mkdir -p /home/daytona/workspace/tb-pharmacology-ppt

~/tb-pharmacology-ppt/build.js

const pptxgen = require("pptxgenjs");
const { execSync } = require("child_process");

// Download the 10 lecture images
const imageUrls = [
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113925-1783520658968-r2erzb.jpg",
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113926-1783520661846-t9gz8g.jpg",
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113927-1783520683950-kejnaq.jpg",
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113928-1783520687065-yhv7sc.jpg",
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113930-1783520688645-bwo5zx.jpg",
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113931-1783520689283-rtvhsq.jpg",
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113932-1783520690319-4h6g2k.jpg",
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113934-1783520691465-c35qkp.jpg",
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113935-1783520692876-2lrk0w.jpg",
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113936-1783520694517-uilhjr.jpg"
];

console.log("Fetching images...");
const fetchCmd = `node /home/daytona/skills/shared/scripts/fetch_images.js ${imageUrls.map(u => `"${u}"`).join(" ")}`;
const imagesRaw = execSync(fetchCmd, { maxBuffer: 50 * 1024 * 1024 }).toString();
const images = JSON.parse(imagesRaw);
console.log(`Fetched ${images.length} images, errors: ${images.filter(i=>i.error).length}`);

// ─── Color palette ───────────────────────────────────────────────
const DARK_BG    = "0D1B2A";  // deep navy
const MID_BG     = "1B2A3B";  // slightly lighter navy
const ACCENT1    = "E63946";  // red-scarlet
const ACCENT2    = "F4A261";  // warm amber
const ACCENT3    = "2A9D8F";  // teal-green
const WHITE      = "FFFFFF";
const LIGHT_GRAY = "D9E4EE";
const YELLOW     = "FFD60A";
const PURPLE     = "C77DFF";
const GREEN      = "57CC99";

let pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.author  = "Cerebellum | Get the Balance Right";
pres.title   = "Anti-TB Drugs – Pharmacology";

// ─── Helper: section-header bar ──────────────────────────────────
function addSectionBar(slide, text, color) {
  slide.addShape(pres.ShapeType.rect, {
    x: 0, y: 0, w: 10, h: 0.72,
    fill: { color: color || ACCENT1 }, line: { type: "none" }
  });
  slide.addText(text, {
    x: 0.25, y: 0, w: 9.5, h: 0.72,
    fontSize: 22, bold: true, color: WHITE, valign: "middle", margin: 0
  });
}

// ─── Helper: full dark background ────────────────────────────────
function darkBg(slide) {
  slide.background = { color: DARK_BG };
}
function midBg(slide) {
  slide.background = { color: MID_BG };
}

// ====================================================
// SLIDE 1 – TITLE SLIDE
// ====================================================
{
  let slide = pres.addSlide();
  darkBg(slide);

  // Decorative rectangles
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:0.18, h:5.625, fill:{ color: ACCENT1 }, line:{ type:"none" } });
  slide.addShape(pres.ShapeType.rect, { x:0.18, y:0, w:0.08, h:5.625, fill:{ color: ACCENT2 }, line:{ type:"none" } });
  slide.addShape(pres.ShapeType.rect, { x:0, y:4.9, w:10, h:0.725, fill:{ color: ACCENT3 }, line:{ type:"none" } });

  slide.addText("ANTI-TB DRUGS", {
    x:0.5, y:0.7, w:9, h:1.2,
    fontSize:52, bold:true, color:WHITE, align:"center", charSpacing:6
  });
  slide.addText("Pharmacology of Tuberculosis Treatment", {
    x:0.5, y:1.9, w:9, h:0.6,
    fontSize:22, color:ACCENT2, align:"center", italic:true
  });
  slide.addShape(pres.ShapeType.line, { x:1, y:2.65, w:8, h:0, line:{ color:ACCENT1, width:2 } });

  slide.addText([
    { text: "Topics Covered:", options: { bold:true, color:ACCENT2, breakLine:true } },
    { text: "• Drug Classification (1st & 2nd Line)   • Drug Properties   • Bactericidal Activity", options:{ color:LIGHT_GRAY, breakLine:true } },
    { text: "• Isoniazid (MOA, ADRs, Metabolism)   • Rifampicin (MOA, Properties, Comparison)", options:{ color:LIGHT_GRAY } }
  ], { x:0.6, y:2.85, w:8.8, h:1.8, fontSize:15 });

  slide.addText("Cerebellum | Get the Balance Right", {
    x:0, y:4.9, w:10, h:0.725,
    fontSize:14, color:WHITE, align:"center", valign:"middle", bold:true, margin:0
  });
}

// ====================================================
// SLIDE 2 – TB DRUG CLASSIFICATION
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 1 — TB Drug Classification", ACCENT1);

  // TB box
  slide.addShape(pres.ShapeType.rect, { x:4, y:1.0, w:2, h:0.7, fill:{ color:ACCENT1 }, line:{color:WHITE, width:2} });
  slide.addText("TB", { x:4, y:1.0, w:2, h:0.7, fontSize:28, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });

  // Left branch line
  slide.addShape(pres.ShapeType.line, { x:3.1, y:1.35, w:0.9, h:0, line:{ color:WHITE, width:2 } });
  // Right branch line
  slide.addShape(pres.ShapeType.line, { x:6, y:1.35, w:0.9, h:0, line:{ color:WHITE, width:2 } });

  // 1st Line box (left)
  slide.addShape(pres.ShapeType.rect, { x:1.2, y:0.85, w:1.9, h:0.65, fill:{color:ACCENT3}, line:{color:WHITE,width:1.5} });
  slide.addText("1st Line", { x:1.2, y:0.85, w:1.9, h:0.65, fontSize:18, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });

  // 2nd Line box (right)
  slide.addShape(pres.ShapeType.rect, { x:6.9, y:0.85, w:1.9, h:0.65, fill:{color:ACCENT2}, line:{color:WHITE,width:1.5} });
  slide.addText("2nd Line", { x:6.9, y:0.85, w:1.9, h:0.65, fontSize:18, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });

  // 1st Line drugs
  const drugs1 = [
    ["H", "Isoniazid",    ACCENT1,  "Most important; bactericidal"],
    ["R", "Rifampicin",   ACCENT2,  "Most effective; enzyme inducer"],
    ["Z", "Pyrazinamide", PURPLE,   "Best sterilizing; avoid in pregnancy"],
    ["E", "Ethambutol",   ACCENT3,  "Bacteriostatic; given orally"],
    ["S", "Streptomycin", LIGHT_GRAY,"Extracellular; C/I in pregnancy"],
  ];
  drugs1.forEach(([abbr, name, col, note], i) => {
    const y = 1.75 + i * 0.68;
    slide.addShape(pres.ShapeType.rect, { x:0.3, y, w:0.55, h:0.55, fill:{color:col}, line:{type:"none"} });
    slide.addText(abbr, { x:0.3, y, w:0.55, h:0.55, fontSize:20, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
    slide.addText(name, { x:1.0, y:y+0.03, w:2.5, h:0.5, fontSize:16, bold:true, color:WHITE, valign:"middle" });
    slide.addText(note, { x:3.6, y:y+0.03, w:3.2, h:0.5, fontSize:12, color:LIGHT_GRAY, valign:"middle" });
  });

  // ORAL label
  slide.addText("ORAL →", { x:0.3, y:1.75, w:0.9, h:2.8, fontSize:13, color:ACCENT2, bold:true, rotate:270, valign:"middle", align:"center" });

  // 2nd Line note
  slide.addShape(pres.ShapeType.rect, { x:6.8, y:1.75, w:2.9, h:3.5, fill:{color:"1A2A3A"}, line:{color:ACCENT2,width:1.5} });
  slide.addText([
    { text:"2nd Line Drugs Include:", options:{bold:true, color:ACCENT2, breakLine:true} },
    { text:"• Fluoroquinolones\n  (Levofloxacin, Moxifloxacin)", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"• Injectable agents\n  (Amikacin, Capreomycin)", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"• Cycloserine\n• Ethionamide\n• PAS", options:{color:LIGHT_GRAY} }
  ], { x:6.9, y:1.8, w:2.7, h:3.3, fontSize:12, valign:"top" });

  // Blue underline for S
  slide.addShape(pres.ShapeType.line, { x:0.3, y:5.27, w:6.5, h:0, line:{color:ACCENT1,width:1.5,dashType:"dash"} });
  slide.addText("★ S (Streptomycin) is NOT oral — given by injection", {
    x:0.3, y:5.3, w:6.4, h:0.3, fontSize:11, color:ACCENT2, italic:true
  });
}

// ====================================================
// SLIDE 3 – DRUG PROPERTIES TABLE
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 2 — Drug Properties: Activity, Type, Hepatotoxicity & Pregnancy", ACCENT3);

  const headers = ["Drug", "Activity", "Type", "Hepatotoxic", "Pregnancy"];
  const colW = [0.9, 1.55, 1.65, 1.85, 1.85];
  const colX = [0.25, 1.15, 2.7, 4.35, 6.2];
  const rowH = 0.72;
  const startY = 0.85;

  // Header row
  headers.forEach((h, i) => {
    slide.addShape(pres.ShapeType.rect, { x:colX[i], y:startY, w:colW[i], h:0.5, fill:{color:ACCENT1}, line:{type:"none"} });
    slide.addText(h, { x:colX[i], y:startY, w:colW[i], h:0.5, fontSize:13, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
  });

  const rows = [
    { drug:"H", fullName:"Isoniazid",    activity:"Cidal", type:"Both (I/C + E/C)", hepato:"✓", hepatoCol:ACCENT1, pregnancy:"✓ Safe", pregCol:GREEN },
    { drug:"R", fullName:"Rifampicin",   activity:"Cidal", type:"Both (I/C + E/C)", hepato:"✓", hepatoCol:ACCENT1, pregnancy:"✓ Safe", pregCol:GREEN },
    { drug:"Z", fullName:"Pyrazinamide", activity:"Cidal", type:"I/C Only",         hepato:"✓✓✓ Max",hepatoCol:"CC0000", pregnancy:"⚠ AVOID", pregCol:ACCENT2 },
    { drug:"E", fullName:"Ethambutol",   activity:"Static",type:"Both (I/C + E/C)", hepato:"✗ No",  hepatoCol:ACCENT3, pregnancy:"✓ Safe", pregCol:GREEN },
    { drug:"S", fullName:"Streptomycin", activity:"Cidal", type:"E/C Only",         hepato:"✗ No",  hepatoCol:ACCENT3, pregnancy:"✗ C/I",  pregCol:ACCENT1 },
  ];

