How to manage this case
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python3 -c " import pdfplumber files = [ '/tmp/workspace/attachments/7e98c105-4ed2-4073-b822-46e66d73506d/20 July latest mri report.pdf', '/tmp/workspace/attachments/7e98c105-4ed2-4073-b822-46e66d73506d/csf.pdf' ] for f in files: print(f'=== FILE: {f} ===') with pdfplumber.open(f) as pdf: for i, page in enumerate(pdf.pages): text = page.extract_text() print(f'--- Page {i+1} ---') print(text) print() "
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python3 -c " from pypdf import PdfReader import base64 # Try to extract images from PDFs for fname, label in [ ('/tmp/workspace/attachments/7e98c105-4ed2-4073-b822-46e66d73506d/20 July latest mri report.pdf', 'mri'), ('/tmp/workspace/attachments/7e98c105-4ed2-4073-b822-46e66d73506d/csf.pdf', 'csf') ]: reader = PdfReader(fname) print(f'=== {label}: {len(reader.pages)} pages ===') for i, page in enumerate(reader.pages): images = page.images print(f' Page {i+1}: {len(images)} images') for j, img in enumerate(images): out = f'/tmp/workspace/{label}_p{i+1}_img{j+1}.{img.name.split(\".\")[-1] if \".\" in img.name else \"png\"}' with open(out, 'wb') as f: f.write(img.data) print(f' Saved: {out} ({len(img.data)} bytes)') "
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cerebellar hemorrhage craniectomy VP shunt management
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"cerebellar hemorrhage"[MeSH Terms] AND "surgical treatment"[MeSH Terms]
I now have comprehensive data to provide a thorough clinical management plan. Let me compile the full answer based on all the reports reviewed.
Case Summary
Patient: Mr. Rajendra Anjankar, 59 years, Male
Referring physician: Dr. N. Jaiswal, Suretech Hospital, Nagpur
Documents Reviewed
MRI Brain (20 July 2026 - Follow-up study)
Impression - Post-op case of right cerebellar bleed:
| Finding | Detail |
|---|---|
| Post-operative status | Suboccipital craniectomy |
| Acute infarct | Small to medium, right peritrigonal region (DWI restriction, low ADC) |
| Lacunar infarcts | Few acute to subacute, bilateral fronto-parietal white matter |
| Cerebellar hemorrhage | Significant evacuation seen; residual hemorrhage 28×32 mm in operative bed |
| Intraventricular extension | Mild resolution (improving) |
| Ventricular system | Mild dilatation; VP shunt in situ |
| Ischemic foci | Multiple lacunar, bilateral ganglio-capsular + fronto-parietal white matter |
| White matter changes | Mild to moderate periventricular ischemic changes |
| Comparison to 16-Jul-2026 | No significant interval change |
CSF Reports (Dhruv Pathology Lab) - Three separate samples
Sample 1 - Collected 11/07/2026:
- Blood culture (aerobic + anaerobic): No growth after 5 days - Final report negative
Sample 2 - Collected 16/07/2026 (CSF - Reddish, Turbid):
- Gram stain: Few RBCs, few lymphocytes, few polymorphs; no organism seen
- AFB stain: Acid fast bacilli not seen
- Culture & Sensitivity (preliminary, 17/07/2026): No growth after overnight incubation - awaiting final
Sample 3 - Collected 21/07/2026 (CSF - Colourless, Clear):
- Gram stain: Pus cells not seen, organism not seen
- AFB stain: Acid fast bacilli not seen
- Culture & Sensitivity (preliminary, 22/07/2026): No growth after overnight incubation - awaiting final
Clinical Interpretation
This is a complex post-operative neurosurgical case with several concurrent issues:
1. Residual Cerebellar Hemorrhage (28×32 mm)
- The hematoma has been significantly evacuated surgically, but a sizeable residual remains in the operative bed
- No interval change from 16-Jul to 20-Jul suggests stabilization - this residual clot is likely organizing/resolving naturally
- Management: Conservative - serial MRI monitoring every 2-4 weeks. Re-evacuation is not indicated unless neurological deterioration occurs. Avoid anticoagulants and antiplatelet agents for now.
