Brief
| Muscle | Origin | Insertion | Action |
|---|---|---|---|
| Temporalis | Temporal fossa | Coronoid process | Elevates & retracts mandible |
| Masseter | Zygomatic arch | Ramus & angle | Powerful elevator |
| Medial Pterygoid | Medial surface of lateral pterygoid plate | Medial surface of ramus | Elevates, protrudes (grinding) |
| Lateral Pterygoid | Greater wing of sphenoid | Neck of mandible & articular disc | Depresses, protrudes, side to side |
Key PYQs (Previous Year Questions) are flagged throughout - focus on TMJ type/surfaces/ligaments, muscles of mastication with origins/insertions, facial nerve course/branches, trigeminal divisions/branches, salivary gland ducts/nerve supply, cavernous sinus contents, and scalp layers.
Diagnosis
| Finding | Value | Significance |
|---|---|---|
| Fasting blood glucose | 45 mg/dL | Hypoglycemia (normal >70) - symptoms worsen with fasting, improve on eating |
| pH of blood | 7.25 | Metabolic acidosis (normal 7.35-7.45) |
| Lactate | 30 mg/dL | Lactic acidosis - lactate accumulates because G6P cannot enter glycolysis normally |
| Total ketone bodies | 6 mg/dL | Mild ketonemia from fat mobilization |
| Triacylglycerols | 400 mg/dL | Hypertriglyceridemia - excess G6P diverted to lipogenesis |
| Uric acid | 12 mg/dL | Hyperuricemia - excess G6P → pentose phosphate pathway → purine synthesis + decreased renal excretion due to competing lactate |
Glycogen / Gluconeogenesis
↓
Glucose-6-phosphate ←── G6Pase DEFICIENT
↓ (cannot dephosphorylate)
Cannot release free glucose into blood
↓
Hypoglycemia → counter-regulatory hormones ↑
↓
Excess G6P diverted to:
• Glycolysis → Lactate (lactic acidosis)
• Lipogenesis → ↑Triglycerides → fatty liver (hepatomegaly)
• Pentose phosphate pathway → ↑Purines → Hyperuricemia
"FLUK" - Fasting hypoglycemia + Lactic acidosis + Uric acid elevated + Ketones + Triglycerides elevated