  rows.forEach((row, i) => {
    const y = startY + 0.5 + (i * rowH);
    const bg = i % 2 === 0 ? "162030" : "1E2E42";
    slide.addShape(pres.ShapeType.rect, { x:0.25, y, w:9.5, h:rowH-0.04, fill:{color:bg}, line:{type:"none"} });
    // Drug abbr
    slide.addShape(pres.ShapeType.rect, { x:colX[0]+0.05, y:y+0.1, w:0.5, h:0.52, fill:{color:ACCENT1}, line:{type:"none"} });
    slide.addText(row.drug, { x:colX[0]+0.05, y:y+0.1, w:0.5, h:0.52, fontSize:18, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
    // Full name below
    slide.addText(row.fullName, { x:colX[0]+0.05, y:y+0.42, w:0.85, h:0.25, fontSize:8, color:LIGHT_GRAY, align:"center" });
    // Activity
    const actCol = row.activity === "Static" ? ACCENT2 : GREEN;
    slide.addShape(pres.ShapeType.roundRect, { x:colX[1]+0.1, y:y+0.12, w:1.2, h:0.45, fill:{color:actCol}, line:{type:"none"}, rectRadius:0.1 });
    slide.addText(row.activity, { x:colX[1]+0.1, y:y+0.12, w:1.2, h:0.45, fontSize:13, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
    // Type
    slide.addText(row.type, { x:colX[2]+0.05, y:y+0.1, w:1.55, h:0.52, fontSize:12, color:LIGHT_GRAY, valign:"middle" });
    // Hepatotoxic
    slide.addShape(pres.ShapeType.roundRect, { x:colX[3]+0.2, y:y+0.12, w:1.2, h:0.45, fill:{color:row.hepatoCol}, line:{type:"none"}, rectRadius:0.1 });
    slide.addText(row.hepato, { x:colX[3]+0.2, y:y+0.12, w:1.2, h:0.45, fontSize:12, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
    // Pregnancy
    slide.addShape(pres.ShapeType.roundRect, { x:colX[4]+0.2, y:y+0.12, w:1.35, h:0.45, fill:{color:row.pregCol}, line:{type:"none"}, rectRadius:0.1 });
    slide.addText(row.pregnancy, { x:colX[4]+0.2, y:y+0.12, w:1.35, h:0.45, fontSize:12, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
  });

  // Key note
  slide.addText("★ Z = Most hepatotoxic | E = Only Bacteriostatic | S = Contraindicated in Pregnancy", {
    x:0.25, y:5.22, w:9.5, h:0.35,
    fontSize:12, color:ACCENT2, bold:true, align:"center"
  });
}

// ====================================================
// SLIDE 4 – BACTERICIDAL ACTIVITY (Fast/Intermittent/Slow)
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 3 — Bactericidal Activity by Growth Rate", ACCENT2);

  const groups = [
    {
      speed: "FAST Growing",
      loc: "Wall of Cavity",
      drug: "H (Isoniazid)",
      label: "BEST Overall",
      col: ACCENT1,
      icon: "🔴",
      desc: "Isoniazid is BEST for fast-growing bacilli found in the wall of cavities. Bactericidal."
    },
    {
      speed: "INTERMITTENT (Spurters)",
      loc: "Caseous Necrosis",
      drug: "R (Rifampicin)",
      label: "Caseous Foci",
      col: ACCENT2,
      icon: "🟠",
      desc: "Rifampicin targets intermittently growing bacilli (spurters) in caseous necrosis."
    },
    {
      speed: "SLOW Growing",
      loc: "Intracellular (I/C)",
      drug: "Z (Pyrazinamide)",
      label: "BEST Sterilizing",
      col: PURPLE,
      icon: "🟣",
      desc: "Pyrazinamide has the BEST sterilizing activity against slow/intracellular bacilli. Active in acidic pH."
    }
  ];

  groups.forEach((g, i) => {
    const y = 0.9 + i * 1.5;
    // Speed badge
    slide.addShape(pres.ShapeType.rect, { x:0.25, y, w:2.6, h:0.6, fill:{color:g.col}, line:{type:"none"} });
    slide.addText(g.speed, { x:0.25, y, w:2.6, h:0.6, fontSize:14, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
    // Arrow
    slide.addShape(pres.ShapeType.line, { x:2.85, y:y+0.3, w:0.4, h:0, line:{color:g.col, width:2} });
    // Location
    slide.addShape(pres.ShapeType.roundRect, { x:3.25, y:y+0.05, w:2.2, h:0.5, fill:{color:"1A2A3A"}, line:{color:g.col,width:1.5}, rectRadius:0.1 });
    slide.addText(g.loc, { x:3.25, y:y+0.05, w:2.2, h:0.5, fontSize:13, color:WHITE, align:"center", valign:"middle", margin:0 });
    // Arrow 2
    slide.addShape(pres.ShapeType.line, { x:5.45, y:y+0.3, w:0.4, h:0, line:{color:g.col,width:2} });
    // Drug badge
    slide.addShape(pres.ShapeType.rect, { x:5.85, y, w:2.0, h:0.6, fill:{color:g.col}, line:{type:"none"} });
    slide.addText(g.drug, { x:5.85, y, w:2.0, h:0.6, fontSize:15, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
    // Label
    slide.addShape(pres.ShapeType.roundRect, { x:7.95, y, w:1.8, h:0.6, fill:{color:DARK_BG}, line:{color:YELLOW,width:1.5}, rectRadius:0.1 });
    slide.addText(g.label, { x:7.95, y, w:1.8, h:0.6, fontSize:12, bold:true, color:YELLOW, align:"center", valign:"middle", margin:0 });
    // Description
    slide.addText(g.desc, { x:0.35, y:y+0.65, w:9.3, h:0.55, fontSize:12, color:LIGHT_GRAY, italic:true });
    // Divider
    if (i < 2) slide.addShape(pres.ShapeType.line, { x:0.25, y:y+1.38, w:9.5, h:0, line:{color:"2A3A4A", width:1} });
  });

  slide.addText("Slow acetylators accumulate more INH → Higher risk of Peripheral Neuropathy (Pyridoxine deficiency)", {
    x:0.25, y:5.22, w:9.5, h:0.35, fontSize:11, color:ACCENT2, italic:true, align:"center"
  });
}

// ====================================================
// SLIDE 5 – ISONIAZID: MOA
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 4 — Isoniazid (H): Mechanism of Action", ACCENT1);

  // Drug label box
  slide.addShape(pres.ShapeType.rect, { x:0.3, y:0.9, w:1.5, h:0.65, fill:{color:ACCENT1}, line:{type:"none"} });
  slide.addText("① H", { x:0.3, y:0.9, w:1.5, h:0.65, fontSize:22, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
  slide.addShape(pres.ShapeType.rect, { x:1.95, y:0.9, w:1.6, h:0.65, fill:{color:"1A2A3A"}, line:{color:ACCENT1,width:2} });
  slide.addText("MOA", { x:1.95, y:0.9, w:1.6, h:0.65, fontSize:22, bold:true, color:ACCENT2, align:"center", valign:"middle", margin:0 });

  // Flow chart
  const steps = [
    { text:"Isoniazid (H) — Prodrug", col:ACCENT1, y:1.75 },
    { text:"↓  Activated by  Catalase-Peroxidase  (Kat G)*", col:ACCENT2, y:2.3 },
    { text:"Active Metabolite", col:GREEN, y:2.85 },
    { text:"↓  Inhibits  ACP reductase  (Inh A)*", col:ACCENT2, y:3.4 },
    { text:"⊖  Mycolic Acid Synthesis  BLOCKED", col:ACCENT1, y:3.95 },
    { text:"→  Cell wall destruction → Bactericidal", col:GREEN, y:4.5 },
  ];

  steps.forEach(s => {
    const isBig = [1.75, 2.85, 3.95].includes(s.y);
    slide.addShape(pres.ShapeType.rect, {
      x: 1.5, y: s.y, w: 7.2, h: 0.48,
      fill: { color: isBig ? "1E2E42" : DARK_BG },
      line: { color: s.col, width: isBig ? 2 : 1 }
    });
    slide.addText(s.text, {
      x:1.55, y:s.y+0.02, w:7.1, h:0.44,
      fontSize: isBig ? 16 : 14,
      bold: isBig,
      color: s.col,
      align:"center", valign:"middle"
    });
  });

  // Side note
  slide.addText("* Kat G mutations → INH resistance   |   * Inh A mutations → Low-level INH resistance", {
    x:0.3, y:5.2, w:9.4, h:0.35, fontSize:11, color:LIGHT_GRAY, italic:true, align:"center"
  });
}

// ====================================================
// SLIDE 6 – ISONIAZID: SIDE EFFECTS (Pyridoxine & SHIP)
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 5 — Isoniazid: Side Effects — Pyridoxine Deficiency & SHIP Mnemonic", PURPLE);

  // Left panel: Pyridoxine deficiency
  slide.addShape(pres.ShapeType.rect, { x:0.2, y:0.85, w:4.5, h:2.4, fill:{color:"1A2A3A"}, line:{color:PURPLE,width:2} });
  slide.addText("② Pyridoxine (B₆) Deficiency", {
    x:0.3, y:0.9, w:4.3, h:0.45,
    fontSize:14, bold:true, color:PURPLE
  });
  slide.addText([
    { text:"INH competes with/depletes Pyridoxal phosphate", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"→ Peripheral Neuropathy (PN)", options:{color:ACCENT1, bold:true, breakLine:true} },
    { text:"\nPrevention: Vitamin B₆ supplement", options:{color:GREEN, breakLine:true} },
    { text:"Treatment: Vitamin B₆ (high dose)", options:{color:GREEN} }
  ], { x:0.3, y:1.4, w:4.3, h:1.75, fontSize:13 });

  // Right panel: SHIP
  slide.addShape(pres.ShapeType.rect, { x:5.0, y:0.85, w:4.7, h:2.4, fill:{color:"1A2A3A"}, line:{color:ACCENT2,width:2} });
  slide.addText("③ S.H.I.P Mnemonic — Side Effects", {
    x:5.1, y:0.9, w:4.5, h:0.45,
    fontSize:14, bold:true, color:ACCENT2
  });
  const ship = [
    { letter:"S", full:"Seizures / CNS effects" },
    { letter:"H", full:"Hepatotoxicity" },
    { letter:"I", full:"INH → SLE-like syndrome (via Acetylation)" },
    { letter:"P", full:"Peripheral Neuropathy (B₆ deficiency)" }
  ];
  ship.forEach((item, i) => {
    slide.addShape(pres.ShapeType.rect, { x:5.1, y:1.4+i*0.4, w:0.38, h:0.34, fill:{color:ACCENT2}, line:{type:"none"} });
    slide.addText(item.letter, { x:5.1, y:1.4+i*0.4, w:0.38, h:0.34, fontSize:14, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
    slide.addText(item.full, { x:5.55, y:1.42+i*0.4, w:4.0, h:0.34, fontSize:12, color:LIGHT_GRAY, valign:"middle" });
  });