2. New Acute Infarct - Right Peritrigonal Region
- DWI restriction with low ADC confirms true acute ischemic infarct (not T2 shine-through)
- Mechanism likely: post-operative hypoperfusion, vasospasm near operative site, or micro-emboli
- The timing (post suboccipital craniectomy) puts this in the posterior circulation territory
- Management:
- Aspirin 75-100 mg/day (once hemorrhage stabilizes - after discussion with neurosurgeon, typically safe 2-4 weeks post-op when residual hematoma is stable)
- Strict blood pressure control - aim for systolic 130-140 mmHg (avoid hypotension which worsens ischemia, avoid hypertension which risks re-bleed)
- Statin therapy: Atorvastatin 40 mg nightly (pleiotropic + lipid-lowering benefit post-stroke)
- Rule out atrial fibrillation with ECG/Holter monitoring
- Evaluate for underlying vasculopathy (lipid profile, HbA1c, fasting glucose)
3. Multiple Lacunar Infarcts (bilateral ganglio-capsular, fronto-parietal)
- Pattern suggests small vessel disease (lacunar vasculopathy)
- Contributing factors at 59 years: hypertension, diabetes, smoking - all need aggressive secondary prevention
- Management:
- Control vascular risk factors aggressively (target BP <130/80 mmHg, HbA1c <7%, LDL <70 mg/dL)
- Aspirin + statin (as above)
- Long-term rehabilitation (physiotherapy, speech therapy if affected)
4. VP Shunt In Situ - Mild Ventricular Dilatation
- Shunt is functioning (mild dilatation only, down from the presumed worse state earlier given the intraventricular hemorrhage)
- Mild resolution of intraventricular extension is reassuring
- Management:
- Monitor for shunt malfunction: symptoms include worsening headache, drowsiness, vomiting, deteriorating GCS
- Serial CT head at intervals to monitor ventricular size
- Shunt revision if ventricular size increases or symptomatic hydrocephalus develops
- Keep CSF culture surveillance (as already being done)
5. CSF - Trend Toward Sterility
The CSF has notably cleared between the two lumbar puncture samples:
- 16-Jul: Reddish, turbid - RBCs + lymphocytes + polymorphs (inflammatory/hemorrhagic)
- 21-Jul: Colourless, clear - no pus cells, no organisms
This is a very encouraging trend. The turbid/hemorrhagic 16-Jul CSF was likely a combination of:
- Blood from the intraventricular extension of the cerebellar hemorrhage (traumatic/hemorrhagic vs. infective)
- Reactive pleocytosis post-surgery
The 21-Jul sample being clear and sterile, with AFB negative on both occasions and no bacterial growth, substantially reduces the probability of ventriculitis or meningitis.
- Management:
- Culture finals for 21-Jul CSF are still pending (preliminary at 22/07/2026) - await these before discontinuing any empirical antibiotics if currently on them
- If currently on empirical antibiotics (e.g., for post-neurosurgical meningitis prophylaxis), consider de-escalation/discontinuation pending culture finals
- Continue CSF monitoring if VP shunt is accessed again
- TB meningitis: Low probability given AFB negative ×2, CSF cleared, clinical picture - no empirical ATT indicated unless CSF biochemistry (protein, glucose, cell count) was abnormal (not reported here - if available, review)
- Fungal meningitis: Consider India ink stain/cryptococcal antigen if immune status is compromised
Immediate Priority Action List
| Priority | Action |
|---|---|
| Urgent | Await CSF culture final report (21-Jul sample, due ~5 days from collection) |
| Urgent | ECG + Holter to exclude AF as embolic source for new infarct |
| Urgent | Fasting lipid profile, HbA1c, fasting glucose, renal function |
| Neurosurgery review | Assessment of residual 28×32 mm hematoma - surgical vs. conservative |
| Within 48h | Strict BP monitoring and control (target 130-140 systolic in acute phase) |
| Medication | Aspirin timing decision (discuss with neurosurgeon re: residual bleed) |
| Medication | Start/continue statin therapy |
| Rehabilitation | Physiotherapy, occupational therapy - early mobilization |
| Follow-up MRI | Repeat in 2-4 weeks to assess residual hematoma resolution and infarct evolution |
Key Concerns to Watch For
- Shunt malfunction - any worsening of consciousness level, headache, vomiting
- Re-bleeding - sudden neurological deterioration, new focal deficits
- Infarct expansion - worsening of the right peritrigonal infarct into middle cerebral territory
- Post-neurosurgical meningitis - fever, meningismus, CSF pleocytosis on culture (less likely now given clear 21-Jul CSF, but finals still pending)
- Vasospasm - particularly if subarachnoid blood was present (check for this clinically)
Note: The CSF culture finals from 21-Jul 2026 are still preliminary as of today (22-Jul). Do not finalize antibiotic decisions until these results are available. The overall trajectory - clearing CSF, no organisms on any stain, stable MRI - is reassuring, but this remains a high-risk post-neurosurgical patient requiring close multi-disciplinary monitoring (neurosurgery, neurology, infectious disease if needed).
