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screening of antianginal drugs 50 slide conetnt

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screening of antianginal drugs experimental methods preclinical models pithed rat isoprenaline

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screening methods antianginal drugs in vivo in vitro models procedure principle

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Your 50-slide presentation is ready:

Screening of Antianginal Drugs

Presentation · PPTX

 (1.1 MB)

What's inside (50 slides, 8 sections)

SectionSlidesContent
01 – Introduction1-7Title, Outline, Definition, Types of angina (stable/variant/unstable/microvascular), Pathophysiology, O2 supply-demand, Coronary blood flow & ischemia cascade
02 – Classification8-10Full drug classification (nitrates, beta blockers, CCBs, newer drugs), Drug targets table
03 – Mechanisms of Action11-18Organic nitrates (NO → cGMP pathway), Nitrate preparations comparison table, Tolerance & adverse effects, Beta blockers, CCBs (DHP vs. non-DHP)
04 – Newer Drugs19-23Ranolazine (late INa blocker), Ivabradine, Nicorandil, Trimetazidine/Perhexiline, Investigational agents table
05 – In Vivo Screening24-31Overview, Isoproterenol-induced necrosis, LAD coronary artery occlusion-reperfusion, Preconditioning model (rabbit), Microspheres model, Electrical stimulation thrombosis, Pithed rat preparation
06 – In Vitro Screening32-36Overview, Langendorff isolated perfused heart, Isolated rabbit aorta, Heart-lung preparation, Biochemical & histological endpoints (TTC, H&E, CK-MB, MDA, SOD)
07 – Clinical Evaluation37-40Clinical endpoints, Exercise Stress Testing (Bruce protocol), Clinical trial design (Phase I-IV), Notable trials (COURAGE, IONA, BEAUTIFUL, SIGNIFY)
08 – Comparison & Summary41-50Drug selection by angina type, Hemodynamic comparison table, Drug interactions, Special populations, ECG changes, PK summary table, Step-by-step therapy guide, Memory aids, Conclusion
Design: Deep navy + red-orange accent + amber highlights on dark background; color-coded section dividers; labeled three-column model slides (Principle / Procedure / Endpoint) for each screening method.

Create a one-page cheat sheet summarizing the 6 in vivo and 5 in vitro screening models

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Antianginal Screening Cheatsheet

PDF Document · PDF

What's on it (A4, single page, print-ready)

The sheet has two color-coded tables — one per category — each with 6 columns:
| # | Model Name | Animal/Prep | Principle | Key Procedure Steps | Endpoints |
IN VIVO (6 models) - red/orange accent numbering:
  1. Isoproterenol-induced myocardial necrosis - Rat; CK-MB, LDH, TTC
  2. LAD coronary artery occlusion-reperfusion - Rat/Rabbit; TTC infarct size, troponin
  3. Ischemic preconditioning model - Rabbit; infarct % of area at risk, KATP validation
  4. Microspheres-induced acute ischemia - Dog/Rat; regional blood flow, focal necrosis
  5. Electrical stimulation-induced coronary thrombosis - Dog/Rat; time to occlusion (TTO)
  6. Stenosis-induced coronary thrombosis - Dog; ameroid constrictor, progressive occlusion
IN VITRO (5 models) - green/teal accent numbering:
  1. Langendorff isolated perfused heart - Rat/Guinea pig; LVDP, dP/dt, coronary flow
  2. Isolated heart-lung preparation - Cat/Dog/Rabbit; cardiac output, O₂ consumption
  3. Calcium antagonism in pithed rat - Pithed rat; pA₂ value, Ca²⁺ pressor response
  4. Coronary artery ligation in isolated heart - Rat Langendorff; LDH in perfusate, TTC
  5. Isolated rabbit aorta - Rabbit rings; IC₅₀, % relaxation, endothelium-dependent/independent
A key abbreviations bar and reference footer are included at the bottom.
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