mkdir -p /tmp/workspace/pathology-pdf && python3 << 'PYEOF' from reportlab.lib.pagesizes import A4 from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle from reportlab.lib.units import cm from reportlab.lib import colors from reportlab.platypus import SimpleDocTemplate, Paragraph, Spacer, HRFlowable from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_JUSTIFY doc = SimpleDocTemplate( "/tmp/workspace/pathology-pdf/General_Pathology_Microbiology_Syllabus.pdf", pagesize=A4, rightMargin=2*cm, leftMargin=2*cm, topMargin=2*cm, bottomMargin=2*cm ) styles = getSampleStyleSheet() # Custom styles title_style = ParagraphStyle('Title', parent=styles['Normal'], fontSize=14, fontName='Helvetica-Bold', alignment=TA_CENTER, textColor=colors.HexColor('#1a237e'), spaceAfter=6) subtitle_style = ParagraphStyle('Subtitle', parent=styles['Normal'], fontSize=11, fontName='Helvetica-Bold', alignment=TA_CENTER, textColor=colors.HexColor('#283593'), spaceAfter=12) part_style = ParagraphStyle('Part', parent=styles['Normal'], fontSize=12, fontName='Helvetica-Bold', alignment=TA_CENTER, textColor=colors.white, backColor=colors.HexColor('#1565c0'), spaceBefore=12, spaceAfter=8, borderPadding=(4, 6, 4, 6)) section_style = ParagraphStyle('Section', parent=styles['Normal'], fontSize=11, fontName='Helvetica-Bold', textColor=colors.HexColor('#1565c0'), spaceBefore=10, spaceAfter=4, borderPadding=(2,0,2,0)) topic_style = ParagraphStyle('Topic', parent=styles['Normal'], fontSize=10, fontName='Helvetica-Bold', textColor=colors.HexColor('#2e7d32'), spaceBefore=6, spaceAfter=2) body_style = ParagraphStyle('Body', parent=styles['Normal'], fontSize=9, fontName='Helvetica', textColor=colors.HexColor('#212121'), spaceBefore=1, spaceAfter=1, leftIndent=12, leading=14) blueprint_section_style = ParagraphStyle('BpSection', parent=styles['Normal'], fontSize=10, fontName='Helvetica-Bold', textColor=colors.HexColor('#4a148c'), spaceBefore=6, spaceAfter=2) blueprint_body_style = ParagraphStyle('BpBody', parent=styles['Normal'], fontSize=9, fontName='Helvetica', leftIndent=12, leading=14) story = [] # Title story.append(Paragraph("GENERAL PATHOLOGY &amp; MICROBIOLOGY", title_style)) story.append(Paragraph("TOPIC-WISE SYLLABUS &amp; MARK WEIGHTAGE", title_style)) story.append(Spacer(1, 0.3*cm)) story.append(HRFlowable(width="100%", thickness=2, color=colors.HexColor('#1a237e'))) story.append(Spacer(1, 0.3*cm)) # PART I story.append(Paragraph("PART I: PATHOLOGY (Total: 50 Marks)", part_style)) # 1. Cell Injury story.append(Paragraph("1. Cell Injury, Adaptation, and Accumulations", section_style)) story.append(Paragraph("Typical Weight: 8-10 Marks", ParagraphStyle('wt', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("Necrosis &amp; Apoptosis:", topic_style)) items = [ "Define necrosis. Enumerate types of necrosis. Describe coagulative and caseous necrosis in detail.", "Describe gross, microscopic appearance, and mechanism of fat necrosis.", "Differences between dry and wet gangrene.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Calcification:", topic_style)) items = [ "Write on Pathologic calcification.", "Differentiate between dystrophic and metastatic calcification.", "Enumerate examples of dystrophic calcification.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Amyloidosis:", topic_style)) items = [ "Define and classify amyloidosis. Chemical nature of primary amyloidosis.", "Define secondary amyloidosis and name the organs affected.", "Mention different staining methods to demonstrate amyloid.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Adaptations &amp; Reversible Injury:", topic_style)) items = [ "Define Hypertrophy and give 2 examples. What is atrophy? Give four causes of atrophy.", "Define metaplasia and dysplasia, and give 2 examples of metaplasia.", "Describe the gross and microscopy of fatty liver and enumerate 3 causes.", "Describe pathogenesis of irreversible cell injury and add a note on free radical injury.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # 2. Inflammation story.append(Paragraph("2. Inflammation, Healing, and Repair", section_style)) story.append(Paragraph("Typical Weight: 10-12 Marks", ParagraphStyle('wt2', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("Acute &amp; Chronic Inflammation:", topic_style)) items = [ "Define acute inflammation. Describe vascular and cellular events of acute inflammation.", "Enumerate causative agents of inflammation.", "Enumerate the mechanisms and causes of increased vascular permeability.", "Describe formation of exudate.", "Mention different chemical mediators in acute inflammation and describe their functions.", "Describe in detail phagocytosis and chemotaxis.", "Give four examples of Granulomatous inflammation.