book_title | section_heading | file_path | line_start | line_end | snippet -----------+-----------------+-----------+------------+----------+--------- Guyton and Hall Textbook of Medical Physiology | Resetting the Hypothalamic Temperature- | /textbooks/9780443111013/9780443111013_block9.md | 230 | 233 | ...Several experiments have suggested that IL-1 causes fever by first inducing formation of one of the prosta- glandins, mainly >>>prostaglandin<<< E2, or a similar substance, which acts in the >>>hypothalamus<<< to elicit the fever... Localization in Clinical Neurology, 8e | P YROGEN I NDUCED | /textbooks/9781975160241/9781975160241_block5.md | 2089 | 2093 | ...the >>>hypothalamus<<< and, in addition, induce the release of interleukin 1 (endogenous >>>pyrogen<<<) from leukocytes and macrophages [ 55 ] . Circulating interleukin 1 acts in the preoptic and paraventricular area of the anterior >>>hypothalamus<<<, inducing >>>prostaglandin<<< E2... Janeway's Immunobiology 10e | 3-21 Cytokines made by macrophages and dendritic cells induce a systemic reaction known as the acute-phase response. | /textbooks/9780393884876/9780393884876_block1.md | 2781 | 2781 | ...exogenous >>>pyrogen<<<. Endogenous pyrogens cause fever by inducing the synthesis of >>>prostaglandin<<< E2 by the enzyme cyclooxygenase-2, the expression of which is induced by these cytokines. >>>Prostaglandin<<< E2 then acts on the >>>hypothalamus<<<, resulting... Cellular and Molecular Immunology | Systemic and Pathologic Consequences of Inflammation | /textbooks/9780323757485/9780323757485_block1.md | 2656 | 2658 | ...TNF and IL-1 act on the >>>hypothalamus<<< to induce an increase in body temperature (fever). These cytokines are therefore called endogenous pyrogens (i.e., host-derived fever-causing agents, to distinguish them from LPS...