This are investigation reports
Running Command
python3 -c " from pypdf import PdfReader fname = '/tmp/workspace/attachments/7e98c105-4ed2-4073-b822-46e66d73506d/investigation.pdf' reader = PdfReader(fname) print(f'Total pages: {len(reader.pages)}') for i, page in enumerate(reader.pages): images = page.images print(f' Page {i+1}: {len(images)} images') for j, img in enumerate(images): ext = img.name.split('.')[-1] if '.' in img.name else 'jpg' out = f'/tmp/workspace/inv_p{i+1}_img{j+1}.{ext}' with open(out, 'wb') as f: f.write(img.data) print(f' Saved: {out} ({len(img.data)} bytes)') "
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python3 -c " from PIL import Image import os for i in [1, 2]: src = f'/tmp/workspace/inv_p{i}_img1.jpg' dst = f'/tmp/workspace/inv_p{i}_small.jpg' img = Image.open(src) print(f'Page {i} original size: {img.size}') img.thumbnail((1400, 1900), Image.LANCZOS) img.save(dst, 'JPEG', quality=85) print(f'Page {i} resized to: {img.size}, file size: {os.path.getsize(dst)} bytes') "
Running Command
python3 -c " from PIL import Image import os for i in [1, 2]: src = f'/tmp/workspace/inv_p{i}_img1.jpg' dst = f'/tmp/workspace/inv_p{i}_small.jpg' img = Image.open(src) img.thumbnail((1000, 1400), Image.LANCZOS) img.save(dst, 'JPEG', quality=80) print(f'Page {i}: {img.size}, {os.path.getsize(dst)} bytes') "
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Excellent - I can read both pages clearly. Now I have the complete serial investigation data. Let me compile and analyze everything.