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Healing &amp; Repair:", topic_style)) items = [ "Define repair and regeneration. Describe wound healing by secondary intention.", "Enumerate factors delaying wound healing and complications of wound healing.", "Describe gross and microscopy of granulation tissue.", "Describe healing of a fractured bone.", "Mention different types of cells in human body and comment on their regeneration.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # 3. Hemodynamics story.append(Paragraph("3. Hemodynamics and Shock", section_style)) story.append(Paragraph("Typical Weight: 8-10 Marks", ParagraphStyle('wt3', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("Oedema:", topic_style)) items = [ "Define oedema and discuss its etiopathogenesis. Enumerate pathogenetic mechanisms of generalised oedema.", "Describe pathogenesis and microscopy of pulmonary oedema.", "Describe pathogenesis of cardiac oedema.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Thrombosis:", topic_style)) items = [ "Define thrombosis and describe its etiopathogenesis.", "Discuss pathophysiology, morphology, clinical effects, and fate of a thrombus.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Embolism &amp; Infarction:", topic_style)) items = [ "Define and classify Embolism. Write a note on pulmonary embolism and fat embolism.", "Definition and types of infarcts with examples.", "Describe gross and microscopic appearance of different types of infarcts.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Congestion &amp; Shock:", topic_style)) items = [ "Pathogenesis and features of chronic venous congestion of the liver and lung.", "Classification and stages of shock.", "Define Septicaemia.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # 4. Neoplasia story.append(Paragraph("4. Neoplasia", section_style)) story.append(Paragraph("Typical Weight: 10-12 Marks", ParagraphStyle('wt4', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("General Neoplasia:", topic_style)) items = [ "Define neoplasia. Describe the differences between benign and malignant tumours.", "Describe the morphological characteristics of malignant tumours.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Metastasis:", topic_style)) items = [ "Enumerate the routes of metastasis.", "Describe routes and mechanisms of metastasis.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Carcinogenesis:", topic_style)) items = [ "Classify chemical carcinogens and write in detail about chemical carcinogenesis.", "Write in short about radiation carcinogenesis.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Clinical Aspects:", topic_style)) items = [ "Enumerate premalignant conditions of the oral mucosa and their significance.", "Give 3 examples of premalignant conditions in different organs.", "Enumerate paraneoplastic syndromes.", "Describe methods of laboratory diagnosis of malignant tumors (including exfoliative cytology).", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Specific Tumours:", topic_style)) items = [ "Describe gross and microscopic appearance of Squamous cell carcinoma.", "Ameloblastoma.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # 5. Systemic Pathology story.append(Paragraph("5. Systemic and Clinical Pathology", section_style)) story.append(Paragraph("Typical Weight: 8-10 Marks", ParagraphStyle('wt5', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("Cardiovascular &amp; Respiratory:", topic_style)) items = [ "Risk factors and pathogenesis of atherosclerosis. Enumerate complications in an atheromatous plaque.", "Enumerate 2 clinical features, 2 complications, and laboratory investigations for myocardial infarction.", "Enumerate stages, complications, and gross morphology of lobar pneumonia.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Infectious (Pathology):", topic_style)) items = [ "Describe Primary and Secondary Pulmonary tuberculosis. What is Ghon's complex and its fate?", "Describe the evolution of tubercle and primary complex.", "Differences between tuberculoid and lepromatous leprosy. Describe lepra reactions.", "Mention different stages of syphilis and congenital syphilis.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Hematology:", topic_style)) items = [ "Enumerate the investigations done in a case of anemia. Describe morphological classification of anaemia.", "Causes, clinical features, and laboratory diagnosis of iron deficiency anemia and megaloblastic anemia.", "What are leukaemias? Classify them, and enumerate the tests/peripheral blood picture.", "Laboratory investigations in a case of bleeding disorders.