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| Scenario | Details |
|---|---|
| Standard starting dose | 10–25 mg at night |
| Taking 3 × 10mg = 30mg | Within the therapeutic range for many uses |
| Maximum dose (outpatient) | 75–150 mg/day (divided or single night dose) |
⚠️ If someone has taken more than their prescribed dose — especially if they are drowsy, confused, have a rapid/irregular heartbeat, or are unresponsive — this is a medical emergency. Call emergency services immediately.
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☎️ Call Emergency Services RIGHT NOW
If you or someone else has taken this amount — call your local emergency number immediately (112 / 911 / 108). Do NOT wait for symptoms to appear. TCA overdose can kill within 1–2 hours.
| System | Effect |
|---|---|
| Heart | Deadly arrhythmias (ventricular tachycardia, ventricular fibrillation), QRS widening, heart block — can cause sudden cardiac arrest |
| Blood pressure | Severe hypotension (BP crash) |
| Brain | Seizures, coma, loss of consciousness |
| Breathing | Respiratory depression — breathing can stop |
| Anticholinergic crisis | Extreme agitation, high temperature, dilated pupils, dry flushing skin, urinary retention |
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| Timeline | What Happens |
|---|---|
| 0–30 min | Rapid sedation, confusion, dry mouth, blurred vision, racing heart |
| 30–90 min | Seizures, blood pressure crash, loss of consciousness |
| 1–3 hours | Ventricular arrhythmias (heart goes into chaotic rhythm), cardiac arrest |
| Without treatment | Coma and death |