Cytokyins health and disease ppt for pathology resident doctor
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Cytokines Health and Disease
Presentation · PPTX
What's Inside (22 Slides)
The deck uses a deep navy + sky-blue color scheme with coral/green accents to distinguish pro- vs. anti-inflammatory content. All content is sourced from Robbins & Kumar Basic Pathology and Henry's Clinical Diagnosis & Management by Laboratory Methods.
| # | Slide | Content |
|---|---|---|
| 1 | Title | |
| 2 | Learning Objectives | 6 resident-level objectives |
| Section 1 | Introduction | |
| 3 | What are Cytokines? | Definition, modes of action, pleiotropism/redundancy |
| 4 | Cytokine Families | Table: ILs, TNF, IFNs, CSFs, Chemokines, TGF-β, Adipokines |
| Section 2 | Signalling | |
| 5 | JAK-STAT Pathway | Steps, key cytokine-JAK-STAT associations, SOCS regulation |
| 6 | NF-κB & MAPK | Two-column cards comparing both pathways |
| Section 3 | Pro-inflammatory | |
| 7 | TNF-α | Sources, mechanisms, cachexia, anti-TNF therapy risks |
| 8 | IL-1β | Inflammasome activation, disease links, anakinra |
| 9 | IL-6 & IL-17 | Two-column: tocilizumab / secukinumab targets |
| 10 | Chemokines | Families, CXCL8, CCL2, CCR5 (HIV co-receptor) |
| Section 4 | Anti-inflammatory | |
| 11 | IL-10, TGF-β, IL-4/13 | Treg cytokines, fibrosis, dupilumab |
| Section 5 | Systemic reactions | |
| 12 | Acute-Phase Response | IL-6 driver, CRP, ESR, PCT, ferritin |
| 13 | Cytokine Storm / SIRS | Sepsis, HLH, CAR-T CRS, COVID-19; tocilizumab, emapalumab |
| Section 6 | Cytokines in disease | |
| 14 | Autoimmune diseases | Table: RA, SLE, psoriasis, IBD, MS, AS, Sjögren |
| 15 | Cancer biology | IL-6/STAT3, JAK2 V617F, TGF-β dual role, IFN-γ |
| 16 | Infectious disease | Type I IFN, Th1 defense, HIV co-receptors, H5N1 storm |
| 17 | Fibrosis & tissue repair | TGF-β master fibrosis cytokine, IPF therapy |
| Section 7 | Diagnostics & therapeutics | |
| 18 | Lab measurement | ELISA, multiplex/Luminex, IL-6, IL-18, PCT, sCD25 |
| 19 | Biologics table | 10 drugs: anti-TNF, anti-IL-6, JAK inhibitors, etc. |
| 20 | Summary schematic | Trigger → early → adaptive → resolution → dysregulation |
| 21 | 7 Take-home messages | Color-coded numbered cards |
| 22 | References | 7 authoritative citations |
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