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Metabolic &amp; Nutritional:", topic_style)) items = [ "Enumerate laboratory investigations and complications (acute and late) of Diabetes mellitus. Describe glucose tolerance test.", "Clinical features and aetiology of Vitamin D-deficiency (Rickets) and Vitamin C deficiency (Scurvy).", "Mention the classification and diagnosis of jaundice.", "Enumerate 2 causes each of hematuria and proteinuria.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Spacer(1, 0.4*cm)) story.append(HRFlowable(width="100%", thickness=2, color=colors.HexColor('#1a237e'))) story.append(Spacer(1, 0.2*cm)) # PART II story.append(Paragraph("PART II: MICROBIOLOGY (Total: 50 Marks)", part_style)) # 1. General Microbiology story.append(Paragraph("1. General Microbiology", section_style)) story.append(Paragraph("Typical Weight: 8-10 Marks", ParagraphStyle('wt6', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("Bacterial Structure:", topic_style)) items = [ "Define the morphology of a bacterial cell with a diagram.", "Write functions and methods for demonstration of cell wall, capsule, spore, and metachromatic granules.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Growth &amp; Cultivation:", topic_style)) items = [ "Define total and viable count. Describe phases of bacterial growth curve with diagram.", "Describe factors affecting microbial growth.", "Enumerate various methods of anaerobiosis.", "Define and give two examples of enriched media.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Genetics:", topic_style)) items = [ "What is mutation? What is transduction?", "Define plasmids and give their importance.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Sterilization &amp; Disinfection:", topic_style)) items = [ "Define sterilization, disinfection, and antisepsis.", "Describe methods of moist heat (autoclave) and dry heat (hot air oven) sterilization.", "Describe various types and uses of bacterial filters.", "Classify and write the mode of action of disinfectants.", "Describe biomedical waste management (generation, segregation, pretreatment, disposal).", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Infection &amp; Pathogenesis:", topic_style)) items = [ "Enumerate various sources and modes of transmission of infection.", "Enumerate bacterial virulence factors.", "Differentiate between exotoxins and endotoxins.", "Koch's postulates.", "Write the role of normal flora in oral cavity.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # 2. Immunology story.append(Paragraph("2. Immunology", section_style)) story.append(Paragraph("Typical Weight: 6-8 Marks", ParagraphStyle('wt7', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("Immunity:", topic_style)) items = [ "Define and classify immunity.", "Describe the mechanisms and factors affecting innate immunity.", "Describe passive immunity.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Antigen-Antibody &amp; Serology:", topic_style)) items = [ "Define Antigen and Antibody. Describe the structure and functions of immunoglobulins.", "Describe the principle and applications of precipitation reaction, agglutination reaction, and ELISA.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Hypersensitivity &amp; Autoimmunity:", topic_style)) items = [ "Classify and describe hypersensitivity reactions with suitable examples.", "Define autoimmunity and describe mechanisms and examples of autoimmune diseases.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # 3. Systemic Bacteriology story.append(Paragraph("3. Systemic Bacteriology", section_style)) story.append(Paragraph("Typical Weight: 12-15 Marks", ParagraphStyle('wt8', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("Gram-Positive Cocci:", topic_style)) items = [ "Enumerate pyogenic cocci.", "Describe morphology, culture, toxins, enzymes, pathogenesis, and lab diagnosis of Staphylococcus aureus.", "Enumerate non-suppurative complications of Streptococcus pyogenes.", "Write differences between Streptococcus viridans and Streptococcus pneumoniae.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Gram-Negative Cocci:", topic_style)) items = [ "Morphology, culture, and lab diagnosis of Neisseria meningitidis.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Mycobacteria:", topic_style)) items = [ "Describe morphology, culture, pathogenicity, lab diagnosis, and immunoprophylaxis of Mycobacterium tuberculosis.", "Describe morphology and pathogenicity of Mycobacterium leprae.", "Enumerate acid-fast bacilli.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Corynebacterium:", topic_style)) items = [ "Morphology, culture, biochemical reactions, toxins, pathogenicity, lab diagnosis, and immunoprophylaxis of Corynebacterium diphtheriae.", "Elek's gel precipitation test.