Code Trait Rewind-contextual meaning Pattern Flag RW-T01 Genomic instability tendency Genetic tendency for accumulating DNA-level errors over time, shaping how aggressively Rewind recommends DNA-protective lifestyle and surveillance levers. `per_allele_sum` — RW-T02 DNA repair capacity Genetic capacity of base-excision and nucleotide-excision repair pathways, used by Rewind to flag whether repair-supporting cofactors and exposure-reduction matter more for this person. `per_allele_sum` — RW-T03 Double-strand break repair tendency Genetic strength of homologous-recombination and NHEJ pathways, informing Rewind's view on tolerance for radiation/oxidative load and how cautiously to escalate hormetic stressors. `per_allele_sum` — RW-T04 Telomere maintenance tendency Polygenic tendency toward shorter or unstable telomere length, used by Rewind to weight cellular-aging pressure and prioritize sleep, stress, and inflammation levers. `prs_derived` — RW-T05 Cellular stress-response resilience Genetic robustness of heat-shock and integrated stress responses, informing how Rewind doses hormetic interventions like heat, cold, and fasting. `per_allele_sum` — Can you identify snps linked to each trait with literature reference both global and with special focus on south asian/Indian studies, evidence tier and flags if any.
genomic instability SNP polygenic cancer DNA damage South Asian
DNA repair capacity SNP BER NER polymorphism XRCC OGG1 ERCC
double strand break repair SNP BRCA1 BRCA2 XRCC3 RAD51 homologous recombination NHEJ
telomere length SNP polygenic score TERT TERC South Asian Indian
heat shock protein SNP HSP70 HSPA1 stress response polymorphism longevity
XRCC1 OGG1 polymorphism DNA repair cancer risk
RAD51 XRCC3 double strand break repair polymorphism cancer
telomere length GWAS TERT TERC SNP aging
HSPA1 HSF1 heat shock polymorphism aging stress
SNPs genomic instability DNA repair telomere length heat shock protein South Asian Indian population GWAS 2020 2025
XRCC1 OGG1 ERCC2 ERCC1 polymorphism South Asian Indian cancer DNA repair BER NER GWAS review 2018 2024
HSP70 HSPA1B HSPA1L HSF1 SNP longevity aging stress resilience Indian South Asian polymorphism
SNP polymorphism DNA repair telomere longevity South Asian Indian stress response
RAD51 G135C BRCA2 NBN NHEJ XRCC4 LIG4 polymorphism cancer India South Asian study 2015 2024
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RW-T01 (Genomic instability): 6 SNPs across TP53, MLH1, XPC, ERCC2. The TP53 rs1042522 (Pro72Arg) is the most clinically relevant for Indian populations — Arg72 MAF ~0.70 in Indians, with replicated cancer associations across oral, cervical, and lung cohorts.
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RW-T02 (BER/NER capacity): 7 SNPs, led by XRCC1 rs25487 (Arg399Gln) — the single most studied DNA repair SNP in Indian populations, with data from North and South India, though direction varies by tissue and co-exposures. The APEX1 rs1760944 M allele is notably protective in Asians and should be scored in the opposite direction.
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RW-T03 (DSB repair / HR + NHEJ): 7 SNPs; RAD51 rs1801320 (G135C) has direct South Indian validation (PLOS ONE 2022) and a Kashmir CRC study. The CC genotype confers the lowest homologous recombination capacity — a clear flag for escalating oxidative/radiation load cautiously.
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RW-T04 (Telomere maintenance): The most robustly characterised for South Asians. TERC rs12696304 is genome-wide significant in a 5,075-person Bangladeshi GWAS. RTEL1 rs2297439 is a novel SA-specific locus with MAF 3× higher than in Europeans — Rewind's PRS for this trait should prioritise SA-calibrated weights.
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RW-T05 (Stress resilience): Thinnest SA evidence. FOXO3A rs25651 is the best-anchored cross-ethnic longevity SNP with Indian enrichment data. HSP70 family variants (HSPA1A −110A>C, HSPA1B A1267G) have longevity associations in European and Chinese cohorts but no dedicated Indian replication yet — flag these as lower-confidence until IndiGen/PMBB data emerges.