60 years old female, is a known HT and DM for the past 20 years has been admitted with the C/o progressive swelling in the face, abdomen and legs for the past 3 months a) What is your diagnosis. b) Classify diuretics. c) Describe the mechanism of action, uses and adverse effects of high ceiling diuretics. d) Justify the rationality in combining high ceiling diuretics with ACE inhibitors.

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