Serial Investigation Data - Mr. Rajendra Yashwant Anjankar, 59M (ICU 4th Floor/BED-02)
Consultant: Dr. Nirmal Jaiswal | UHID: SURE00169074
Blood Group: A+ve | HIV: Non-reactive | HBsAg: Non-reactive
Complete Serial Lab Trends
| Parameter | 12/07 | 13/07 | 14/07 | 15/07 | 16/07 | 17/07 | 18/07 | 19/07 | 20/07 | 21/07 | 22/07 | Normal Range |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hb (g/dL) | 13.0 | 12.7 | 13.7 | 13.1 | 12.7 | 12.0 | 13.2 | 12.4 | 13.6 | 14.0 | 13.7 | 13–17 |
| PCV (%) | 39.8 | 38.3 | 42.2 | 40.5 | 38.5 | 36.9 | 40.1 | 41.8 | 42.0 | 42.8 | 41.4 | 40–52 |
| ESR | — | — | — | — | — | — | — | — | — | — | — | — |
| WBC (/cumm) | 23,200 | 14,900 | 14,200 | 13,100 | 11,300 | 10,200 | 12,200 | 13,700 | 13,400 | 17,100 | 17,500 | 4,000–11,000 |
| Platelets | 3,43,000 | 3,48,000 | 4,30,000 | 4 lac 824 | 4,58,000 | 5,35,000 | 613K | 610K | 5 lac 84K | 6 lac 21K | 6 lac 46K | 1.5–4.0 lac |
| Blood Urea (mg/dL) | 45 | 35 | 36 | 40 | 52 | 41 | — | 41 | 55 | 60 | 57 | 15–45 |
| Sr. Creatinine (mg/dL) | 0.9 | 0.8 | 0.80 | 0.8 | 0.75 | 0.9 | — | 0.85 | 1.0 | 1.2 | 1.05 | 0.6–1.2 |
| Sr. Sodium (mEq/L) | 143 | 138 | 134 | 187(?) | 134 | 138 | 135 | 139 | 131 | 145 | 146 | 135–145 |
| Sr. Potassium (mEq/L) | 3.4 | 3.4 | 3.7 | 4.0 | 3.8 | 3.2 | 3.7 | 4.3 | 3.6 | 3.5 | 3.9 | 3.5–5.0 |
| LDH | 2102 | — | 16.82 | 18.69 | — | — | — | — | — | — | — | 140–280 |
| PT/INR | — | — | 21.3/1.65 | 16.0/1.23 | 15.9/1.2 | 15.4/1.1 | — | 19.1/1.5 | 20.4? | — | 26/1.83 | 11–14 / 0.9–1.1 |
| PTTK | Abnormal | — | Qlmo 31.1 | Qlmo 42.0 | 41.0 | 41.0 | — | — | — | — | — | 25–35 sec |
| SGOT (AST) | 300.38 | — | 285.15 | 287.4 | — | — | — | 292.60 | Clemo | — | 310.17 | <40 |
| SGPT (ALT) | 300.38 | — | 285.15 | — | — | — | — | 292.60 | ~278 | — | 310.17 | <40 |
| Alk. Phosphatase | — | — | — | BuH | BuH | — | — | — | — | — | — | 44–147 |
| Bilirubin (I) | — | — | — | 285.3 | — | — | — | — | — | — | — | <0.8 |
| PCT (Procalcitonin) | — | 4.74 (13/2/26?) | — | — | — | — | — | — | — | 0.47 | — | <0.5 ng/mL |
| T3 | — | — | — | — | — | 0.84 | — | — | — | — | — | — |
| T4 | — | <13 (13/2/26) | — | — | — | — | — | — | — | — | — | — |
Page 2 additional findings (handwritten CSF/urine data, 18/07):
- Urine: pH 6.0, Sp.Gr 1.025 (Squamo epithelial cells 1+)
- CSF: PC 3-4 cells, EP 1-2 cells, Blood 1+, Budding yeast 2+
Critical Findings & Clinical Interpretation
🔴 ALERT: Budding Yeast in CSF (18/07/2026)
This is the most critical new finding. The 18-Jul CSF microscopy showed:
- Budding yeast 2+ in CSF
- Blood 1+ (hemorrhagic tap vs. true blood)
- PC 3-4 cells, EP 1-2 cells
This strongly suggests Cryptococcal Meningitis or other fungal ventriculitis in a post-neurosurgical patient with VP shunt. This must be acted on urgently.
Immediate actions required:
- CSF India Ink stain - if not already done
- Serum and CSF Cryptococcal Antigen (CrAg) - highly sensitive (>95%) for cryptococcal meningitis
- CSF fungal culture - on Sabouraud dextrose agar
- Start empirical antifungal therapy - do not wait for culture confirmation:
- Induction: Liposomal Amphotericin B (L-AmB) 3-4 mg/kg/day IV + Flucytosine 25 mg/kg 4 times daily (if available) for ≥2 weeks
- If Flucytosine unavailable: L-AmB alone or L-AmB + Fluconazole 400-800 mg/day
- Consolidation (after 2 weeks, if CSF sterile): Fluconazole 400 mg/day × 8 weeks
- Maintenance: Fluconazole 200 mg/day × 1 year
- Assess immune status - check CD4 count, HIV ELISA (though HIV was listed as non-reactive, reconfirm), immunosuppressant history
- Neurosurgery consultation - VP shunt in the context of fungal CNS infection requires specialized management (shunt may need to be externalized or revised)
- Serial CSF monitoring via LP or shunt tap every 2 weeks to assess treatment response
Note: The 21-Jul CSF (colourless, clear, no pus cells, no organisms on Gram/AFB) may represent temporal variation, clearance effect of empirical treatment, or sampling from a different compartment. Do not be falsely reassured - the fungal culture on 21-Jul is still pending.