  // Bottom: Acetylation & SLE
  slide.addShape(pres.ShapeType.rect, { x:0.2, y:3.45, w:9.5, h:1.95, fill:{color:"162030"}, line:{color:ACCENT1,width:2} });
  slide.addText("③ Acetylation Genetics → Drug-Induced SLE", {
    x:0.35, y:3.5, w:9.2, h:0.42,
    fontSize:15, bold:true, color:ACCENT1
  });
  slide.addText([
    { text:"• Slow Acetylators: ", options:{bold:true, color:ACCENT2} },
    { text:"More PN (peripheral neuropathy)  |  Higher INH plasma levels  |  More SLE risk", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"• Fast Acetylators: ", options:{bold:true, color:ACCENT2} },
    { text:"More Hepatotoxicity  |  Lower plasma levels  |  Less PN", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"• SLE-inducing drugs: S-H-I-P  → ", options:{bold:true, color:PURPLE} },
    { text:"all undergo Acetylation metabolism", options:{color:LIGHT_GRAY} }
  ], { x:0.35, y:3.96, w:9.2, h:1.38, fontSize:12 });
}

// ====================================================
// SLIDE 7 – ISONIAZID: ACETYLATION & HEPATOTOXICITY
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 6 — Isoniazid: Acetylation Metabolism & Hepatotoxicity", ACCENT1);

  // Flow: INH acetylation pathway
  slide.addText("INH Metabolism — Acetylation Pathway", {
    x:0.3, y:0.85, w:9.4, h:0.45,
    fontSize:16, bold:true, color:ACCENT2, align:"center"
  });

  // Central INH box
  slide.addShape(pres.ShapeType.rect, { x:3.8, y:1.45, w:2.4, h:0.65, fill:{color:ACCENT1}, line:{type:"none"} });
  slide.addText("INH", { x:3.8, y:1.45, w:2.4, h:0.65, fontSize:22, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });

  // Fast path (top)
  slide.addShape(pres.ShapeType.line, { x:3.8, y:1.77, w:-1.2, h:0, line:{color:PURPLE,width:2} });
  slide.addText("Fast Acetylators", { x:1.2, y:1.5, w:1.6, h:0.55, fontSize:12, bold:true, color:PURPLE, align:"center" });

  // Slow path (bottom-left arrow to PN box)
  slide.addShape(pres.ShapeType.line, { x:3.8, y:1.77, w:0, h:0.8, line:{color:ACCENT2,width:2} });
  slide.addText("Slow Acetylators →", { x:1.2, y:2.7, w:2.2, h:0.45, fontSize:12, bold:true, color:ACCENT2 });

  // NAT enzyme
  slide.addShape(pres.ShapeType.roundRect, { x:1.4, y:2.0, w:2.1, h:0.48, fill:{color:"1A2A3A"}, line:{color:PURPLE,width:1.5}, rectRadius:0.1 });
  slide.addText("NAT (N-Acetyltransferase)", { x:1.4, y:2.0, w:2.1, h:0.48, fontSize:11, color:PURPLE, align:"center", valign:"middle" });

  // Acetyl-INH
  slide.addShape(pres.ShapeType.rect, { x:3.5, y:2.55, w:3, h:0.6, fill:{color:"1A2A3A"}, line:{color:ACCENT2,width:2} });
  slide.addText("Acetyl-INH", { x:3.5, y:2.55, w:3, h:0.6, fontSize:16, bold:true, color:ACCENT2, align:"center", valign:"middle", margin:0 });
  slide.addShape(pres.ShapeType.line, { x:5, y:3.15, w:0, h:0.35, line:{color:ACCENT2,width:2} });

  // Acetyl hydrazine
  slide.addShape(pres.ShapeType.rect, { x:3.3, y:3.5, w:3.4, h:0.55, fill:{color:"1A2A3A"}, line:{color:ACCENT1,width:2} });
  slide.addText("Acetyl Hydrazine", { x:3.3, y:3.5, w:3.4, h:0.55, fontSize:15, bold:true, color:ACCENT1, align:"center", valign:"middle", margin:0 });
  slide.addShape(pres.ShapeType.line, { x:5, y:4.05, w:0, h:0.35, line:{color:ACCENT1,width:2} });

  // Hepatotoxic
  slide.addShape(pres.ShapeType.rect, { x:3.0, y:4.4, w:4, h:0.7, fill:{color:ACCENT1}, line:{color:"CC0000",width:3} });
  slide.addText("⚠ HEPATOTOXIC", { x:3.0, y:4.4, w:4, h:0.7, fontSize:20, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });

  // PN box (slow acetylators)
  slide.addShape(pres.ShapeType.rect, { x:0.2, y:3.5, w:2.7, h:1.5, fill:{color:"162030"}, line:{color:ACCENT2,width:2} });
  slide.addText([
    { text:"Slow Acetylators\n", options:{bold:true, color:ACCENT2, breakLine:true} },
    { text:"✓ More Peripheral Neuropathy\n", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"✓ More SLE\n", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"✓ Less Hepatotoxicity", options:{color:GREEN} }
  ], { x:0.3, y:3.55, w:2.5, h:1.4, fontSize:12, valign:"top" });

  // Fast acetylators note
  slide.addShape(pres.ShapeType.rect, { x:7.1, y:3.5, w:2.7, h:1.5, fill:{color:"162030"}, line:{color:PURPLE,width:2} });
  slide.addText([
    { text:"Fast Acetylators\n", options:{bold:true, color:PURPLE, breakLine:true} },
    { text:"✓ More Hepatotoxicity\n", options:{color:ACCENT1, breakLine:true} },
    { text:"✓ Less PN/SLE\n", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"✓ More INH → PN (INH→PN): slow", options:{color:LIGHT_GRAY} }
  ], { x:7.2, y:3.55, w:2.5, h:1.4, fontSize:12, valign:"top" });
}

// ====================================================
// SLIDE 8 – RIFAMPICIN: MOA
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 7 — Rifampicin (R): Mechanism of Action", ACCENT3);

  slide.addShape(pres.ShapeType.rect, { x:0.3, y:0.9, w:1.5, h:0.65, fill:{color:ACCENT3}, line:{type:"none"} });
  slide.addText("② R", { x:0.3, y:0.9, w:1.5, h:0.65, fontSize:22, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
  slide.addShape(pres.ShapeType.rect, { x:1.95, y:0.9, w:1.6, h:0.65, fill:{color:"1A2A3A"}, line:{color:ACCENT3,width:2} });
  slide.addText("MOA", { x:1.95, y:0.9, w:1.6, h:0.65, fontSize:22, bold:true, color:ACCENT2, align:"center", valign:"middle", margin:0 });

  // rpoB gene note
  slide.addShape(pres.ShapeType.roundRect, { x:6.5, y:0.85, w:3.2, h:0.72, fill:{color:"1A2A3A"}, line:{color:YELLOW,width:2}, rectRadius:0.1 });
  slide.addText("★ Gene: rpoB — Resistance marker", { x:6.5, y:0.85, w:3.2, h:0.72, fontSize:13, bold:true, color:YELLOW, align:"center", valign:"middle" });

  // Flow diagram
  const rSteps = [
    { label:"Rifampicin", col:ACCENT3, y:1.75 },
    { label:"Binds β-subunit of RNA Polymerase (rpoB)", col:ACCENT2, y:2.35 },
    { label:"⊖ Inhibits Transcription", col:ACCENT1, y:2.95 },
    { label:"No mRNA → No Protein Synthesis", col:LIGHT_GRAY, y:3.55 },
    { label:"Bacterial Cell Death → BACTERICIDAL", col:GREEN, y:4.15 },
  ];
  rSteps.forEach((s, i) => {
    const big = i % 2 === 0;
    slide.addShape(pres.ShapeType.rect, { x:1.5, y:s.y, w:7.5, h:0.52, fill:{color:big?"1E2E42":DARK_BG}, line:{color:s.col,width:big?2:1} });
    slide.addText(s.text || s.label, { x:1.55, y:s.y+0.02, w:7.4, h:0.48, fontSize:big?16:14, bold:big, color:s.col, align:"center", valign:"middle" });
    if (i < rSteps.length-1) {
      slide.addShape(pres.ShapeType.line, { x:5.25, y:s.y+0.52, w:0, h:0.3, line:{color:s.col,width:2} });
    }
  });

  slide.addText("rpoB gene mutation → Rifampicin resistance (used as marker for MDR-TB diagnosis by GeneXpert)", {
    x:0.3, y:4.88, w:9.4, h:0.38, fontSize:11, color:ACCENT2, italic:true, align:"center"
  });
}

// ====================================================
// SLIDE 9 – RIFAMPICIN: KEY PHARMACOLOGICAL FEATURES
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 8 — Rifampicin: Key Pharmacological Features & Drug Interactions", ACCENT2);

  const features = [
    {
      letter:"a)", label:"Empty Stomach",
      col: ACCENT3,
      body:"Must be taken on an EMPTY STOMACH for optimal absorption. Food significantly reduces bioavailability."
    },
    {
      letter:"b)", label:"Excreted in Bile",
      col: ACCENT1,
      body:"Rifampicin is excreted in bile → enterohepatic circulation. Can colour bile orange."
    },
    {
      letter:"c)", label:"Enzyme Inducer (CYP450)",
      col: ACCENT2,
      body:"Potent CYP450 inducer → reduces levels of: Warfarin (→ use Heparin), OCP (→ use other method), Anti-HIV drugs (→ switch to Rifabutin)"
    },
  ];

  features.forEach((f, i) => {
    const y = 0.9 + i * 1.5;
    slide.addShape(pres.ShapeType.rect, { x:0.25, y, w:0.55, h:1.28, fill:{color:f.col}, line:{type:"none"} });
    slide.addText(f.letter, { x:0.25, y, w:0.55, h:1.28, fontSize:16, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
    slide.addShape(pres.ShapeType.rect, { x:0.8, y, w:9.0, h:1.28, fill:{color:"162030"}, line:{color:f.col,width:2} });
    slide.addText(f.label, { x:0.95, y:y+0.05, w:8.7, h:0.42, fontSize:15, bold:true, color:f.col });
    slide.addText(f.body, { x:0.95, y:y+0.5, w:8.7, h:0.7, fontSize:12, color:LIGHT_GRAY });
  });

  slide.addText("Anti-HIV + Rifampicin → Replace Rifampicin with RIFABUTIN (less enzyme induction, safer for HIV patients)", {
    x:0.25, y:5.22, w:9.5, h:0.35, fontSize:11, color:YELLOW, bold:true, align:"center"
  });
}

