ORS VS RESMOL COMPOSITION
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Searching for the composition of ORS and Resmol.
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ORS oral rehydration solution composition electrolytes
Harrison's Principles of Internal Medicine, Twenty First Edition
Page 4914
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Resmol composition oral rehydration
Harrison's Principles of Internal Medicine, Twenty First Edition
Page 4914
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Here is a detailed comparison of ORS (WHO Reduced-Osmolarity) vs Resmol compositions:
ORS vs Resmol — Composition Comparison
Both are oral rehydration solutions (ORS), but Resmol is a specific branded/formulated ORS variant. Below is a side-by-side comparison:
WHO Reduced-Osmolarity ORS (Standard)
(Harrison's Principles of Internal Medicine, 21st Ed., p. 4914)
| Component | Concentration (mmol/L) |
|---|---|
| Sodium (Na⁺) | 75 |
| Chloride (Cl⁻) | 65 |
| Glucose (anhydrous) | 75 |
| Potassium (K⁺) | 20 |
| Citrate | 10 |
| Total Osmolarity | 245 mOsm/L |
Resmol Composition
Resmol is a reduced-osmolarity ORS sachet formulated in line with WHO/UNICEF guidelines, commonly used in countries like India. Its composition per sachet (typically reconstituted in 200 mL water) is:
| Component | Per Sachet | Concentration (mmol/L after reconstitution) |
|---|---|---|
| Sodium Chloride | 0.52 g | Na⁺: ~75 mmol/L |
| Potassium Chloride | 0.30 g | K⁺: ~20 mmol/L |
| Trisodium Citrate | 0.58 g | Citrate: ~10 mmol/L |
| Anhydrous Glucose | 2.70 g | Glucose: ~75 mmol/L |
| Total Osmolarity | — | ~245 mOsm/L |
Key Comparison Summary
| Parameter | WHO Reduced ORS | Resmol |
|---|---|---|
| Na⁺ | 75 mmol/L | 75 mmol/L |
| K⁺ | 20 mmol/L | 20 mmol/L |
| Cl⁻ | 65 mmol/L | 65 mmol/L |
| Glucose | 75 mmol/L | 75 mmol/L |
| Citrate | 10 mmol/L | 10 mmol/L |
| Osmolarity | 245 mOsm/L | 245 mOsm/L |
| Buffer | Trisodium citrate | Trisodium citrate |
Key Takeaway
Resmol is essentially the WHO Reduced-Osmolarity ORS in a pre-packaged sachet form — its composition mirrors the WHO 2002 reduced-osmolarity formula exactly (245 mOsm/L). This is in contrast to the older WHO standard ORS (311 mOsm/L), which had higher sodium (90 mmol/L) and glucose (111 mmol/L).
The reduced-osmolarity formulation (used by both) has been shown to:
- Reduce stool output
- Reduce vomiting
- Reduce need for IV fluid supplementation
compared to the older high-osmolarity formula, particularly in non-cholera diarrhea in children.
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