Here is the full, combined set of NTEP questions covering all three angles - Medical/Clinical, Government Scheme/Policy, and Both together - for your GPSC interview:
NTEP - Complete GPSC Interview Question Bank
Medical + Policy + Combined (All Three Angles)
PART 1 - MEDICAL / CLINICAL QUESTIONS
Q1. What is Tuberculosis (TB)? What organism causes it?
TB is a chronic infectious disease caused by Mycobacterium tuberculosis, an aerobic, acid-fast bacillus (AFB). It primarily affects the lungs (pulmonary TB) but can spread to any organ - lymph nodes, spine (Pott's disease), brain (TB meningitis), kidneys, intestines (extrapulmonary TB). It spreads via airborne droplet nuclei when an infected person coughs, sneezes, or speaks.
Q2. What are the classical symptoms of pulmonary TB?
- Cough for more than 2 weeks (most important symptom)
- Haemoptysis (blood in sputum)
- Evening rise of fever
- Night sweats
- Weight loss and loss of appetite
- Breathlessness and chest pain in advanced disease
A person with cough for 2+ weeks is called a "Presumptive TB case" under NTEP.
Q3. How is TB diagnosed under NTEP?
| Method | Details |
|---|
| Sputum Smear Microscopy | At Designated Microscopy Centres (DMC); detects AFB |
| CBNAAT (Xpert MTB/RIF) | Molecular test; detects TB + rifampicin resistance in 2 hours |
| TrueNat | Chip-based molecular test; used at peripheral levels |
| Culture & DST | Gold standard; done at Intermediate Reference Labs (IRL); takes weeks |
| Chest X-ray + AI | Screening tool; AI-assisted reading deployed in 8 states/UTs |
| FNAC / Biopsy | For extrapulmonary TB |
Q4. What is the treatment for drug-sensitive TB under NTEP?
The standard regimen is:
- Intensive Phase (2 months): HRZE - Isoniazid (H) + Rifampicin (R) + Pyrazinamide (Z) + Ethambutol (E)
- Continuation Phase (4 months): HR - Isoniazid + Rifampicin
- Total duration: 6 months for most drug-sensitive TB
- Daily dosing with Fixed Dose Combinations (FDCs) is used
- Treatment is provided FREE under NTEP
Q5. What is drug-resistant TB and its classification?
| Type | Definition |
|---|
| Mono-resistant TB | Resistant to one first-line drug |
| Poly-resistant TB | Resistant to more than one first-line drug (but not both H+R) |
| MDR-TB | Resistant to both Isoniazid (H) AND Rifampicin (R) |
| Pre-XDR TB | MDR + resistant to any fluoroquinolone |
| XDR-TB | MDR + resistant to fluoroquinolone + at least one of bedaquiline/linezolid |
MDR-TB treatment is longer (18-24 months) and uses second-line drugs including Bedaquiline, Delamanid, and Linezolid.
Q6. What is the BPaL regimen?
BPaL (Bedaquiline + Pretomanid + Linezolid) is a newer, shorter (6 months) regimen for XDR-TB and treatment-intolerant MDR-TB. It is a major advancement that reduces the treatment duration from 18-24 months to just 6 months with better outcomes.
Q7. What is TB-HIV co-infection and how is it managed?
HIV is the strongest risk factor for TB reactivation. TB is the leading cause of death in HIV-positive patients. Management principles:
- All TB patients must be tested for HIV
- All HIV patients must be screened for TB
- Both Anti-TB Treatment (ATT) and Anti-Retroviral Therapy (ART) are given together
- Cotrimoxazole preventive therapy (CPT) is added
- Coordination between NTEP and NACP (National AIDS Control Programme) is essential
Q8. What is Latent TB Infection (LTBI) and how is it managed?
LTBI is a state where a person is infected with M. tuberculosis but does not have active disease. They are not infectious. Under NTEP's prevention pillar:
- High-risk contacts of TB patients are screened
- LTBI is diagnosed by TST (Tuberculin Skin Test) or IGRA (Interferon-Gamma Release Assay)
- Isoniazid Preventive Therapy (IPT) - 6 months - is given to prevent progression to active TB
- 3HP regimen (Isoniazid + Rifapentine weekly x 3 months) is a newer option
Q9. What is the role of BCG vaccine in TB prevention?
BCG (Bacille Calmette-Guerin) is given at birth under the Universal Immunisation Programme (UIP). It provides:
- 70-80% protection against severe childhood forms of TB (miliary TB, TB meningitis)
- Does NOT reliably prevent pulmonary TB in adults
- It is the most widely used vaccine globally
- New TB vaccines are under clinical trials
Q10. What are the side effects of anti-TB drugs?
| Drug | Key Side Effect |
|---|
| Isoniazid (H) | Peripheral neuropathy (prevented by Pyridoxine/Vit B6), hepatitis |
| Rifampicin (R) | Orange-red discoloration of urine/secretions, hepatitis, enzyme inducer |
| Pyrazinamide (Z) | Hepatotoxicity, hyperuricemia (gout) |
| Ethambutol (E) | Optic neuritis (visual disturbance - check vision before starting) |
| Streptomycin (S) | Ototoxicity (hearing loss), nephrotoxicity |
PART 2 - GOVERNMENT SCHEME / POLICY QUESTIONS
Q11. What is NTEP? When and why was it renamed from RNTCP?
