive phase, 2 months) + 4HR (continuation phase, 4 months) = 6 months total
- Pyridoxine (Vitamin B6) dose by weight (India): 50 mg for 16-29 kg; 100 mg for >30 kg
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