// ====================================================
// SLIDE 10 – RIFAMPICIN vs RIFABUTIN COMPARISON
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 9 — Rifampicin vs Rifabutin: Head-to-Head Comparison", ACCENT1);

  const cols = [
    { name:"Rifampicin (Rcin)", col:ACCENT1, x:0.3 },
    { name:"Rifabutin",         col:ACCENT3, x:5.2 }
  ];

  cols.forEach(c => {
    slide.addShape(pres.ShapeType.rect, { x:c.x, y:0.85, w:4.6, h:0.6, fill:{color:c.col}, line:{type:"none"} });
    slide.addText(c.name, { x:c.x, y:0.85, w:4.6, h:0.6, fontSize:18, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
  });

  const rows = [
    { label:"TB Efficacy",     rcin:"Most Effective ✓✓✓", rfb:"Less Effective ✓" },
    { label:"MAC Efficacy",    rcin:"Less Effective",      rfb:"More Effective ✓" },
    { label:"Enzyme Induction",rcin:"Strong (CYP450) ✓✓✓",rfb:"Weaker (less induction)" },
    { label:"HIV Compatibility",rcin:"Avoid (↓ ART levels)",rfb:"Preferred with HIV/ART ✓" },
    { label:"Hepatotoxicity",  rcin:"Yes ✓",               rfb:"Same" },
    { label:"Unique ADR",      rcin:"Pseudojaundice",       rfb:"Uveitis ★" },
    { label:"Body Secretions", rcin:"Orange (urine/tears)", rfb:"Orange (same)" },
  ];

  rows.forEach((row, i) => {
    const y = 1.55 + i*0.55;
    const bg = i%2===0?"162030":"1A2A3A";
    slide.addShape(pres.ShapeType.rect, { x:0.3, y, w:9.5, h:0.52, fill:{color:bg}, line:{type:"none"} });
    slide.addText(row.label, { x:0.35, y:y+0.05, w:1.6, h:0.42, fontSize:11, bold:true, color:ACCENT2, valign:"middle" });
    slide.addShape(pres.ShapeType.line, { x:1.95, y:y+0.05, w:0, h:0.42, line:{color:"2A3A4A",width:1} });
    slide.addText(row.rcin, { x:2.0, y:y+0.05, w:3.0, h:0.42, fontSize:12, color: row.rcin.includes("✓")?GREEN:(row.rcin.includes("Avoid"))?ACCENT1:LIGHT_GRAY, valign:"middle" });
    slide.addShape(pres.ShapeType.line, { x:5.15, y:y+0.05, w:0, h:0.42, line:{color:"2A3A4A",width:1} });
    slide.addText(row.rfb, { x:5.2, y:y+0.05, w:3.4, h:0.42, fontSize:12, color: row.rfb.includes("✓")||row.rfb.includes("Preferred")?GREEN:(row.rfb.includes("Uveitis"))?ACCENT1:LIGHT_GRAY, valign:"middle" });
  });

  slide.addText("Key Takeaway: Use Rifabutin instead of Rifampicin when patient is on Anti-HIV (ART) therapy", {
    x:0.3, y:5.4, w:9.4, h:0.2, fontSize:11, color:YELLOW, bold:true, align:"center"
  });
}

// ====================================================
// SLIDE 11 – RIFAMPICIN: ORANGE SECRETIONS
// ====================================================
{
  let slide = pres.addSlide();
  midBg(slide);
  addSectionBar(slide, "TOPIC 10 — Rifampicin: Orange Coloured Secretions", ACCENT2);

  slide.addText("d) All Body Secretions Turn Orange-Red", {
    x:0.3, y:0.85, w:9.4, h:0.5,
    fontSize:18, bold:true, color:ACCENT2, align:"center"
  });

  const secretions = [
    { label:"Urine", icon:"💧", note:"Classic finding — orange/red urine. Do NOT confuse with haematuria.", col:ACCENT1 },
    { label:"Tears", icon:"😢", note:"Tears turn orange → causes permanent contact lens staining.", col:ACCENT3 },
    { label:"Sweat", icon:"💦", note:"Sweat, saliva, sputum — all body fluids stained orange.", col:PURPLE },
    { label:"Breast Milk", icon:"🍼", note:"Orange-coloured breast milk — important in lactating mothers.", col:ACCENT2 },
  ];

  secretions.forEach((s, i) => {
    const col = i % 2 === 0 ? 0 : 5;
    const row = Math.floor(i / 2);
    const x = col === 0 ? 0.3 : 5.2;
    const y = 1.55 + row * 2.0;
    slide.addShape(pres.ShapeType.rect, { x, y, w:4.6, h:1.75, fill:{color:"162030"}, line:{color:s.col,width:2} });
    slide.addShape(pres.ShapeType.rect, { x, y, w:4.6, h:0.55, fill:{color:s.col}, line:{type:"none"} });
    slide.addText(`${s.icon}  ${s.label}`, { x:x+0.1, y, w:4.4, h:0.55, fontSize:16, bold:true, color:WHITE, valign:"middle" });
    slide.addText(s.note, { x:x+0.15, y:y+0.65, w:4.3, h:1.0, fontSize:13, color:LIGHT_GRAY });
  });

  slide.addText("⚠ Warn patients about orange discolouration — it is harmless but alarming. Avoid soft contact lenses.", {
    x:0.3, y:5.4, w:9.4, h:0.2, fontSize:11, color:ACCENT2, italic:true, align:"center"
  });
}

// ====================================================
// SLIDE 12 – SUMMARY / QUICK REVISION
// ====================================================
{
  let slide = pres.addSlide();
  darkBg(slide);

  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:0.8, fill:{color:ACCENT1}, line:{type:"none"} });
  slide.addText("QUICK REVISION — Anti-TB Drugs at a Glance", {
    x:0.2, y:0, w:9.6, h:0.8,
    fontSize:20, bold:true, color:WHITE, align:"center", valign:"middle", margin:0
  });

  const summary = [
    { drug:"H (Isoniazid)",    highlight:"MOA: Inhibits Mycolic Acid (Kat G → Active → ⊖ ACP)", adr:"Peripheral Neuropathy (give B₆), Hepatotoxicity (fast acetylators), SLE-like" },
    { drug:"R (Rifampicin)",   highlight:"MOA: Inhibits RNA Polymerase (rpoB) → ⊖ Transcription", adr:"CYP inducer, Orange secretions, Hepatotoxicity, Pseudojaundice" },
    { drug:"Z (Pyrazinamide)", highlight:"Best sterilizing activity, acts on intracellular (slow) bacilli", adr:"Most hepatotoxic, Hyperuricaemia (gout), Avoid in pregnancy" },
    { drug:"E (Ethambutol)",   highlight:"Only bacteriostatic, targets both I/C and E/C bacilli", adr:"Retrobulbar Neuritis → visual colour defect (Red-Green), Safe in pregnancy" },
    { drug:"S (Streptomycin)", highlight:"Extracellular only, injectable aminoglycoside", adr:"Ototoxicity, Nephrotoxicity, C/I in Pregnancy" },
  ];

  summary.forEach((row, i) => {
    const y = 0.9 + i * 0.92;
    const bg = i%2===0?"162030":"1A2A3A";
    slide.addShape(pres.ShapeType.rect, { x:0.2, y, w:9.6, h:0.88, fill:{color:bg}, line:{type:"none"} });
    slide.addShape(pres.ShapeType.rect, { x:0.2, y:y+0.1, w:1.9, h:0.68, fill:{color:ACCENT1}, line:{type:"none"} });
    slide.addText(row.drug, { x:0.2, y:y+0.1, w:1.9, h:0.68, fontSize:12, bold:true, color:WHITE, align:"center", valign:"middle", margin:0 });
    slide.addText(row.highlight, { x:2.2, y:y+0.06, w:4.0, h:0.42, fontSize:11, bold:true, color:ACCENT2 });
    slide.addText("ADR: " + row.adr, { x:2.2, y:y+0.48, w:7.5, h:0.35, fontSize:10, color:LIGHT_GRAY });
  });
}

// ====================================================
// SLIDE 13 – FINAL / THANK YOU
// ====================================================
{
  let slide = pres.addSlide();
  darkBg(slide);

  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:0.18, h:5.625, fill:{color:ACCENT1}, line:{type:"none"} });
  slide.addShape(pres.ShapeType.rect, { x:0.18, y:0, w:0.08, h:5.625, fill:{color:ACCENT2}, line:{type:"none"} });
  slide.addShape(pres.ShapeType.rect, { x:0, y:4.9, w:10, h:0.725, fill:{color:ACCENT3}, line:{type:"none"} });

  slide.addText("THANK YOU", {
    x:0.5, y:1.0, w:9, h:1.2,
    fontSize:54, bold:true, color:WHITE, align:"center", charSpacing:10
  });
  slide.addText("Master Anti-TB Pharmacology with Cerebellum", {
    x:0.5, y:2.3, w:9, h:0.55,
    fontSize:20, color:ACCENT2, align:"center", italic:true
  });
  slide.addShape(pres.ShapeType.line, { x:1, y:3.0, w:8, h:0, line:{color:ACCENT1,width:2} });
  slide.addText([
    { text:"Key Takeaways:\n", options:{bold:true, color:ACCENT2, breakLine:true} },
    { text:"• HRZE = 1st Line oral drugs   •  S = Streptomycin (inject)   •  Z = Best sterilizing\n", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"• H MOA = Mycolic Acid inhibition   •  R MOA = RNA Polymerase inhibition\n", options:{color:LIGHT_GRAY, breakLine:true} },
    { text:"• INH → B6 deficiency → PN   •  Rifampicin → Orange secretions + CYP inducer", options:{color:LIGHT_GRAY} }
  ], { x:0.8, y:3.1, w:8.4, h:1.65, fontSize:13 });

  slide.addText("Cerebellum | Get the Balance Right", {
    x:0, y:4.9, w:10, h:0.725,
    fontSize:14, color:WHITE, align:"center", valign:"middle", bold:true, margin:0
  });
}

// ─── Write file ──────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/tb-pharmacology-ppt/Anti_TB_Drugs_Pharmacology.pptx" })
  .then(() => console.log("SUCCESS: PPT written"))
  .catch(e => { console.error("ERROR:", e); process.exit(1); });

cd /home/daytona/workspace/tb-pharmacology-ppt && node build.js 2>&1

ls -lh /home/daytona/workspace/tb-pharmacology-ppt/

~/tb-pharmacology-ppt/build2.js

const pptxgen = require("pptxgenjs");
const { execSync } = require("child_process");