🟡 Rising WBC Trend (Leukocytosis)
| Date | WBC |
|---|---|
| 14/07 | 14,200 |
| 16/07 | 11,300 (improving) |
| 17/07 | 10,200 |
| 20/07 | 13,400 |
| 21/07 | 17,100 ↑ |
| 22/07 | 17,500 ↑↑ |
- After a reassuring dip (11-12K range), WBC is rising again to 17,500 on 22/07
- This rising leukocytosis paralleling the fungal CSF finding is very concerning for ongoing CNS fungal infection / sepsis
- Differential: also consider bacterial super-infection, aspiration pneumonia, UTI, wound infection
Action: Blood cultures (if not already done), chest X-ray, urine culture, wound inspection. Review antibiotic coverage.
🟡 Thrombocytosis (Rising Platelets)
| Date | Platelets |
|---|---|
| 12/07 | 3,43,000 |
| 17/07 | 5,35,000 |
| 19/07 | 6,10,000 |
| 22/07 | 6,46,000 |
- Platelet count has nearly doubled over 10 days
- At 59-year-old male post-neurosurgical: reactive thrombocytosis due to surgery/inflammation is the most likely cause
- However, extreme thrombocytosis (>6 lac) with neurological disease carries thrombotic risk (in-situ venous/arterial thrombosis worsening lacunar infarcts)
- Action: Do not treat with platelet-lowering agents. Ensure adequate hydration. Monitor trend - if exceeds 10 lac, reassess. This will partially contraindicate aspirin until the residual cerebellar hematoma is more resolved.
🟡 Coagulopathy (PT/INR Trend)
| Date | PT | INR |
|---|---|---|
| 14/07 | 21.3 | 1.65 |
| 15/07 | 16.0 | 1.23 |
| 16/07 | 15.9 | 1.2 |
| 18/07 | 15.4 | 1.1 |
| 19/07 | 19.1 | 1.5 |
| 22/07 | 26 | 1.83 ↑↑ |
- INR was improving but has worsened again to 1.83 on 22/07 - significant coagulopathy
- PTTK also prolonged (41-42 sec) on 15-16/07
- Causes: liver dysfunction (elevated transaminases), consumption coagulopathy, nutritional deficiency (Vit K), or antifungal drug effect
- Action:
- Vitamin K 10 mg IV/IM daily × 3 days (if not on anticoagulants)
- Check fibrinogen, D-dimer to rule out DIC
- Fresh Frozen Plasma (FFP) if active bleeding or pre-procedure
- Monitor liver function - transaminases are markedly elevated
🔴 Markedly Elevated Liver Enzymes
| Parameter | 12/07 | 14/07 | 15/07 | 19/07 | 20/07 | 22/07 |
|---|---|---|---|---|---|---|
| SGOT | 300 | 285 | 287 | 293 | ~278 | 310 |
| SGPT | 300 | 285 | — | 293 | ~278 | 310 |
- SGOT/SGPT persistently 300+ units throughout admission - this is 6-8× upper limit of normal
- Causes: hepatic congestion (from raised ICP/CCF), drug-induced (antibiotics, antifungals, anticonvulsants), ischemic hepatitis, direct viral/fungal invasion
- If starting Amphotericin B: monitor LFTs closely as it is nephrotoxic and can worsen hepatic parameters
- Action:
- Review all current hepatotoxic drugs
- Check total bilirubin, GGT, Alk. Phos (some marked "BuH" = busy/high - confirm values)
- Hepatology consultation if worsening
- Check prothrombin time trend in context of liver synthetic function (INR already elevated)
🟡 Renal Function - Mild Deterioration
| Date | Urea | Creatinine |
|---|---|---|
| 12/07 | 45 | 0.9 |
| 16/07 | 52 | 0.75 |
| 20/07 | 55 | 1.0 |
| 21/07 | 60 | 1.2 |
| 22/07 | 57 | 1.05 |
- Creatinine touching 1.2 on 21/07 - borderline but trending upward from baseline ~0.75-0.9
- Important context: if initiating Amphotericin B, nephrotoxicity is a major concern. Use Liposomal formulation (less nephrotoxic than conventional AmB). Pre-hydrate with normal saline.