NTEP - National Tuberculosis Elimination Programme - was renamed from RNTCP (Revised National TB Control Programme) in 2020. The name change reflects India's shift from "controlling" TB to "eliminating" it by 2025, five years ahead of WHO's global SDG target of 2030. It is funded by the Government of India and implemented under the National Health Mission (NHM).
Q12. What is the National Strategic Plan (NSP) for TB?
The NSP 2017-2025 is India's roadmap for TB elimination. It is built on four pillars:
- Detect - Universal, rapid, early case detection
- Treat - Quality treatment, patient support, addressing social determinants
- Prevent - Infection control, LTBI treatment, vaccination
- Build - Strengthening health systems, HR, governance, research
Targets under NSP: 90% reduction in TB deaths and 80% reduction in TB incidence by 2025 vs. 2015 baseline.
Q13. What is the Pradhan Mantri TB Mukt Bharat Abhiyaan (PMTBMBA)?
Launched in September 2022 by President Droupadi Murmu, this is a flagship programme for whole-of-society and whole-of-government TB elimination. Key features:
- Introduced the Ni-kshay Mitra concept
- Promotes community, corporate, and civil society participation
- Gram Panchayats compete for TB-Free certification (Bronze/Silver/Gold)
- Under the 100-Day TB Mukt Bharat Abhiyaan (launched Dec 2024): 20 crore+ people screened, 28 lakh+ TB cases detected, 9 lakh asymptomatic cases found
- 46,118 Gram Panchayats awarded TB-free certification for 2024
Q14. What is Nikshay Poshan Yojana (NPY)?
NPY is a DBT (Direct Benefit Transfer) scheme providing Rs. 1,000 per month (updated from Rs. 500) to all notified TB patients for nutritional support throughout treatment. Key facts:
- Recognises malnutrition as a major risk factor for TB
- Transferred directly to the patient's bank account
- Covers both public and private sector TB patients
- Addresses catastrophic expenditure faced by TB-affected households
Q15. What is the Nikshay Portal?
Nikshay (Sanskrit: "Ni" = to eradicate + "Kshay" = TB disease) is India's national web-based patient management and surveillance system for TB. Functions:
- Mandatory notification of all TB cases (public and private)
- Treatment tracking and outcome monitoring
- DBT disbursement for NPY
- Ni-kshay Mitra adoption management
- Real-time data for policy decisions
- In 2024, Nikshay recorded 2.63 million TB cases
Q16. What is a Ni-kshay Mitra?
A Ni-kshay Mitra is a voluntary adopter - individual, corporate, NGO, elected representative, institution - who supports TB patients beyond government entitlements:
- Nutritional support (food baskets, meals)
- Vocational/livelihood support
- Educational support
- Psychological and social support
- Over 1 lakh Ni-kshay Mitras enrolled during the 100-Day campaign
Q17. What is Universal Drug Susceptibility Testing (UDST)?
Under NTEP, all diagnosed TB patients undergo drug sensitivity testing BEFORE starting treatment. This ensures:
- Correct drug regimen from Day 1
- Prevents amplification of drug resistance
- Rapid molecular tests (CBNAAT/TrueNat) enable UDST even at peripheral levels
Q18. What is TB-Free certification of Gram Panchayats?
Under PMTBMBA, Gram Panchayats (GPs) are certified TB-free at Bronze, Silver, and Gold levels based on indicators like:
- Active case finding coverage
- Treatment success rates
- Ni-kshay Mitra adoption rates
- Nutritional support coverage
- 46,118 GPs received TB-free certification for 2024
Q19. What is the Public-Private Mix (PPM) in NTEP?
About 50% of TB patients in India seek care from private providers first. PPM ensures:
- Mandatory notification of TB by all private providers on Nikshay
- Standard treatment protocols followed in private sector
- Government drugs and diagnostics available to private providers
- Incentives paid to private providers for notification and treatment success
- PPM coordinators stationed at districts manage this interface
Q20. What is the administrative structure of NTEP?
| Level | Unit | Head |
|---|
| National | Central TB Division (CTD), MoHFW | Deputy Director General (TB) |
| State | State TB Cell | State TB Officer (STO) |
| District | District TB Centre (DTC) | District TB Officer (DTO) |
| Sub-district | Tuberculosis Unit (TU) | Medical Officer-TB |
| Peripheral | Designated Microscopy Centre (DMC) / HWC | Lab Technician / CHO |
PART 3 - COMBINED MEDICAL + POLICY / ANALYTICAL QUESTIONS
Q21. India accounts for 26% of global TB burden yet has made good progress - explain this paradox.
