Microbiology of cerebral infections At the end of the lecture, students should be able to1. list the important organisms that cause of meningitis and encephalitis2. outline the epidemiology of the aetiological agents 3. describe the pathogenesis of meningitis and encephalitis 4. discuss the principles in management and prevention of meningitis and encephalitisAPPLIED SCIENCE STREAM- NEUROLOGY MODULE 8Pathology of cerebral infectionsAt the end of the lecture, students should be able to1. 2. 3. 4. 5. list the different aetiological agents responsible for causing meningitis in different age groups and in different clinical settings describe the macroscopic and microscopic changes in the CSF in pyogenic, viral and tuberculous meningitis indicating the important differences between them describe pathogenesis, complications and sequelae of tuberculous meningitis, pyogenic meningitis and viral meningitis assess a CSF report in a patient with meningitis and be able to evaluate the cause for the meningitis describe specific investigations in addition to bacterial cultures for establishment of the causative organism (Ex: Japanese Encephalitis IGM, CSF PCR) Antibacterial agents for cerebral infections At the end of the lecture, students should be able to1. 2. 3. 4. 5. 6. 7. 8. 9. describe the factors which influence selection of medication regime in the treatment of cerebral infectionsapply principles of pharmacodynamics and pharmacokinetics of medicines in the treatment of cerebral infections list the common cerebral infections and the causative agentsappraise the pharmacokinetics properties of an antibacterial agent to be effective in the treatment of bacterial meningitisplan pharmacological management of common bacterial meningitis in terms of agent, dosing, delivery, reason for use, spectrum, efficacy, pharmacokinetics, cautions, contra-indications, side effects, monitoring, follow up, dose, route, frequency, and durationdiscuss the pharmacological principles of management of tuberculous meningitisdescribe the pharmacological management of tuberculous meningitis including the medicines used, rationale for use, dose, dosage form, duration, adverse effects of medicines, precautions and advice to patientsname the medicines used in the treatment of fungal meningitis and cerebral toxoplasmosisdiscuss the use of corticosteroids in these infections10. discuss the use of chemoprophylaxis in these infectionsMicrobiology of specific infections (Tetanus, Rabies)At the end of the lecture, students should be able to1. 2. 3. 4. describe the basic microbiology of the aetiological agentsoutline the epidemiology of these infectionsunderstand the pathophysiology of tetanus and rabiesunderstand the pathophysiological basis of clinical features of these infectionsAPPLIED SCIENCE STREAM- NEUROLOGY MODULE 95. understand the management and prevention of tetanus and rabies infection Give a detailed explanation and qeustion

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