Inj amoxyclav according to weight
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injectable amoxicillin clavulanate co-amoxiclav IV dose mg/kg pediatric adult
Here is a complete, weight-based dosing guide for Injectable Co-amoxiclav (Amoxicillin + Clavulanate) based on standard product monographs:
Inj. Co-amoxiclav - Weight-Based Dosing
Doses expressed as Amoxicillin/Clavulanate (5:1 ratio = 1.2 g vial = 1000 mg + 200 mg)
Adults & Children ≥ 40 kg
| Severity | Dose | Frequency |
|---|---|---|
| Moderate infections | 1.2 g (1000/200 mg) | Every 8 hours |
| Severe infections | 1.2 g (1000/200 mg) | Every 6 hours |
| Max daily dose | 4.8 g/day | - |
Children < 40 kg (Pediatric Weight-Based)
| Age Group | Dose | Frequency |
|---|---|---|
| ≥ 3 months | 30 mg/kg (25 mg amox + 5 mg clav per kg) | Every 8 hours |
| Severe infections (≥ 3 months) | 30 mg/kg | Every 6 hours |
| < 3 months or < 4 kg | 30 mg/kg | Every 12 hours |
| Preterm/neonates (first week of life) | 30 mg/kg | Every 12 hours (max) |
Renal Dose Adjustment
Adults/Children ≥ 40 kg:
| CrCl | Dose |
|---|---|
| > 30 mL/min | No change |
| 10-30 mL/min | 1.2 g stat, then 600 mg every 12 hours |
| < 10 mL/min | 1.2 g stat, then 600 mg every 24 hours |
| Haemodialysis | 600 mg/24h + extra 600 mg after each dialysis session |
Children < 40 kg:
| CrCl | Dose |
|---|---|
| > 30 mL/min | No change |
| 10-30 mL/min | 30 mg/kg every 12 hours |
| < 10 mL/min | 30 mg/kg every 24 hours |
| Haemodialysis | 30 mg/kg/24h + 15 mg/kg at end of dialysis |
Surgical Prophylaxis (Adults)
- Short procedures (< 1 hour): 1.2 g at induction of anaesthesia
- Long procedures (> 1 hour): 1.2 g at induction + up to 3 doses of 1.2 g in 24 hours
Administration
| Route | Details |
|---|---|
| IV slow injection | Over 3-4 minutes directly into vein |
| IV infusion | Over 30-40 minutes |
| IM | Not suitable for IM use |
| Neonates (< 3 months) | Infusion only (not bolus) |
Key Points
- The 1.2 g vial = Amoxicillin 1000 mg + Clavulanate 200 mg (5:1 ratio)
- Elderly (> 65 yrs): No dose adjustment needed; adjust only if renal impairment present
- Hepatic impairment: Use with caution; monitor LFTs regularly
- The 10:1 ratio formulation (2000/200 mg) is dosed at 50 mg/5 mg per kg every 8-12 hours in children
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