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Anaerobes &amp; Spore-Bearers:", topic_style)) items = [ "Name pathogenic anaerobic bacteria.", "Morphology, toxins, enzymes, pathogenesis, and lab diagnosis of Clostridium tetani and Clostridium welchii (Gas gangrene).", "Nagler reaction.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Spirochetes:", topic_style)) items = [ "Enumerate Spirochetes.", "Describe morphology, pathogenicity, and lab diagnosis (including standard/treponemal tests) of Treponema pallidum.", "Write the principle and uses of dark ground microscope.", "Enumerate oral manifestations of syphilis.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Oral Microbiology:", topic_style)) items = [ "Enumerate cariogenic micro-organisms.", "Describe the pathogenesis and factors affecting dental caries.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # 4. Virology story.append(Paragraph("4. Virology", section_style)) story.append(Paragraph("Typical Weight: 8-10 Marks", ParagraphStyle('wt9', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("General Virology:", topic_style)) items = [ "Classify viruses with suitable examples (DNA and RNA viruses). Write differences between bacteria and viruses.", "Describe general properties, replication, and methods of cultivation of viruses.", "Enumerate the steps in replication of viruses.", "Describe the laboratory diagnosis of viral infections.", "Enumerate 4 viral vaccines.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Specific Viruses:", topic_style)) items = [ "Describe morphology, transmission, lab diagnosis, and prophylaxis of Hepatitis B virus.", "Classify viruses causing oro-facial lesions and describe their transmission and lesions.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # 5. Mycology story.append(Paragraph("5. Mycology", section_style)) story.append(Paragraph("Typical Weight: 4-6 Marks", ParagraphStyle('wt10', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("General &amp; Specific Mycology:", topic_style)) items = [ "Write the morphological classification of fungi with examples.", "Write four differences between bacteria and fungi.", "Mention four factors predisposing to opportunistic fungal infections.", "Name four fungi causing opportunistic fungal infections (e.g., Candida) and write lab diagnosis of oral candidiasis.", "Enumerate fungi causing superficial and deep mycosis.", "Enumerate agents causing mycetoma and discuss its lab diagnosis.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # 6. Parasitology story.append(Paragraph("6. Parasitology &amp; Zoonosis", section_style)) story.append(Paragraph("Typical Weight: 4-6 Marks", ParagraphStyle('wt11', parent=styles['Normal'], fontSize=9, fontName='Helvetica-Oblique', textColor=colors.HexColor('#e65100'), leftIndent=0, spaceAfter=4))) story.append(Paragraph("Protozoa:", topic_style)) items = [ "Enumerate two protozoa with their infective forms.", "Describe the developmental stages of Plasmodium species in human cycle (life cycle) and its lab diagnosis.", "Write infective form and mode of entry of Entamoeba histolytica.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("Helminths:", topic_style)) items = [ "Enumerate four helminthes with examples.", "Name of definitive and intermediate host in life cycle of Taenia solium.", "Write infective form and mode of entry of Ascaris lumbricoides.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) story.append(Paragraph("General Concepts:", topic_style)) items = [ "Define Zoonosis and give examples.", "Define definitive and intermediate hosts with examples.", ] for item in items: story.append(Paragraph(f"• {item}", body_style)) # Blueprint section story.append(Spacer(1, 0.4*cm)) story.append(HRFlowable(width="100%", thickness=2, color=colors.HexColor('#1a237e'))) story.append(Spacer(1, 0.2*cm)) story.append(Paragraph("UNIVERSITY QUESTION PAPER BLUEPRINT / MARK DISTRIBUTION STANDARD", ParagraphStyle('BpTitle', parent=styles['Normal'], fontSize=11, fontName='Helvetica-Bold', alignment=TA_CENTER, textColor=colors.HexColor('#4a148c'), spaceAfter=8))) bp_items = [ ("Long Essay Questions (LEQs):", "Usually 2 questions given, 1 to be answered. Worth 10-20 marks each."), ("Short Essay Questions (SEQs):", "Usually 4-5 questions given, 3 to be answered. Worth 5-10 marks each."), ("Short Answer Questions (SAQs / Brief Notes):", "Usually 6-8 questions given, 5 to be answered. Worth 2-3 marks each."), ] for label, desc in bp_items: story.append(Paragraph( f'<b>{label}</b> {desc}', ParagraphStyle('BpItem', parent=styles['Normal'], fontSize=10, fontName='Helvetica', leftIndent=10, spaceBefore=4, spaceAfter=4, leading=15) )) doc.build(story) print("PDF created successfully!") PYEOF