Amoxyclav drops pediatric dosage
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Amoxicillin clavulanate pediatric drops dosage
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The retrieval didn't return direct dosage content. Here is a comprehensive answer based on established clinical knowledge:
Amoxyclav (Amoxicillin + Clavulanate) Pediatric Drops
Formulation
Amoxyclav Pediatric Drops typically contain:
- Amoxicillin 200 mg + Clavulanic acid 28.5 mg per 5 mL
(Some brands offer 125 mg/31.25 mg per 5 mL suspension — confirm the specific product formulation before dosing.)
Standard Dosing (by Amoxicillin component)
| Age/Weight | Dose | Frequency |
|---|---|---|
| Neonates & infants < 3 months | 30 mg/kg/day (amoxicillin) | Divided every 12 hours |
| Infants & children (mild–moderate infection) | 25–45 mg/kg/day | Divided every 12 hours |
| Severe infections | 40–90 mg/kg/day | Divided every 8–12 hours |
| Max dose | 3000 mg/day (amoxicillin component) | — |
Common Indications in Pediatrics
- Acute otitis media (AOM)
- Community-acquired pneumonia
- Sinusitis
- Skin and soft tissue infections
- Urinary tract infections
Acute Otitis Media (High-Dose Regimen)
For suspected Streptococcus pneumoniae (drug-resistant) or treatment failure:
- 80–90 mg/kg/day of amoxicillin component, divided every 12 hours
- Duration: 5–7 days (younger children or severe cases: 10 days)
Practical Dosing Guide (200 mg/5 mL drops)
| Weight (kg) | Dose (mg amoxicillin) | Volume (mL) twice daily |
|---|---|---|
| 3–5 kg | ~75–100 mg | ~2 mL BD |
| 6–8 kg | ~125–150 mg | ~3 mL BD |
| 9–12 kg | ~175–200 mg | ~4–5 mL BD |
| 13–15 kg | ~250 mg | ~6 mL BD |
(Adjust based on actual formulation and clinical severity)
Key Points
- Give with food to reduce GI side effects and enhance clavulanate absorption
- Shake well before use; store reconstituted suspension in the refrigerator (use within 7–10 days)
- The clavulanate component is the limiting factor for GI tolerability — higher frequency (TID) increases diarrhea risk; prefer BD dosing with the 7:1 or 14:1 formulation
- Avoid in penicillin allergy; use with caution in hepatic impairment (clavulanate is hepatotoxic in high doses)
- Jaundice/hepatitis has been reported — monitor in prolonged use
Note: Always calculate dose based on the child's actual body weight and confirm the exact mg/mL concentration of the specific brand before dispensing.
Paracetamol pediatric dosage
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paracetamol acetaminophen pediatric dosage children
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Paracetamol (Acetaminophen) Pediatric Dosage
Standard Dose
10–15 mg/kg/dose every 4–6 hours as needed
- Max doses per day: 5 doses in 24 hours
- Max daily dose: 75 mg/kg/day (not to exceed 4000 mg/day)
- Infants/children < 2 years: Max daily dose capped at 60 mg/kg/day
Route-Specific Dosing
| Route | Dose | Frequency |
|---|---|---|
| Oral | 10–15 mg/kg/dose | Every 4–6 hours |
| IV (< 50 kg) | 12.5 mg/kg every 4 h or 15 mg/kg every 6 h | Max single dose: 15 mg/kg (≤750 mg); Max daily: 75 mg/kg/day |
| Rectal (suppository) | 15–20 mg/kg/dose | Every 6–8 hours |
Weight-Based Quick Reference (Oral)
| Weight (kg) | Dose (mg) | Paracetamol 125 mg/5 mL syrup | Paracetamol 250 mg/5 mL syrup |
|---|---|---|---|
| 5 kg | 75 mg | 3 mL | 1.5 mL |
| 7 kg | 100 mg | 4 mL | 2 mL |
| 10 kg | 125–150 mg | 5–6 mL | 2.5–3 mL |
| 12 kg | 150–180 mg | 6–7 mL | 3–3.5 mL |
| 15 kg | 175–225 mg | 7–9 mL | 3.5–4.5 mL |
| 20 kg | 200–300 mg | 8–12 mL | 4–6 mL |
Common Formulations
| Formulation | Concentration |
|---|---|
| Drops (infant) | 100 mg/mL |
| Syrup | 125 mg/5 mL or 250 mg/5 mL |
| Suppository | 125 mg, 250 mg |
| IV infusion | 10 mg/mL |
Key Safety Points
- Never exceed 5 doses in 24 hours regardless of route
- Do not combine with other paracetamol-containing products (e.g., combination cold/flu syrups) — risk of inadvertent overdose
- Hepatotoxicity occurs with overdose; threshold is lower in malnourished children and those with liver disease
- For neonates, use with caution — limited data; typical dose is 10–15 mg/kg every 6–8 hours
- Fever management: Dose at 15 mg/kg is preferred for faster antipyresis; 10 mg/kg suffices for mild pain
(Source: Addressing Pain in People Living With Cystic Fibrosis, p. 8)
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