I now have enough information from authoritative sources to give a thorough answer. Here is the complete breakdown:
Medications in This Prescription & Dental Implant Surgery
Patient: Arvind Kumar, 64 yr/M | Diagnosis: Type 2 Diabetes Mellitus | Prescriber: Dr. Akansha Tripathi, Lucknow NR Divisional Railway Hospital
🔴 MUST DISCUSS WITH DOCTOR BEFORE STOPPING OR CONTINUING
1. Aspirin 75 mg (No. 7)
Most important one to address. Aspirin irreversibly inhibits platelet cyclooxygenase, increasing bleeding risk during implant surgery. However, per the
American Dental Association guidelines,
the risks of stopping aspirin (stroke, MI, thromboembolism) generally outweigh the benefits - especially in a 64-year-old diabetic patient who is likely on it for cardiovascular protection. Do NOT stop this on your own. The implant surgeon must consult the prescribing cardiologist/physician.
- If the physician approves stopping: stop 7-10 days before surgery (Dermatology 2-Volume Set, p. Medications section)
- In most dental implant cases, local hemostatic measures are used and aspirin is continued.
2. Metformin SR 500 mg (No. 2)
Metformin should be held on the day of surgery (and the evening before if general anesthesia or significant sedation is planned), due to risk of lactic acidosis if blood pressure drops or contrast is used. For dental implant under local anesthesia, discuss with the physician - hold the morning dose on the day of surgery is a common recommendation.
3. Glimepiride 1 mg (No. 1)
This sulfonylurea causes insulin secretion regardless of food intake. Since the patient will likely be fasting before surgery, Glimepiride should be held on the morning of surgery to prevent hypoglycemia. Resume once eating normally.
4. Etoricoxib 90 mg (No. 11) - an NSAID
NSAIDs inhibit platelet aggregation and increase bleeding risk. Etoricoxib also impairs bone healing and may interfere with osseointegration (the key process for implant success). Should be stopped 5-7 days before implant surgery and not restarted for at least 2-3 weeks after.
🟡 CONTINUE BUT INFORM THE IMPLANT SURGEON
| Drug | Category | Why to Continue | Action Needed |
|---|
| Telmisartan 40 mg (ARB) | Antihypertensive | Must NOT be stopped abruptly - risk of rebound hypertension | Take as usual; surgeon must monitor BP |
| Ramipril 5 mg (ACE inhibitor) | Antihypertensive | Same as above; also risk of ACE inhibitor-related hypotension under sedation | Continue; inform surgeon |
| Atorvastatin 10 mg | Statin | Continue - may even aid bone healing | No change needed |
| Sodium Valproate 500 mg | Anticonvulsant/mood stabilizer | Never stop abruptly - seizure risk | Continue |
| Quetiapine 100 mg | Atypical antipsychotic | Continue - abrupt withdrawal causes psychiatric decompensation | Continue |
| Clonazepam 0.5 mg | Benzodiazepine | Abrupt withdrawal dangerous; may actually be used as premedication in surgery | Continue |
| Donepezil 5 mg | Cholinesterase inhibitor (for dementia/cognition) | Continue - no significant surgical risk | Inform surgeon |
🟢 TOPICAL - LOW RISK
Diclofenac Gel (No. 12): Topical application. Minimal systemic absorption. Stop applying over the surgical area, but generally safe to continue on other body parts. Discuss with surgeon.
Summary Table
| Medicine | Action Before Implant Surgery |
|---|
| Aspirin 75 mg | ⚠️ Do NOT stop without cardiology/physician approval - discuss with both doctors |
| Metformin SR 500 mg | Hold morning dose on day of surgery |
| Glimepiride 1 mg | Hold morning dose on day of surgery (fasting = hypoglycemia risk) |
| Etoricoxib 90 mg | Stop 5-7 days before surgery; may impair osseointegration |
| Telmisartan + Ramipril | Continue - inform surgeon of BP medications |
| Quetiapine, Valproate, Clonazepam | Continue - never stop abruptly |
| Donepezil, Atorvastatin | Continue |
| Diclofenac gel | Discuss with surgeon; avoid on surgical site |
Important: This patient is a 64-year-old diabetic on multiple cardiac and neuropsychiatric medications. Dental implant surgery carries a higher-than-average risk in this profile. Mandatory pre-surgical medical clearance from the prescribing physician (Dr. Akansha Tripathi) is required before proceeding. Blood glucose must be well controlled (ideally HbA1c < 8%) before elective implant surgery, as uncontrolled diabetes impairs osseointegration and wound healing significantly.