Here is the complete, stepwise breakdown of the Arruda Criteria for WPW accessory pathway (AP) localization - one of the most accurate ECG algorithms available (sensitivity ~90%, specificity ~99%).
Arruda Criteria - WPW Accessory Pathway Localization
Background
- Developed by Arruda et al. (1998) correlating 12-lead ECG with successful RF ablation sites
- Uses the initial 20 ms of delta wave polarity in leads I, II, aVF, and V1
- Delta wave classified as: Positive (+), Negative (-), or Isoelectric (+/-)
- Also uses R:S ratio in V1 and lead III
- Localizes the AP to 10 positions around the tricuspid and mitral annuli
The 4 Steps
STEP 1 - Is it a Left Free Wall Pathway?
Look at: Lead I and Lead V1
| Finding | Interpretation |
|---|
| Delta wave in Lead I is negative or isoelectric | → LEFT Free Wall pathway |
| OR R wave > S wave amplitude in V1 (R > S in V1) | → LEFT Free Wall pathway |
If either of these is present → proceed to aVF to pinpoint left side location (Step 2).
If neither → move to Step 3 (septal or right free wall).
STEP 2 - Pinpoint the Left Free Wall Pathway
Look at: Lead aVF (only if Step 1 positive)
| aVF Delta Wave | Location |
|---|
| Positive | Left Lateral / Left Anterolateral |
| Isoelectric or Negative | Left Posterior / Left Posterolateral |
Summary: Left side + aVF positive = anterolateral; aVF negative/iso = posterolateral
STEP 3 - Septal Pathways (if Step 1 negative)
Look at: Lead V1
| V1 Delta Wave | Interpretation |
|---|
| Negative or Isoelectric | → SEPTAL pathway - now check aVF |
| Positive | → RIGHT Free Wall pathway - go to Step 4 |
If V1 is Negative/Isoelectric → Check aVF:
| aVF Delta Wave | Location |
|---|
| Negative | Posteroseptal - Tricuspid annulus (right posteroseptal) |
| Isoelectric | Posteroseptal - Could be tricuspid OR mitral annulus |
| Positive | Anteroseptal / Right Anterior Paraseptal / Midseptal (tricuspid annulus) |
Tip: A "±" in aVF means you can't distinguish right vs left posteroseptal by ECG alone - EP study needed.
STEP 4 - Right Free Wall Pathway
Look at: Lead aVF (only after V1 is Positive and left side was excluded in Step 1)
| aVF Delta Wave | Proceed to... | Location |
|---|
| Positive | - | Right Anterior / Right Anterolateral |
| Isoelectric or Negative | Check Lead II | |
If aVF is Isoelectric/Negative → Check Lead II:
| Lead II Delta Wave | Location |
|---|
| Positive | Right Lateral |
| Isoelectric | Right Posterior / Right Posterolateral |
Summary Flowchart (Text Version)
START
│
├─ Lead I negative/iso OR R>S in V1?
│ YES → LEFT FREE WALL
│ aVF (+) → Left Lateral / Anterolateral
│ aVF (-/±) → Left Posterior / Posterolateral
│
│ NO ↓
│
├─ V1 negative/iso?
│ YES → SEPTAL
│ aVF (-) → Right Posteroseptal
│ aVF (±) → Right or Left Posteroseptal
│ aVF (+) → Anteroseptal / Midseptal
│
│ NO (V1 positive) → RIGHT FREE WALL
│ aVF (+) → Right Anterior / Anterolateral
│ aVF (-/±) → check Lead II
│ II (+) → Right Lateral
│ II (±) → Right Posterior / Posterolateral
10 AP Locations Identified
| # | Location | Abbreviation |
|---|
| 1 | Left Lateral / Anterolateral | LAL |
| 2 | Left Posterior / Posterolateral | LPL |
| 3 | Right Posteroseptal (tricuspid) | RPS |
| 4 | Left or Right Posteroseptal (ambiguous) | PS ± |
| 5 | Anteroseptal | AS |
| 6 | Midseptal | MS |
| 7 | Right Anterior Paraseptal | RAPS |
| 8 | Right Anterior / Anterolateral | RAL |
| 9 | Right Lateral | RL |
| 10 | Right Posterior / Posterolateral | RPL |
Key Points to Remember
- Lead I + V1 are your first filters - they split left free wall from everything else
- aVF is the most-used secondary lead - it appears in all 3 branches
- V1 negative always means septal before assuming right-sided
- The original paper used only the first 20 ms of the delta wave - not the entire QRS
- Isoelectric delta in aVF at the septal step is the one "gray zone" where ECG can't distinguish right vs left posteroseptal
- Right-sided APs tend to have wider QRS (~145 ms) than left-sided (~131 ms)
The original Arruda et al. paper is published in
PACE (1998), PMID 9475572, and remains a reference standard for pre-ablation planning.