// Download the 10 lecture images
const imageUrls = [
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/113937-1783521389200-cqghg4.jpg",  // 0: Rifampicin Other Uses
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/114178-1783521401379-hg0fcx.jpg",  // 1: Z & E ADRs
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/114179-1783521404272-zlavhh.jpg",  // 2: Streptomycin
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/114180-1783521405418-pe1gmn.jpg",  // 3: 2nd Line Cidal
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/114181-1783521406228-yh0ij7.jpg",  // 4: 2nd Line Static
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/114182-1783521410389-pdx8a0.jpg",  // 5: New Drugs
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/114183-1783521411498-vxnkcq.jpg",  // 6: Treatment NTEP
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/114184-1783521412257-o1m8ly.jpg",  // 7: Resistance Classification
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/114185-1783521413505-sed50q.jpg",  // 8: H-Resistant TB
  "https://d361swluvexzqs.cloudfront.net/chats-attachments/114186-1783521414154-r8pz8r.jpg",  // 9: Groups for DR-TB
];

console.log("Fetching images...");
const fetchCmd = `node /home/daytona/skills/shared/scripts/fetch_images.js ${imageUrls.map(u => `"${u}"`).join(" ")}`;
const imagesRaw = execSync(fetchCmd, { maxBuffer: 60 * 1024 * 1024 }).toString();
const images = JSON.parse(imagesRaw);
console.log(`Fetched ${images.length} images, errors: ${images.filter(i=>i.error).length}`);

// ─── Palette ─────────────────────────────────────────────────────
const DARK_BG    = "0D1B2A";
const MID_BG     = "132237";
const ACCENT1    = "E63946";   // red
const ACCENT2    = "F4A261";   // amber
const ACCENT3    = "2A9D8F";   // teal
const WHITE      = "FFFFFF";
const LIGHT_GRAY = "C8D8E8";
const YELLOW     = "FFD60A";
const PURPLE     = "C77DFF";
const GREEN      = "57CC99";
const DARK_CARD  = "162030";

let pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.author  = "Cerebellum | Get the Balance Right";
pres.title   = "Anti-TB Drugs – Part 2 (2nd Line, Treatment & Resistance)";

// ─── Helpers ─────────────────────────────────────────────────────
function darkBg(s) { s.background = { color: DARK_BG }; }
function midBg(s)  { s.background = { color: MID_BG  }; }

function topBar(slide, text, color) {
  slide.addShape(pres.ShapeType.rect, { x:0, y:0, w:10, h:0.72, fill:{color: color||ACCENT1}, line:{type:"none"} });
  slide.addText(text, { x:0.25, y:0, w:9.5, h:0.72, fontSize:21, bold:true, color:WHITE, valign:"middle", margin:0 });
}

function card(slide, x, y, w, h, borderColor, bgColor) {
  slide.addShape(pres.ShapeType.rect, { x, y, w, h, fill:{color: bgColor||DARK_CARD}, line:{color:borderColor||ACCENT1, width:2} });
}

// ====================================================
// SLIDE 1 – TITLE
// ====================================================
{
  let s = pres.addSlide();
  darkBg(s);
  s.addShape(pres.ShapeType.rect, { x:0,y:0,w:0.18,h:5.625, fill:{color:ACCENT1}, line:{type:"none"} });
  s.addShape(pres.ShapeType.rect, { x:0.18,y:0,w:0.08,h:5.625, fill:{color:ACCENT2}, line:{type:"none"} });
  s.addShape(pres.ShapeType.rect, { x:0,y:4.9,w:10,h:0.725, fill:{color:ACCENT3}, line:{type:"none"} });

  s.addText("ANTI-TB DRUGS", {
    x:0.5,y:0.65,w:9,h:1.1,
    fontSize:50,bold:true,color:WHITE,align:"center",charSpacing:6
  });
  s.addText("Part 2 — 2nd Line Drugs, New Drugs, Treatment & Drug Resistance", {
    x:0.5,y:1.82,w:9,h:0.6,
    fontSize:19,color:ACCENT2,align:"center",italic:true
  });
  s.addShape(pres.ShapeType.line, {x:1,y:2.55,w:8,h:0,line:{color:ACCENT1,width:2}});

  s.addText([
    { text:"Topics Covered:", options:{bold:true,color:ACCENT2,breakLine:true} },
    { text:"• Rifampicin Other Uses  • Pyrazinamide & Ethambutol ADRs  • Streptomycin\n", options:{color:LIGHT_GRAY,breakLine:true} },
    { text:"• 2nd Line Cidal & Static Drugs  • New Drugs (BPaL)  • NTEP Treatment Protocol", options:{color:LIGHT_GRAY,breakLine:true} },
    { text:"• Drug Resistance Classification  • H-Resistant TB  • Groups for DR-TB", options:{color:LIGHT_GRAY} },
  ], { x:0.6,y:2.7,w:8.8,h:2.0,fontSize:14 });

  s.addText("Cerebellum | Get the Balance Right", {
    x:0,y:4.9,w:10,h:0.725,
    fontSize:14,color:WHITE,align:"center",valign:"middle",bold:true,margin:0
  });
}

// ====================================================
// SLIDE 2 – RIFAMPICIN: OTHER USES
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 1 — Rifampicin (R): Other Clinical Uses", ACCENT2);

  // heading label
  s.addShape(pres.ShapeType.roundRect, {x:0.25,y:0.85,w:1.8,h:0.52, fill:{color:ACCENT2}, line:{type:"none"}, rectRadius:0.1});
  s.addText("e) Other Uses", {x:0.25,y:0.85,w:1.8,h:0.52, fontSize:14,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  const uses = [
    { icon:"★", head:"Leprosy",   body:"Rifampicin is a key component of Multi-Drug Therapy (MDT) for leprosy.", col:GREEN },
    { icon:"★", head:"Meningococcal Prophylaxis (M.Mo)",
      body:"Was previously DOC; now replaced by Ciprofloxacin for meningococcal prophylaxis.", col:ACCENT2 },
    { icon:"★", head:"Brucellosis — DOC",
      body:"DOC: Doxycycline + Rifampicin (Doxy + R) — combination therapy for brucellosis.", col:ACCENT1 },
    { icon:"★", head:"Gram +ve: MRSA",
      body:"Active against MRSA infections (Gram positive). Used in combination.", col:PURPLE },
    { icon:"★", head:"Gram -ve: Pseudomonas  ✗ Vancomycin",
      body:"Rifampicin active in Gram -ve (Pseudomonas). Vancomycin NOT effective against Gram -ve.", col:ACCENT3 },
  ];

  uses.forEach((u,i) => {
    const y = 1.5 + i*0.78;
    s.addShape(pres.ShapeType.rect, {x:0.2,y,w:0.38,h:0.62, fill:{color:u.col}, line:{type:"none"}});
    s.addText(u.icon, {x:0.2,y,w:0.38,h:0.62, fontSize:18,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
    s.addShape(pres.ShapeType.rect, {x:0.58,y,w:9.2,h:0.62, fill:{color:DARK_CARD}, line:{color:u.col,width:1.5}});
    s.addText(u.head, {x:0.68,y:y+0.02,w:9.0,h:0.3, fontSize:13,bold:true,color:u.col});
    s.addText(u.body, {x:0.68,y:y+0.32,w:9.0,h:0.28, fontSize:11,color:LIGHT_GRAY});
  });

  // MRSA alternate box
  card(s, 0.2, 5.1, 9.6, 0.42, ACCENT1, "0A1520");
  s.addText("MRSA Alternatives: a) Vancomycin  b) Teicoplanin  c) Cefepime  d) Rifampicin (Rcin)", {
    x:0.35,y:5.13,w:9.3,h:0.38, fontSize:12,bold:true,color:ACCENT1,valign:"middle"
  });
}

// ====================================================
// SLIDE 3 – PYRAZINAMIDE (Z) & ETHAMBUTOL (E)
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 2 — Pyrazinamide (Z) & Ethambutol (E): Properties & Adverse Effects", PURPLE);

  // ── Z section ──
  s.addShape(pres.ShapeType.rect, {x:0.2,y:0.85,w:0.7,h:3.1, fill:{color:PURPLE}, line:{type:"none"}});
  s.addText("③ Z", {x:0.2,y:0.85,w:0.7,h:3.1, fontSize:20,bold:true,color:WHITE,align:"center",valign:"middle",rotate:0});

  card(s, 0.9, 0.85, 4.2, 3.1, PURPLE);
  s.addText("Pyrazinamide (Z)", {x:1.0,y:0.9,w:4.0,h:0.45, fontSize:16,bold:true,color:PURPLE});
  s.addText([
    {text:"• Bactericidal\n", options:{color:GREEN,bold:true,breakLine:true}},
    {text:"• Intracellular (I/C) → Best Sterilizing Activity\n", options:{color:LIGHT_GRAY,breakLine:true}},
    {text:"• Hepatotoxic — Maximum (most of all TB drugs)\n", options:{color:ACCENT1,bold:true,breakLine:true}},
    {text:"• ↑ Uric Acid (Hyperuricaemia) — Key Side Effect → Gout\n", options:{color:ACCENT2,bold:true,breakLine:true}},
    {text:"• Avoid in Pregnancy", options:{color:ACCENT1}},
  ], {x:1.0,y:1.42,w:4.0,h:2.3, fontSize:12});

  // Uric Acid badge
  s.addShape(pres.ShapeType.rect, {x:1.5,y:3.1,w:3.0,h:0.5, fill:{color:ACCENT2}, line:{type:"none"}});
  s.addText("⚠ ↑ Uric Acid → Gout (Main SE)", {x:1.5,y:3.1,w:3.0,h:0.5, fontSize:13,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  // ── E section ──
  s.addShape(pres.ShapeType.rect, {x:5.5,y:0.85,w:0.7,h:3.1, fill:{color:ACCENT3}, line:{type:"none"}});
  s.addText("④ E", {x:5.5,y:0.85,w:0.7,h:3.1, fontSize:20,bold:true,color:WHITE,align:"center",valign:"middle"});

  card(s, 6.2, 0.85, 3.6, 3.1, ACCENT3);
  s.addText("Ethambutol (E)", {x:6.3,y:0.9,w:3.4,h:0.45, fontSize:16,bold:true,color:ACCENT3});
  s.addText([
    {text:"• Bacteriostatic (STATIC)\n", options:{color:ACCENT2,bold:true,breakLine:true}},
    {text:"• NOT Hepatotoxic ✗\n", options:{color:GREEN,breakLine:true}},
    {text:"• Safe in Pregnancy ✓\n", options:{color:GREEN,breakLine:true}},
    {text:"\nEye (ADR): Optic Neuritis\n", options:{color:ACCENT1,bold:true,breakLine:true}},
    {text:"→ Red-Green Colour Blindness\n", options:{color:ACCENT1,breakLine:true}},
    {text:"→ C/I in Children < 6 yrs\n  (cannot report visual symptoms)", options:{color:LIGHT_GRAY}},
  ], {x:6.3,y:1.42,w:3.4,h:2.3, fontSize:12});