India's absolute numbers remain high due to its 1.4 billion population, poverty, malnutrition, urban density, and late start in molecular diagnostics. However, proportionally India achieved:
- 21% reduction in TB incidence (237 to 187 per lakh, 2015-2024)
- Double the global average rate of decline
- 83% reduction in "missing" TB cases (from 15 lakh to 2.5 lakh)
- Treatment success rate of 90% (above global average of 88%)
- These gains come from NTEP's combination of clinical tools (CBNAAT, FDCs, new drug regimens) and policy tools (NPY, PMTBMBA, Nikshay, PPM).
Q22. How does malnutrition link to TB and what has NTEP done about it?
Malnutrition suppresses cell-mediated immunity, the key defence against M. tuberculosis. India has a dual burden - both TB and malnutrition among the poor. NTEP's response:
- Nikshay Poshan Yojana (Rs. 1,000/month DBT)
- Ni-kshay Mitras provide food baskets
- Linkage with PDS (Public Distribution System) for ration cards
- ICDS and Anganwadis for household nutrition improvement
- TB-free Panchayat certification incentivises community-level nutrition action
Q23. What are the challenges in achieving TB elimination by 2025?
| Challenge | Explanation |
|---|
| Drug resistance | 32% rise in DR-TB cases |
| Private sector gaps | Irregular treatment, no notification |
| Social determinants | Poverty, overcrowding, malnutrition |
| HIV co-infection | Accelerates TB progression |
| COVID-19 disruption | Disrupted case finding and treatment |
| Stigma | Delays healthcare seeking |
| Tribal/remote areas | Poor access to diagnostics and treatment |
| Missed cases | 2.5 lakh still undiagnosed in 2023 |
Q24. As a District Collector/Administrative Officer, how would you strengthen NTEP in your district?
This is a high-value interview question. A strong answer covers:
- Inter-departmental convergence: Health, Panchayati Raj, Education, Labour, Social Welfare, Industry
- DBT monitoring: Ensure all TB patients receive NPY payments; resolve banking bottlenecks
- Ni-kshay Mitra mobilisation: Engage industrial associations (textiles, diamonds, chemicals in Gujarat), corporates, MLAs, MPs
- TB-Free Panchayat competition: Create positive competition among GPs with recognition events
- Active case finding: Organise camps in slums, tribal areas, construction sites, prisons, and brick kilns
- PPM oversight: Ensure private providers notify cases; coordinate with IMA
- Stigma reduction: IEC campaigns through schools, panchayats, SHGs
- Data review: Chair monthly DTCS (District TB Control Society) meetings; review Nikshay data on CNR, treatment success, NPY disbursement
Q25. How does NTEP connect to India's SDG commitments?
NTEP directly addresses SDG 3.3 - "End TB epidemic by 2030." India's 2025 target is 5 years ahead of SDG timelines. TB also connects to:
- SDG 1 (No Poverty) - TB pushes families into catastrophic expenditure
- SDG 2 (Zero Hunger) - malnutrition-TB link
- SDG 10 (Reduced Inequalities) - TB disproportionately affects marginalised groups
- SDG 17 (Partnerships) - PPM, Ni-kshay Mitras, CSO partnerships
Q26. What is the significance of Gujarat in NTEP? (Gujarat-specific for GPSC)
- Gujarat is among the high-burden states listed in Nikshay data (alongside West Bengal, Delhi, Rajasthan)
- Urban TB burden is significant due to industrial cities (Ahmedabad, Surat, Vadodara) with dense migrant worker populations
- Migrant workers in diamond polishing, textile, and construction are high-risk groups
- Gujarat's industrial base is ideal for Ni-kshay Mitra mobilisation through CSR
- State TB Cell under Gujarat's Directorate of Health Services coordinates with 33 district DTCs
- Active TB screening at brick kilns and textile clusters is a Gujarat priority
Quick-Reference Data Points (Memorise These)
| Fact | Data |
|---|
| India's share of global TB burden | 26% |
| TB incidence rate (2015) | 237 per lakh |
| TB incidence rate (2024) | 187 per lakh |
| Reduction in incidence (2015-2024) | 21% (double global average) |
| TB deaths reduction | 28 to 22 per lakh (2015-2023) |
| Missing TB cases (2015 vs 2023) | 15 lakh → 2.5 lakh (83% reduction) |
| Treatment success rate | 90% (global avg: 88%) |
| Nikshay cases (2024) | 2.63 million |
| NPY amount | Rs. 1,000/month |
| NTEP renamed | 2020 |
| PMTBMBA launched | September 2022 |
| India's elimination target | 2025 (WHO global target: 2030) |
| TB-free GPs certified (2024) | 46,118 |
| 100-Day campaign screened | 20 crore+ |
| 100-Day campaign detected | 28 lakh+ (9 lakh asymptomatic) |
Best of luck for your GPSC interview! The key is to always answer with the administrative officer's lens - connect clinical knowledge to governance actions, scheme implementation, data monitoring, and inter-departmental coordination.