- Monitor urea/creatinine daily once antifungal started
🟡 Procalcitonin (PCT)
- 13/07 (or 13/02): PCT 4.74 ng/mL - HIGH (>2 = high probability of bacterial sepsis)
- 21/07: PCT 0.47 ng/mL - Normal/low (< 0.5)
- Dramatic fall in PCT suggests bacterial component has been controlled with antibiotics
- However, PCT does NOT rise with fungal infections - so a normal PCT does not exclude fungal CNS infection
Sodium Trend
- 12/07: 143 (normal), 14/07: 134 (hyponatremia), oscillates between 131-146
- 22/07: 146 (high-normal/hypernatremia)
- Post-neurosurgical hyponatremia: consider SIADH vs. cerebral salt wasting
- Current hypernatremia (146): may reflect over-correction, tube feed, or dehydration
- Action: Restrict free water if SIADH pattern; ensure adequate fluid balance; recheck in 12 hours
Updated Management Summary
Highest Priority (Do Today)
| # | Action |
|---|---|
| 1 | CSF CrAg (Cryptococcal Antigen) - serum + CSF - urgent |
| 2 | India Ink stain on stored/fresh CSF |
| 3 | CSF Fungal culture (if not already sent) |
| 4 | Start Liposomal Amphotericin B 3-4 mg/kg/day IV pending CrAg result (budding yeast in CSF is sufficient to start empirical therapy) |
| 5 | INR 1.83 + PT 26 → Vitamin K 10 mg IV/IM today; check fibrinogen, D-dimer |
| 6 | Rising WBC 17,500 → Blood cultures × 2 sets, CXR, urine culture |
| 7 | Neurosurgery consult re: VP shunt management in context of fungal CNS infection |
Ongoing Monitoring (Daily)
| Parameter | Target | Frequency |
|---|---|---|
| WBC, CRP | Downward trend | Daily |
| Urea, Creatinine | <1.2, <45 | Daily (critical once AmB started) |
| Electrolytes (Na, K) | Na 135-145, K 3.5-5.0 | Daily |
| PT/INR | Trend toward normal | Every 48 hours |
| SGOT/SGPT | Downward trend | Every 2-3 days |
| Platelets | Monitor, not treat | Every 2-3 days |
Medications to Review
| Drug | Reason |
|---|---|
| Empirical antibiotics | PCT normalized - consider de-escalation after cultures |
| Anticonvulsants | Check hepatotoxicity profile - phenytoin/valproate worsen LFTs |
| Proton pump inhibitor | Continue for stress ulcer prophylaxis (ICU patient) |
| Aspirin | Hold for now - residual cerebellar hematoma + INR 1.83 + thrombocytosis |
| Statin | Continue - hepatoprotective post-stroke benefit; monitor LFTs |
| DVT prophylaxis | Reassess - coagulopathy present but also thrombotic risk from infarcts/thrombocytosis |
Bottom line: The budding yeast in CSF from 18-Jul is the most actionable finding in this entire dataset. Combined with ongoing leukocytosis, post-neurosurgical VP shunt, worsening coagulopathy, and persistently elevated transaminases, this patient needs urgent antifungal therapy and a multidisciplinary neurosurgery + infectious disease review today. The encouraging fall in PCT and clearing 21-Jul CSF reflect bacterial infection control, but do not address the fungal component.
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