  // Eye badge
  s.addShape(pres.ShapeType.rect, {x:6.0,y:3.1,w:3.6,h:0.5, fill:{color:ACCENT1}, line:{type:"none"}});
  s.addText("⚠ Optic Neuritis → Red-Green Blindness", {x:6.0,y:3.1,w:3.6,h:0.5, fontSize:12,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  s.addText("★ Z = Most Hepatotoxic of ALL TB drugs   |   ★ E = Only Bacteriostatic 1st Line drug — Causes Optic Neuritis", {
    x:0.2,y:3.78,w:9.6,h:0.38, fontSize:12,bold:true,color:YELLOW,align:"center"
  });

  // Lecture image strip at bottom
  if (!images[1].error) {
    s.addImage({ data: images[1].base64, x:0.2, y:4.2, w:4.0, h:1.3 });
  }
  if (!images[0].error) {
    s.addImage({ data: images[0].base64, x:5.0, y:4.2, w:4.8, h:1.3 });
  }
}

// ====================================================
// SLIDE 4 – STREPTOMYCIN (S)
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 3 — Streptomycin (S): Properties & Adverse Effects", ACCENT1);

  s.addShape(pres.ShapeType.rect, {x:0.2,y:0.85,w:0.7,h:4.2, fill:{color:ACCENT1}, line:{type:"none"}});
  s.addText("⑤ S", {x:0.2,y:0.85,w:0.7,h:4.2, fontSize:20,bold:true,color:WHITE,align:"center",valign:"middle"});

  // Properties cards
  const props = [
    { label:"Route",        val:"Injection – IM (Intramuscular) only",               col:ACCENT2 },
    { label:"Activity",     val:"BACTERICIDAL",                                       col:GREEN },
    { label:"Location",     val:"Extracellular (E/C) only",                           col:ACCENT3 },
    { label:"Hepatotoxic",  val:"NOT hepatotoxic ✗",                                  col:GREEN },
    { label:"Nephrotoxic",  val:"Yes — Nephrotoxicity is the key ADR ✓",              col:ACCENT1 },
    { label:"Pregnancy",    val:"CONTRAINDICATED (C/I) — causes fetal ototoxicity",   col:ACCENT1 },
  ];

  props.forEach((p, i) => {
    const y = 0.9 + i * 0.64;
    s.addShape(pres.ShapeType.rect, {x:0.95,y,w:2.0,h:0.56, fill:{color:p.col}, line:{type:"none"}});
    s.addText(p.label, {x:0.95,y,w:2.0,h:0.56, fontSize:13,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
    s.addShape(pres.ShapeType.rect, {x:2.95,y,w:6.8,h:0.56, fill:{color:DARK_CARD}, line:{color:p.col,width:1.5}});
    s.addText(p.val, {x:3.05,y:y+0.04,w:6.6,h:0.48, fontSize:13,color:LIGHT_GRAY,valign:"middle"});
  });

  // Key note
  s.addShape(pres.ShapeType.rect, {x:0.2,y:4.92,w:9.6,h:0.55, fill:{color:"0A1520"}, line:{color:ACCENT1,width:2}});
  s.addText("★ Streptomycin: the ONLY non-oral 1st Line drug | C/I in Pregnancy | Nephrotoxic | Extracellular only", {
    x:0.3,y:4.95,w:9.4,h:0.5, fontSize:12,bold:true,color:ACCENT2,valign:"middle"
  });
}

// ====================================================
// SLIDE 5 – 2ND LINE DRUGS: CIDAL GROUP
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 4 — 2nd Line Drugs: Group ① CIDAL (Fluoroquinolones + Injectables)", ACCENT3);

  s.addText("2nd Line Drugs — Used in Drug-Resistant TB (MDR / XDR)", {
    x:0.2,y:0.82,w:9.6,h:0.42, fontSize:14,color:ACCENT2,align:"center",italic:true
  });

  // FQ column
  card(s, 0.2, 1.32, 4.5, 3.2, ACCENT3);
  s.addShape(pres.ShapeType.rect, {x:0.2,y:1.32,w:4.5,h:0.5, fill:{color:ACCENT3}, line:{type:"none"}});
  s.addText("a) Fluoroquinolones (FQ)", {x:0.2,y:1.32,w:4.5,h:0.5, fontSize:15,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  const fqs = [
    { name:"Ofloxacin",    note:"Not recommended ✗", col:ACCENT1 },
    { name:"Moxifloxacin", note:"Preferred ✓",       col:GREEN },
    { name:"Gatifloxacin", note:"Not recommended ✗", col:ACCENT1 },
    { name:"Levofloxacin", note:"Preferred ✓",       col:GREEN },
  ];
  fqs.forEach((f,i) => {
    const y = 1.92 + i*0.56;
    s.addShape(pres.ShapeType.roundRect, {x:0.4,y,w:2.3,h:0.48, fill:{color:"1A2A3A"}, line:{color:f.col,width:1.5}, rectRadius:0.1});
    s.addText(f.name, {x:0.4,y,w:2.3,h:0.48, fontSize:13,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
    s.addShape(pres.ShapeType.roundRect, {x:2.8,y,w:1.7,h:0.48, fill:{color:f.col}, line:{type:"none"}, rectRadius:0.1});
    s.addText(f.note, {x:2.8,y,w:1.7,h:0.48, fontSize:12,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
  });

  s.addText("XDR-TB: FQ resistance is defining criterion", {
    x:0.3,y:4.05,w:4.2,h:0.38, fontSize:11,color:YELLOW,italic:true
  });

  // Injectable column
  card(s, 5.0, 1.32, 4.8, 3.2, ACCENT2);
  s.addShape(pres.ShapeType.rect, {x:5.0,y:1.32,w:4.8,h:0.5, fill:{color:ACCENT2}, line:{type:"none"}});
  s.addText("b) Injectables (IM)", {x:5.0,y:1.32,w:4.8,h:0.5, fontSize:15,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  const injs = [
    { name:"Streptomycin",  note:"Safe in pregnancy ✓", col:GREEN  },
    { name:"Capreomycin",   note:"C/I pregnancy ✗",     col:ACCENT1},
    { name:"Kanamycin",     note:"C/I pregnancy ✗",     col:ACCENT1},
    { name:"Amikacin",      note:"Safe ✓",              col:GREEN  },
  ];
  injs.forEach((inj,i) => {
    const y = 1.92 + i*0.56;
    s.addShape(pres.ShapeType.roundRect, {x:5.15,y,w:2.5,h:0.48, fill:{color:"1A2A3A"}, line:{color:inj.col,width:1.5}, rectRadius:0.1});
    s.addText(inj.name, {x:5.15,y,w:2.5,h:0.48, fontSize:13,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
    s.addShape(pres.ShapeType.roundRect, {x:7.75,y,w:1.9,h:0.48, fill:{color:inj.col}, line:{type:"none"}, rectRadius:0.1});
    s.addText(inj.note, {x:7.75,y,w:1.9,h:0.48, fontSize:11,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
  });

  // Pregnancy note
  s.addShape(pres.ShapeType.rect, {x:5.15,y:4.05,w:3.5,h:0.38, fill:{color:ACCENT1}, line:{type:"none"}});
  s.addText("All injectables: C/I in Pregnancy (except Streptomycin)", {x:5.15,y:4.05,w:3.5,h:0.38, fontSize:10,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  s.addShape(pres.ShapeType.rect, {x:0.2,y:4.6,w:9.6,h:0.85, fill:{color:"0A1520"}, line:{color:ACCENT3,width:2}});
  s.addText("All 2nd Line Cidal drugs are ALL BACTERICIDAL.\nPreferred FQ: Moxifloxacin & Levofloxacin | XDR-TB = Resistance to H+R + FQ", {
    x:0.35,y:4.63,w:9.3,h:0.8, fontSize:12,color:ACCENT2
  });
}

// ====================================================
// SLIDE 6 – 2ND LINE DRUGS: STATIC GROUP + HEPATOTOXIC ADES
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 5 — 2nd Line Drugs: Group ② STATIC + Hepatotoxic ADEs", PURPLE);

  // Hepatotoxic ADE column (left)
  card(s, 0.2, 0.82, 2.8, 2.5, ACCENT1);
  s.addShape(pres.ShapeType.rect, {x:0.2,y:0.82,w:2.8,h:0.5, fill:{color:ACCENT1}, line:{type:"none"}});
  s.addText("Hepatotoxic ADEs", {x:0.2,y:0.82,w:2.8,h:0.5, fontSize:14,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
  const hepa = ["a) H (Isoniazid)", "b) R (Rifampicin)", "c) Ethionamide ✓", "d) S (Streptomycin) — in box"];
  hepa.forEach((h,i) => {
    s.addText(h, {x:0.35,y:1.42+i*0.44,w:2.5,h:0.4, fontSize:12,color: i===2?ACCENT2:(i===3?ACCENT1:LIGHT_GRAY)});
  });

  // Static Group (a) — right
  card(s, 3.2, 0.82, 6.6, 2.5, PURPLE);
  s.addShape(pres.ShapeType.rect, {x:3.2,y:0.82,w:6.6,h:0.5, fill:{color:PURPLE}, line:{type:"none"}});
  s.addText("② Static Group — (a) Oral Agents", {x:3.2,y:0.82,w:6.6,h:0.5, fontSize:14,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  const staticA = [
    { drug:"Cycloserine",    adr:"Psychosis / CNS toxicity",          col:ACCENT1 },
    { drug:"Ethionamide",    adr:"Hepatotoxic + Hypothyroidism",      col:ACCENT1 },
    { drug:"PAS",            adr:"Hepatotoxic",                       col:ACCENT2 },
    { drug:"Thioacetazone",  adr:"HIV ✗✗ (Steven-Johnson Syndrome)",  col:"CC0000" },
  ];
  staticA.forEach((d,i) => {
    const y = 1.42+i*0.44;
    s.addShape(pres.ShapeType.roundRect, {x:3.3,y,w:2.2,h:0.38, fill:{color:"1A2A3A"}, line:{color:d.col,width:1.5}, rectRadius:0.1});
    s.addText(d.drug, {x:3.3,y,w:2.2,h:0.38, fontSize:12,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
    s.addShape(pres.ShapeType.line, {x:5.52,y:y+0.19,w:0.25,h:0, line:{color:d.col,width:1.5}});
    s.addText(d.adr, {x:5.8,y,w:3.8,h:0.38, fontSize:11,color:d.col,valign:"middle"});
  });

  // Static Group (b) — Linezolide + Clofazimine
  card(s, 0.2, 3.45, 9.6, 1.65, ACCENT3);
  s.addShape(pres.ShapeType.rect, {x:0.2,y:3.45,w:9.6,h:0.5, fill:{color:ACCENT3}, line:{type:"none"}});
  s.addText("② Static Group — (b) Special Purpose Agents", {x:0.2,y:3.45,w:9.6,h:0.5, fontSize:14,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  const specialDrugs = [
    { drug:"Linezolide",    use:"DOC for VRSA Pneumonia",  col:YELLOW },
    { drug:"Clofazimine",   use:"Leprosy treatment",       col:GREEN  },
  ];
  specialDrugs.forEach((d,i) => {
    const x = i===0 ? 0.5 : 5.2;
    card(s, x, 4.0, 4.3, 1.0, d.col);
    s.addText(d.drug, {x:x+0.15,y:4.05,w:4.0,h:0.42, fontSize:16,bold:true,color:d.col});
    s.addText("Use: "+d.use, {x:x+0.15,y:4.5,w:4.0,h:0.42, fontSize:13,color:LIGHT_GRAY});
  });
}

