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Gross Anatomy of the Breast & Axillary Lymph Nodes - MS1 Level
PART 1: GROSS ANATOMY OF THE BREAST
Position & Extent
The breast lies between the skin and the superficial pectoral fascia, overlying the pectoralis major muscle. Its base spans:
- Vertically: Rib 2 to Rib 6
- Horizontally: Sternum to mid-axillary line
- It also overlies the serratus anterior and external oblique muscles laterally
Mnemonic for borders: "2 to 6, Sternum to Side"
The Axillary Tail (of Spence)
A tongue of breast tissue wraps around the lower margin of pectoralis major and enters the axilla. This is the axillary tail (process) of Spence. It is clinically important - cancer can arise here and be mistaken for an axillary mass.
Breast Cross-Section - Complete Diagram
Structural Layers (Surface to Deep)
Think: "Skin - Fat - Gland - Fat - Fascia - Muscle"
| Layer | Contents |
|---|
| Skin | Nipple-areolar complex (NAC) |
| Subcutaneous fat | Surrounds glandular tissue |
| Glandular parenchyma | Lobes, ducts, TDLU |
| Retromammary fat | Behind the breast, before fascia |
| Superficial pectoral fascia | Deep boundary of breast |
| Pectoralis major muscle | The "floor" |
Three Tissue Components
Mnemonic: "GFA" - Gland, Fat, Architecture
- Glandular epithelium - the secretory machinery
- Adipose tissue - dominant in postmenopausal women
- Fibrous stroma - connective tissue scaffold
The Duct System (like an inverted tree)
Nipple (15-20 openings)
↑
Lactiferous sinuses (ampullae - dilated just below NAC)
↑
Lactiferous ducts (major ducts, 15-20 total)
↑
Segmental ducts → Subsegmental ducts
↑
Terminal ductules → Acini
= TDLU (Terminal Duct Lobular Unit)
Key fact: There are 15-20 lobes, each with its own lactiferous duct opening at the nipple. The TDLU is where most breast cancers originate.
Cooper's Ligaments (Suspensory Ligaments)
- Fibrous bands running from the chest wall (deep fascia) to the dermis
- Give the breast its shape and support
- When infiltrated by cancer, they shorten and pucker the skin
- This causes skin dimpling and the classic "peau d'orange" (orange peel) appearance
Memory hook: Cooper's ligaments = the "tent pegs" of the breast. When cancer pulls on them, the tent surface dimples.
Blood Supply
Mnemonic: "ILI" - Internal thoracic, Lateral thoracic, Intercostals
| Source | Branch | Region supplied |
|---|
| Internal thoracic artery | Medial mammary perforators (2nd-4th intercostal spaces) | Medial breast (major supply) |
| Lateral thoracic artery | Lateral mammary branches | Lateral breast |
| Intercostal arteries (2nd-5th) | Mammary branches | Various quadrants |
The internal thoracic artery (via perforators) is the dominant supply - this is why medial breast tumors can spread to internal mammary nodes.
Nerve Supply
Sensory innervation from intercostal nerves T2-T6 (lateral + medial mammary branches) and supraclavicular nerves (cervical plexus) to the upper breast.
High yield: The T4 intercostal nerve provides sensation to the nipple. Injury during breast surgery can cause nipple anesthesia.
PART 2: AXILLARY LYMPH NODES
Lymphatic Drainage of the Breast - Overview
~75-97% of breast lymph drains to axillary nodes. The rest goes to internal mammary (parasternal) nodes.
The Three Levels of Axillary Nodes
The landmark for all three levels is the pectoralis minor muscle:
Mnemonic: "LAM" - Lateral, Along, Medial (relative to pectoralis minor)
| Level | Position relative to pec minor | Nodes included | Drainage |
|---|
| Level I (lower) | Lateral to pec minor | Pectoral (anterior), Subscapular (posterior), Humeral (lateral), Paramammary | First station - primary drainage |
| Level II (middle) | Along pec minor | Central axillary, Interpectoral (Rotter's nodes) | Second station |
| Level III (upper) | Medial to pec minor (infraclavicular) | Apical axillary nodes | Final axillary station |
Complete Axillary Node Map (with all named groups)
Named Groups - Easy Memory System
"PSHCIA" for Level I (Pectoral, Subscapular, Humeral, Central gets divided here too, Interpectoral, Apical):
More simply:
| Group | Location | Drains |
|---|
| Pectoral (anterior) | Along medial wall of axilla / lateral chest | Anterior breast |
| Subscapular (posterior) | Along posterior axillary wall | Back, posterior shoulder |
| Humeral (lateral) | Along medial side of humerus / axillary vein | Upper limb |
| Central | Fat of axilla, behind pec minor | All Level I groups drain here |
| Interpectoral (Rotter's) | Between pec major and minor | Deep breast, goes straight to Level II |
| Apical | Above/medial to pec minor | All axillary nodes drain here |
Drainage Pathway
Breast → Level I → Level II → Level III (Apical)
↓
Subclavian lymphatic trunk
↓
Right lymphatic duct (right side)
Thoracic duct (left side)
↓
Junction of subclavian + internal jugular veins
Rotter's Nodes (Interpectoral nodes) - Exam Favorite
- Located between pectoralis major and pectoralis minor
- Part of Level II
- Can be bypassed by cancer skipping Level I entirely ("skip metastases")
- Surgically important: must be removed in modified radical mastectomy
Other Lymphatic Drainage Routes (Minor Pathways)
| Route | Destination | When important |
|---|
| Internal mammary (parasternal) nodes | Along internal thoracic vessels | Medial breast quadrant tumors |
| Supraclavicular nodes | Above clavicle | Advanced disease (N3 in staging) |
| Cross-drainage | Contralateral breast | Rare, explains contralateral spread |
| Subdiaphragmatic | Abdominal nodes | Inferior breast, very rare |
Important Nerves at Risk During Axillary Surgery
| Nerve | Muscle innervated | Injury consequence |
|---|
| Long thoracic nerve (C5,6,7) | Serratus anterior | Winged scapula |
| Thoracodorsal nerve | Latissimus dorsi | Weak arm adduction/extension |
| Medial pectoral nerve | Pectoralis major (and minor) | Pectoral wasting |
| Intercostobrachial nerve | Sensory - medial upper arm | Numbness/pain of inner upper arm |
Mnemonic: Nerves to protect = "Long Thoraco-Medial Intercostal" = LTMI - "Let The Muscle live, Intercostal too"
Clinical High-Yield Summary
| Concept | Key point |
|---|
| Sentinel node | First node(s) in lymphatic chain; usually in pectoral/external mammary group (Level I) |
| Skip metastases | Tumor bypasses Level I, goes directly to Level II or III; seen in ~5% |
| Peau d'orange | Cooper's ligament infiltration + dermal lymphatic obstruction |
| Axillary tail of Spence | Breast tissue in axilla; can be mistaken for axillary lymphadenopathy |
| Levels = surgical staging | Level I dissection standard; Level III = radical mastectomy territory |
Sources: Sabiston Textbook of Surgery; Gray's Anatomy for Students; General Anatomy and Musculoskeletal System (Thieme Atlas); Imaging Anatomy, Vol. 3