Generate a flash card on nephron
A detailed medical flashcard titled "THE NEPHRON" for medical students. FRONT section (top half): Shows a clean labeled anatomical diagram of a nephron with all major segments clearly labeled: Glomerulus & Bowman's Capsule (Renal Corpuscle), Proximal Convoluted Tubule (PCT), Loop of Henle (thin descending limb, thin ascending limb, thick ascending limb/TAL), Distal Convoluted Tubule (DCT), and Collecting Duct. The diagram should show the cortex and medulla regions with the loop dipping into the medulla. BACK section (bottom half): Key facts organized in neat boxes: - "Functional Unit": Renal corpuscle + tubules (from PCT to connecting segment) - "Nephron Count": ~900,000 to 1 million per kidney - "PCT": Reabsorbs >60% of filtrate; brush border microvilli; NHE3 transporter; isosmotic water reabsorption via AQP1 - "Loop of Henle": Creates medullary concentration gradient; TAL has NKCC2; TAL impermeable to water - "DCT": Diluting segment; NCC cotransporter; TRPV5 calcium channel; only 10-12 mm long - "Collecting Duct": Principal cells (AQP2 + ENaC, regulated by ADH & aldosterone); intercalated cells (H+-ATPase for acid-base) Clean white background, blue and teal color scheme, professional medical education style, clear readable fonts.

| Segment | Key Points |
|---|---|
| Renal Corpuscle | Glomerulus + Bowman's capsule; origin of filtrate |
| Proximal Tubule (PCT) | Reabsorbs >60% of filtrate; brush border microvilli; NHE3 (Na+/H+ exchanger); AQP1 for water; isosmotic reabsorption |
| Loop of Henle | Creates medullary concentration gradient; TAL has NKCC2 (Na-K-2Cl cotransporter); TAL is impermeable to water; only segment creating hyperosmolar medulla |
| Distal Convoluted Tubule (DCT) | "Diluting segment"; NCC (Na-Cl cotransporter); TRPV5 (Ca2+ channel); only 10-12 mm long |
| Collecting Duct | Principal cells: AQP2 (ADH-regulated) + ENaC (aldosterone-regulated); alpha-intercalated cells: H+-ATPase (acid secretion); beta-intercalated cells: pendrin (HCO3- secretion in alkalosis) |