// ====================================================
// SLIDE 7 – NEW DRUGS (BEDAQUILINE, PRETOMANID, DELAMANID)
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 6 — New Anti-TB Drugs: Bedaquiline, Pretomanid & Delamanid", GREEN);

  s.addText("③ New Drugs — All BACTERICIDAL", {
    x:0.2,y:0.85,w:9.6,h:0.45, fontSize:16,bold:true,color:GREEN,align:"center"
  });

  // Drug trio
  const newDrugs = [
    { name:"Bedaquiline",  col:PURPLE },
    { name:"Pretomanid",   col:ACCENT2 },
    { name:"Delamanid",    col:ACCENT3 },
  ];
  newDrugs.forEach((d,i) => {
    const x = 0.2 + i*3.25;
    card(s, x, 1.4, 3.0, 0.75, d.col);
    s.addText(d.name, {x:x+0.1,y:1.4,w:2.8,h:0.75, fontSize:16,bold:true,color:d.col,align:"center",valign:"middle"});
  });

  s.addShape(pres.ShapeType.line, {x:1.7,y:2.15,w:0,h:0.4, line:{color:PURPLE,width:2}});
  s.addShape(pres.ShapeType.line, {x:4.95,y:2.15,w:0,h:0.4, line:{color:ACCENT2,width:2}});
  s.addShape(pres.ShapeType.line, {x:8.2,y:2.15,w:0,h:0.4, line:{color:ACCENT3,width:2}});

  // MOA section
  card(s, 0.2, 2.55, 9.6, 2.55, YELLOW, "0A1520");
  s.addShape(pres.ShapeType.rect, {x:0.2,y:2.55,w:9.6,h:0.48, fill:{color:"1A2A3A"}, line:{type:"none"}});
  s.addText("Mechanisms of Action (MOA)", {x:0.2,y:2.55,w:9.6,h:0.48, fontSize:15,bold:true,color:YELLOW,align:"center",valign:"middle",margin:0});

  s.addShape(pres.ShapeType.roundRect, {x:0.4,y:3.1,w:4.4,h:0.8, fill:{color:DARK_CARD}, line:{color:PURPLE,width:2}, rectRadius:0.1});
  s.addText([
    {text:"Bedaquiline\n", options:{bold:true,color:PURPLE,breakLine:true}},
    {text:"⊖ ATP Synthase → Blocks energy production", options:{color:LIGHT_GRAY}},
  ], {x:0.5,y:3.12,w:4.2,h:0.76, fontSize:13,valign:"top"});

  s.addShape(pres.ShapeType.roundRect, {x:5.0,y:3.1,w:4.6,h:0.8, fill:{color:DARK_CARD}, line:{color:ACCENT2,width:2}, rectRadius:0.1});
  s.addText([
    {text:"Pretomanid & Delamanid\n", options:{bold:true,color:ACCENT2,breakLine:true}},
    {text:"⊖ Mycolic Acid + Generates toxic NO (nitric oxide)", options:{color:LIGHT_GRAY}},
  ], {x:5.1,y:3.12,w:4.4,h:0.76, fontSize:13,valign:"top"});

  // ADR: QT prolongation
  s.addShape(pres.ShapeType.rect, {x:0.2,y:4.05,w:9.6,h:0.75, fill:{color:ACCENT1}, line:{type:"none"}});
  s.addText("⚠ Key ADR: ↑ QT Prolongation — Risk of fatal arrhythmias (monitor ECG)", {
    x:0.3,y:4.08,w:9.4,h:0.7, fontSize:15,bold:true,color:WHITE,align:"center",valign:"middle",margin:0
  });

  s.addShape(pres.ShapeType.rect, {x:0.2,y:4.88,w:9.6,h:0.6, fill:{color:"0A1520"}, line:{color:GREEN,width:2}});
  s.addText("These are used for MDR-TB & XDR-TB. BPaL regimen = Bedaquiline + Pretomanid + Linezolid", {
    x:0.3,y:4.9,w:9.4,h:0.56, fontSize:12,bold:true,color:GREEN,align:"center",valign:"middle"
  });
}

// ====================================================
// SLIDE 8 – TB TREATMENT: NTEP PROTOCOL
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 7 — TB Treatment: NTEP Protocol (National TB Elimination Programme)", ACCENT2);

  // NTEP box
  s.addShape(pres.ShapeType.rect, {x:3.5,y:0.88,w:3,h:0.6, fill:{color:ACCENT1}, line:{type:"none"}});
  s.addText("NTEP", {x:3.5,y:0.88,w:3,h:0.6, fontSize:22,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  // Two branches
  s.addShape(pres.ShapeType.line, {x:3.5,y:1.18,w:-1.2,h:0, line:{color:WHITE,width:2}});
  s.addShape(pres.ShapeType.line, {x:6.5,y:1.18,w:1.2,h:0, line:{color:WHITE,width:2}});

  // Drug Sensitive (left)
  card(s, 0.2, 1.55, 4.5, 3.65, ACCENT3, "0A1520");
  s.addShape(pres.ShapeType.rect, {x:0.2,y:1.55,w:4.5,h:0.52, fill:{color:ACCENT3}, line:{type:"none"}});
  s.addText("Drug Sensitive TB", {x:0.2,y:1.55,w:4.5,h:0.52, fontSize:15,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  s.addText("Standard 6-Month Regimen:", {x:0.35,y:2.15,w:4.2,h:0.38, fontSize:13,bold:true,color:ACCENT2});

  // IP box
  s.addShape(pres.ShapeType.rect, {x:0.35,y:2.6,w:1.0,h:0.7, fill:{color:ACCENT1}, line:{type:"none"}});
  s.addText("IP", {x:0.35,y:2.6,w:1.0,h:0.7, fontSize:18,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
  s.addShape(pres.ShapeType.rect, {x:1.4,y:2.6,w:3.1,h:0.7, fill:{color:DARK_CARD}, line:{color:ACCENT1,width:2}});
  s.addText("2 months HRZE", {x:1.4,y:2.6,w:3.1,h:0.7, fontSize:16,bold:true,color:ACCENT1,align:"center",valign:"middle"});

  // CP box
  s.addShape(pres.ShapeType.rect, {x:0.35,y:3.42,w:1.0,h:0.7, fill:{color:PURPLE}, line:{type:"none"}});
  s.addText("CP", {x:0.35,y:3.42,w:1.0,h:0.7, fontSize:18,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
  s.addShape(pres.ShapeType.rect, {x:1.4,y:3.42,w:3.1,h:0.7, fill:{color:DARK_CARD}, line:{color:PURPLE,width:2}});
  s.addText("4 months HRE", {x:1.4,y:3.42,w:3.1,h:0.7, fontSize:16,bold:true,color:PURPLE,align:"center",valign:"middle"});

  s.addText("IP = Intensive Phase (first 2 months)\nCP = Continuation Phase (next 4 months)", {
    x:0.35,y:4.2,w:4.2,h:0.7, fontSize:11,color:LIGHT_GRAY
  });

  // Drug Resistant (right)
  card(s, 5.1, 1.55, 4.7, 3.65, ACCENT1, "0A1520");
  s.addShape(pres.ShapeType.rect, {x:5.1,y:1.55,w:4.7,h:0.52, fill:{color:ACCENT1}, line:{type:"none"}});
  s.addText("Drug Resistant TB", {x:5.1,y:1.55,w:4.7,h:0.52, fontSize:15,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  const drTypes = [
    { label:"Mono-drug R",    body:"Resistant to ONE drug (H/Z/E)", col:ACCENT2 },
    { label:"Poly-drug R",    body:"Resistant to >1 drug",          col:ACCENT2 },
    { label:"MDR-TB",         body:"H + R resistance",              col:ACCENT1 },
    { label:"Pre-XDR",        body:"H+R + FQ resistance",           col:PURPLE  },
    { label:"XDR-TB",         body:"H+R + FQ + injectable",         col:"CC0000"},
  ];
  drTypes.forEach((t,i) => {
    const y = 2.15+i*0.56;
    s.addShape(pres.ShapeType.roundRect, {x:5.2,y,w:2.0,h:0.48, fill:{color:t.col}, line:{type:"none"}, rectRadius:0.1});
    s.addText(t.label, {x:5.2,y,w:2.0,h:0.48, fontSize:11,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
    s.addText(t.body, {x:7.3,y:y+0.04,w:2.3,h:0.4, fontSize:11,color:LIGHT_GRAY,valign:"middle"});
  });

  s.addShape(pres.ShapeType.rect, {x:0.2,y:5.28,w:9.6,h:0.3, fill:{color:"0A1520"}, line:{type:"none"}});
  s.addText("Total Duration: 6 months (Drug Sensitive) | 9-20 months (MDR/XDR depending on regimen)", {
    x:0.3,y:5.28,w:9.4,h:0.3, fontSize:11,color:ACCENT2,align:"center"
  });
}

