DOTT notes
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DOTT notes "drug of the time" medical pharmacology format exam
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That's a full set of DOTT notes for NSAIDs. Here's a quick orientation to the format used:
- D - Drug name, chemical classification, and individual agents
- O - Other info: mechanism of action (COX-1 vs COX-2), pharmacokinetics, half-lives, protein binding
- T (first) - Toxicity and adverse effects, organ by organ
- T (second) - Therapeutic uses, indications, contraindications, and drug interactions
The 14 high-yield exam points at the bottom are the most commonly tested facts. A few that catch students out most often:
- Aspirin's irreversible COX inhibition (unique among NSAIDs)
- Coxibs reduce GI risk but NOT renal risk
- The prothrombotic mechanism of coxibs (↓ PGI2 without ↓ TXA2)
- Indomethacin for gout/AS/PDA, but tolmetin fails in gout
- Ibuprofen blocking aspirin's antiplatelet effect if given first
Let me know if you want this expanded for any specific NSAID, or if you need DOTT notes for another drug class.
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