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Epistaxis (Nosebleed)
Epistaxis is a very common otolaryngologic complaint. It is rarely life-threatening, but can be distressing and, in a minority of cases, requires emergency management. It has a bimodal age distribution - peaks in children and in the elderly.
Anatomy
The nasal blood supply comes from three arterial territories with rich anastomoses:
| Artery | Origin | Area Supplied |
|---|
| Sphenopalatine artery | External carotid | Turbinates, posterior and inferior septum |
| Anterior and posterior ethmoidal arteries | Ophthalmic branch of internal carotid | Superior mucosa, medially and laterally |
| Superior labial branch of facial artery | External carotid | Anterior mucosal septum, anterior lateral mucosa |
Kiesselbach's plexus (Little's area) is the rich arterial anastomosis on the anteroinferior nasal septum - the most common bleeding site.
Classification
Anterior Epistaxis (90%)
- Arises from Kiesselbach's plexus
- Common in children and young adults
- Usually unilateral
- Typically self-limited
Posterior Epistaxis (10%)
- Originates from the posterior septum or turbinates
- More common in elderly patients with atherosclerosis or bleeding disorders
- More severe, harder to manage
- May require inpatient monitoring
Causes
Local Causes
- Nose picking (most common in children)
- Nasal trauma / blunt impact
- Upper respiratory infections (mucosal vasodilation)
- Nasal foreign bodies
- Nasal polyps
- Tumours (including juvenile angiofibroma in adolescent boys)
- Granulomatous disorders
- Environmental irritants, cocaine use
- Chronic use of nasal vasoconstrictors
Systemic Causes
- Hypertension (no proven causation, but associated with persistent bleeding)
- Anticoagulants - warfarin, rivaroxaban
- Antiplatelet agents - aspirin, clopidogrel
- Coagulopathies - haemophilia, von Willebrand disease
- Thrombocytopenia, leukaemia
- Hepatic disease / alcoholism
- Vitamin K or folic acid deficiency
- Hereditary Haemorrhagic Telangiectasia (HHT) / Osler-Weber-Rendu disease - recurrent multifocal bleeding from thin-walled vessels lacking muscle and elastic tissue
HHT (Osler's disease) with multiple facial telangiectasias - Bailey & Love's Surgery, 28th Ed.
Clinical Evaluation
History: Timing, frequency, severity; laterality; trauma; medications (anticoagulants, antiplatelets, NSAIDs); bleeding disorders; prior nasal surgery.
Examination:
- Assess airway, hemodynamics, and tissue perfusion first
- Have the patient blow the nose to expel clots, then apply firm bilateral pressure on the cartilaginous part of the nose (not the bony bridge) for 10-15 minutes
- Administer 0.05% oxymetazoline (2 sprays) into the affected naris before applying pressure
- Examine the floor of the nose with the head parallel to the floor (not tilted back)
Labs: Not routinely needed. Order coagulation studies (PT, PTT, INR) and CBC in patients on anticoagulants, severe haemorrhage, suspected liver disease, or haematologic malignancy.
Management
Step 1 - First Aid (all patients)
- Sit upright, lean slightly forward (prevents swallowing blood)
- Compress the cartilaginous nose firmly for 10-15 minutes without releasing
- Topical vasoconstrictor: oxymetazoline or xylometazoline spray
Step 2 - Anterior Epistaxis (if bleeding point identified)
Chemical cautery with a silver nitrate stick:
- Applied from periphery to centre, superior to inferior
- Contact no longer than 15 seconds to avoid septal necrosis
- Never apply bilaterally at the same session (risks septal necrosis)
Topical haemostatic agents: Absorbable gelatin sponge (Gelfoam), Surgicel - if cautery fails.
Topical tranexamic acid: Inhibits fibrinolysis. 500 mg of IV solution applied to a nasal pledget or atomized. Evidence shows it reduces bleeding at 10 minutes and re-bleeding at 7-10 days, particularly effective in patients on antiplatelet drugs. No significant increase in adverse events. - Rosen's Emergency Medicine, 10th Ed.
Step 3 - Anterior Nasal Packing (if above fails)
Options:
- Merocel (polyvinyl acetal nasal tampon) - inserted along the floor of the nose
- Rapid Rhino (inflatable nasal balloon) - procoagulant-coated, moistened before insertion, inflated with air
- Petroleum jelly (Vaseline)-impregnated ribbon gauze - packed posterior to anterior
A 2025 systematic review and meta-analysis (PMID 40546131) found no significant difference in efficacy between Merocel and Rapid Rhino devices.
Note: Routine prophylactic antibiotics with anterior nasal packing are NOT recommended.
Step 4 - Posterior Epistaxis
Suspect when bleeding persists despite proper anterior packing.
- Double balloon catheter device: Posterior balloon inflated first in nasopharynx, then pulled anteriorly and seated; anterior balloon then inflated
- Foley catheter alternative: Inserted into nasopharynx, inflated with 5-7 mL of water
- Requires inpatient monitoring (risk of airway compromise, hypoxia, vagal reactions)
- Elderly patients: nasal packing carries risk of pulmonary/cardiac complications
Step 5 - Refractory / Surgical Cases
For epistaxis not responding to packing:
| Procedure | Notes |
|---|
| Endoscopic sphenopalatine artery clipping | Effective for significant refractory epistaxis |
| Internal maxillary artery ligation | Via pterygopalatine fossa (endoscopic access) |
| Anterior/posterior ethmoidal artery ligation | For superior/ethmoidal bleeding |
| External carotid artery ligation | Last resort above the lingual artery |
| Endovascular embolization | Interventional radiology; success rates 91-97%, complication rate 0-3%; preferred over surgery in many centres for posterior bleeding |
Special Situations
Juvenile Angiofibroma: Affects adolescent boys. Highly vascular - do NOT biopsy. Diagnose with contrast CT or MRI (Holman-Miller sign: anterior bowing of the posterior antral wall). Managed with preoperative embolization followed by endoscopic excision.
HHT: Recurrent, multifocal bleeds. Standard packing is often inadequate. Laser photocoagulation, anti-angiogenic therapy (bevacizumab), or septal dermoplasty may be needed.
Paediatric epistaxis (<2 years): Rare - consider non-accidental trauma and bleeding disorders.
Anticoagulated patients: Topical tranexamic acid is particularly effective. Address anticoagulation reversal if appropriate.
When to Refer to ENT / Hospital Admission
- Posterior epistaxis
- Haemodynamic instability or large blood loss
- Failed anterior packing
- Suspected underlying vascular or haematologic disorder
- Juvenile angiofibroma or tumour suspected
Sources: Rosen's Emergency Medicine - Concepts and Clinical Practice, 10th Ed. | Bailey and Love's Short Practice of Surgery, 28th Ed. | Cummings Otolaryngology Head and Neck Surgery | Grainger & Allison's Diagnostic Radiology