// ====================================================
// SLIDE 9 – DRUG RESISTANCE CLASSIFICATION
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 8 — Drug Resistance Classification & Treatment Regimens", ACCENT1);

  s.addText("Classification of TB Drug Resistance", {
    x:0.2,y:0.82,w:9.6,h:0.42, fontSize:15,bold:true,color:ACCENT2,align:"center"
  });

  const classifs = [
    { num:"1", type:"Mono-drug Resistance",    def:"Resistant to ONE drug: H, Z, or E",             reg:"Adjust regimen — replace the resistant drug",                   col:GREEN   },
    { num:"2", type:"Poly-drug Resistance",    def:"Resistant to >1 drug (but not H+R together)",   reg:"Adjust regimen based on DST",                                   col:ACCENT2 },
    { num:"3", type:"Rifampicin Resistance (RR)", def:"Resistant to R but Sensitive to H",           reg:"Treat as MDR-TB",                                               col:ACCENT2 },
    { num:"4", type:"MDR-TB",                  def:"Resistant to BOTH H + R",                        reg:"H+R backbone + FQ (Moxifloxacin/Levofloxacin)",                col:ACCENT1 },
    { num:"5★","type":"Pre-XDR",               def:"H+R resistance + FQ resistance",                reg:"H+R + FQ + Bedaquiline or Linezolide",                          col:PURPLE  },
    { num:"6", type:"XDR-TB",                  def:"H+R + FQ + 2nd Line injectable resistance",     reg:"H+R + FQ + Bedaquiline or Linezolide (BPaL regimen)",           col:"CC0000" },
  ];

  classifs.forEach((c,i) => {
    const y = 1.35 + i*0.67;
    s.addShape(pres.ShapeType.rect, {x:0.2,y,w:0.65,h:0.6, fill:{color:c.col}, line:{type:"none"}});
    s.addText(c.num, {x:0.2,y,w:0.65,h:0.6, fontSize:16,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
    s.addShape(pres.ShapeType.rect, {x:0.85,y,w:9.0,h:0.6, fill:{color:i%2===0?DARK_CARD:"162840"}, line:{color:c.col,width:1.5}});
    s.addText(c.type, {x:0.95,y:y+0.02,w:2.4,h:0.3, fontSize:12,bold:true,color:c.col});
    s.addText(c.def, {x:0.95,y:y+0.32,w:2.4,h:0.26, fontSize:10,color:LIGHT_GRAY});
    s.addShape(pres.ShapeType.line, {x:3.42,y:y+0.08,w:0,h:0.44, line:{color:"2A3A4A",width:1}});
    s.addText("Regimen: "+c.reg, {x:3.55,y:y+0.06,w:6.15,h:0.5, fontSize:11,color:LIGHT_GRAY,valign:"middle"});
  });

  s.addText("★ Pre-XDR is a new WHO 2021 classification | XDR = Extensively Drug Resistant TB", {
    x:0.2,y:5.4,w:9.6,h:0.2, fontSize:10,color:ACCENT2,italic:true,align:"center"
  });
}

// ====================================================
// SLIDE 10 – H-RESISTANT TB REGIMEN
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 9 — H-Resistant TB: Treatment Regimen", ACCENT3);

  // H-resistant box
  s.addShape(pres.ShapeType.rect, {x:2.0,y:0.9,w:6,h:0.85, fill:{color:"0A1520"}, line:{color:ACCENT1,width:3}});
  s.addText("H-Resistant TB", {x:2.0,y:0.9,w:6,h:0.85, fontSize:26,bold:true,color:ACCENT1,align:"center",valign:"middle",margin:0});

  // Regimen
  s.addText("Treatment Regimen:", {x:0.5,y:2.0,w:9,h:0.48, fontSize:16,bold:true,color:ACCENT2,align:"center"});

  s.addShape(pres.ShapeType.rect, {x:1.0,y:2.58,w:8,h:1.1, fill:{color:"0A1520"}, line:{color:GREEN,width:3}});
  s.addText("6–9 RZE + Lf", {x:1.0,y:2.58,w:8,h:1.1, fontSize:36,bold:true,color:GREEN,align:"center",valign:"middle",margin:0});

  // Breakdown cards
  const regParts = [
    { abbr:"R",  full:"Rifampicin",    col:ACCENT2 },
    { abbr:"Z",  full:"Pyrazinamide",  col:PURPLE  },
    { abbr:"E",  full:"Ethambutol",    col:ACCENT3 },
    { abbr:"Lf", full:"Levofloxacin",  col:GREEN   },
  ];
  regParts.forEach((r,i) => {
    const x = 0.8 + i*2.1;
    s.addShape(pres.ShapeType.rect, {x,y:3.82,w:1.8,h:0.7, fill:{color:r.col}, line:{type:"none"}});
    s.addText(r.abbr, {x,y:3.82,w:1.8,h:0.4, fontSize:18,bold:true,color:WHITE,align:"center",valign:"bottom",margin:0});
    s.addText(r.full, {x,y:4.22,w:1.8,h:0.3, fontSize:11,color:WHITE,align:"center",valign:"top",margin:0});
  });

  s.addShape(pres.ShapeType.rect, {x:0.5,y:4.68,w:9,h:0.72, fill:{color:"0A1520"}, line:{color:ACCENT2,width:2}});
  s.addText([
    {text:"Duration: 6–9 months   ", options:{bold:true,color:ACCENT2}},
    {text:"H (Isoniazid) is dropped from the regimen since it is resistant.  ", options:{color:LIGHT_GRAY}},
    {text:"Lf = Levofloxacin added to compensate.", options:{color:GREEN}},
  ], {x:0.65,y:4.7,w:8.7,h:0.68, fontSize:12,valign:"middle"});
}

// ====================================================
// SLIDE 11 – GROUPS FOR DR-TB (A, B, C)
// ====================================================
{
  let s = pres.addSlide();
  midBg(s);
  topBar(s, "TOPIC 10 — WHO Groups for Drug-Resistant TB (DR-TB)", ACCENT2);

  s.addText("Drugs grouped by priority for MDR/XDR-TB regimen construction", {
    x:0.2,y:0.82,w:9.6,h:0.38, fontSize:13,color:LIGHT_GRAY,align:"center",italic:true
  });

  const groups = [
    {
      label:"Group A", sublabel:"Priority (Use ALL if possible)", col:GREEN,
      drugs:["Levofloxacin or Moxifloxacin", "Bedaquiline", "Linezolide"]
    },
    {
      label:"Group B", sublabel:"Add next", col:ACCENT2,
      drugs:["Clofazimine", "Cycloserine or Terizidone"]
    },
    {
      label:"Group C", sublabel:"Use when A & B insufficient", col:ACCENT1,
      drugs:["Z (Pyrazinamide)", "E (Ethambutol)", "Carbapenems", "Ethionamide", "PAS", "Delamanid", "Amikacin or Streptomycin"]
    },
  ];

  groups.forEach((g,i) => {
    const y = 1.3 + i*1.35;
    const h = g.drugs.length > 4 ? 1.25 : (g.drugs.length > 2 ? 1.1 : 0.95);
    s.addShape(pres.ShapeType.rect, {x:0.2,y,w:2.2,h, fill:{color:g.col}, line:{type:"none"}});
    s.addText(g.label, {x:0.2,y,w:2.2,h:0.55, fontSize:18,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
    s.addText(g.sublabel, {x:0.2,y:y+0.55,w:2.2,h:h-0.55, fontSize:10,color:WHITE,align:"center",valign:"top"});
    s.addShape(pres.ShapeType.rect, {x:2.4,y,w:7.4,h, fill:{color:DARK_CARD}, line:{color:g.col,width:2}});
    g.drugs.forEach((d,di) => {
      const dy = y + 0.12 + di*(h/g.drugs.length);
      s.addShape(pres.ShapeType.roundRect, {x:2.6,y:dy,w:0.3,h:0.28, fill:{color:g.col}, line:{type:"none"}, rectRadius:0.1});
      s.addText(d, {x:3.05,y:dy,w:6.5,h:0.28, fontSize:13,color:LIGHT_GRAY,valign:"middle"});
    });
  });

  s.addShape(pres.ShapeType.rect, {x:0.2,y:5.22,w:9.6,h:0.38, fill:{color:"0A1520"}, line:{color:ACCENT2,width:2}});
  s.addText("Group A drugs are CORE of MDR-TB regimen. Minimum 3 Group A+B drugs recommended by WHO 2022.", {
    x:0.3,y:5.24,w:9.4,h:0.34, fontSize:11,bold:true,color:ACCENT2,align:"center"
  });
}

// ====================================================
// SLIDE 12 – SUMMARY / THANK YOU
// ====================================================
{
  let s = pres.addSlide();
  darkBg(s);
  s.addShape(pres.ShapeType.rect, {x:0,y:0,w:10,h:0.75, fill:{color:ACCENT1}, line:{type:"none"}});
  s.addText("QUICK REVISION — Part 2 Summary", {x:0.2,y:0,w:9.6,h:0.75, fontSize:22,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});

  const summary = [
    { topic:"Rifampicin Other Uses", detail:"Leprosy ✓ | Was DOC M.Mo (now Cipro) | DOC Brucellosis: Doxy+R | MRSA ✓ | Not Pseudomonas", col:ACCENT2 },
    { topic:"Pyrazinamide (Z)",      detail:"Cidal | I/C | Best Sterilizing | Max Hepatotoxic | ↑Uric acid (Gout) | Avoid Pregnancy",        col:PURPLE },
    { topic:"Ethambutol (E)",        detail:"Static | Not Hepatotoxic | Optic Neuritis → Red-Green Colour Blindness | C/I < 6 yrs",           col:ACCENT3 },
    { topic:"Streptomycin (S)",      detail:"Injection IM | Cidal | E/C | Not Hepatotoxic | Nephrotoxic | C/I Pregnancy",                     col:ACCENT1 },
    { topic:"2nd Line Cidal",        detail:"FQ: Moxi ✓ Levo ✓ | Injectables: Strep ✓ Amikacin ✓ | All C/I in Pregnancy (except Strep)",     col:ACCENT3 },
    { topic:"New Drugs (BPaL)",      detail:"Bedaquiline (ATP ⊖) + Pretomanid/Delamanid (Mycolic ⊖, NO toxic) | ADR: ↑QT",                   col:GREEN   },
    { topic:"NTEP Treatment",        detail:"Drug Sensitive: IP=2HRZE | CP=4HRE | MDR: H+R+FQ | XDR: BPaL",                                  col:ACCENT2 },
    { topic:"H-Resistant TB",        detail:"Regimen: 6-9 RZE + Lf (Levofloxacin) — 6 to 9 months",                                          col:GREEN   },
  ];

  summary.forEach((r,i) => {
    const y = 0.85 + i*0.58;
    s.addShape(pres.ShapeType.rect, {x:0.2,y,w:9.6,h:0.54, fill:{color:i%2===0?DARK_CARD:"162030"}, line:{type:"none"}});
    s.addShape(pres.ShapeType.rect, {x:0.2,y:y+0.06,w:2.3,h:0.42, fill:{color:r.col}, line:{type:"none"}});
    s.addText(r.topic, {x:0.2,y:y+0.06,w:2.3,h:0.42, fontSize:11,bold:true,color:WHITE,align:"center",valign:"middle",margin:0});
    s.addText(r.detail, {x:2.6,y:y+0.06,w:7.1,h:0.42, fontSize:10,color:LIGHT_GRAY,valign:"middle"});
  });

  s.addShape(pres.ShapeType.rect, {x:0,y:5.35,w:10,h:0.275, fill:{color:ACCENT3}, line:{type:"none"}});
  s.addText("Cerebellum | Get the Balance Right", {x:0,y:5.35,w:10,h:0.275, fontSize:12,color:WHITE,align:"center",valign:"middle",bold:true,margin:0});
}

// ─── Write file ──────────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/tb-pharmacology-ppt/Anti_TB_Drugs_Part2.pptx" })
  .then(() => console.log("SUCCESS: PPT written"))
  .catch(e => { console.error("ERROR:", e); process.exit(1); });

cd /home/daytona/workspace/tb-pharmacology-ppt && node build2.js 2>&1

ls -lh /home/daytona/workspace/tb-pharmacology-ppt/