1. Differential diagnosis & management of Inguinal Bubo 2. Discuss leprosy- Clinical, bacteriological, histological, immunological features 3. (A) Esthiomene (B) HAART 4. Role of counselling in management of STI 5. (A) Newer drugs in leprosy (B) Vaccines in leprosy 6. Deformities in leprosy and their management 7. (A) Congenital Syphilis (B) Non treponemal serological test in syphilis 8. Discuss herpes genitalis 9. (A) Nerve biopsy in leprosy (B) Clofazimine 10. (A) ENL (B) OHL (Oral Hairy Leukoplakia) in 10marks format for 3rd yr dermatology post graduate theory examination

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general-purpose

You are a medical research agent. Search the medical textbook library database for content on these 5 topics related to STI/Dermatology for a 3rd year postgraduate dermatology theory exam. For each topic, find and read the relevant textbook sections. TOPICS TO RESEARCH: 1. Inguinal Bubo - differential diagnosis and management (LGV, chancroid, plague, filariasis, etc.) 2. Leprosy - complete discussion: clinical features, bacteriological features, histological features, immunological features (Ridley-Jopling classification, types, reactions) 3. (A) Esthiomene - definition, causes, clinical features, management; (B) HAART - highly active antiretroviral therapy in HIV/STI context 4. Role of counselling in management of STI 5. (A) Newer drugs in leprosy (B) Vaccines in leprosy INSTRUCTIONS: - Use query_library_db to search headings_fts and paragraphs_fts for each topic - Read relevant file sections using read_file with appropriate offsets - Extract detailed, exam-relevant information - Return comprehensive notes for each topic with all clinical details, classifications, treatment regimens, drug names, doses where available Start with these searches: ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'inguinal bubo' ORDER BY rank LIMIT 5 ``` ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'leprosy clinical features' ORDER BY rank LIMIT 5 ``` ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'esthiomene' ORDER BY rank LIMIT 5 ``` ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'counselling STI sexually transmitted' ORDER BY rank LIMIT 5 ``` ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'newer drugs leprosy vaccines' ORDER BY rank LIMIT 5 ``` Then read the relevant file sections and compile detailed notes. Return all findings as structured notes per topic.

general-purpose

You are a medical research agent. Search the medical textbook library database for content on these 5 topics related to STI/Dermatology for a 3rd year postgraduate dermatology theory exam. For each topic, find and read the relevant textbook sections. TOPICS TO RESEARCH: 6. Deformities in leprosy and their management (claw hand, foot drop, lagophthalmos, saddle nose, etc.) 7. (A) Congenital Syphilis - features, diagnosis, management; (B) Non-treponemal serological tests in syphilis (VDRL, RPR) 8. Herpes genitalis - etiology, clinical features, diagnosis, management, complications 9. (A) Nerve biopsy in leprosy - indications, technique, findings; (B) Clofazimine - pharmacology, mechanism, uses, side effects 10. (A) ENL (Erythema Nodosum Leprosum) - features, management; (B) OHL (Oral Hairy Leukoplakia) - features, diagnosis, management INSTRUCTIONS: - Use query_library_db to search headings_fts and paragraphs_fts for each topic - Read relevant file sections using read_file with appropriate offsets - Extract detailed, exam-relevant information - Return comprehensive notes for each topic with all clinical details, classifications, treatment regimens Start with these searches: ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'leprosy deformities management' ORDER BY rank LIMIT 5 ``` ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'congenital syphilis' ORDER BY rank LIMIT 5 ``` ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'herpes genitalis genital herpes' ORDER BY rank LIMIT 5 ``` ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'nerve biopsy leprosy clofazimine' ORDER BY rank LIMIT 5 ``` ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'erythema nodosum leprosum ENL oral hairy leukoplakia' ORDER BY rank LIMIT 5 ``` Then read the relevant file sections and compile detailed notes. Return all findings as structured notes per topic.

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All 10 answers are now complete. Here is a quick reference summary:

Index of Answers

QTopicKey Exam Points
1Inguinal BuboDD: LGV (groove sign), Chancroid, Syphilis, Plague; Aspirate - never incise
2LeprosyFull R-J spectrum; BI scale; Th1 vs Th2 immunity; Type 1 vs Type 2 reactions; MDT regimens
3AEsthiomeneTertiary LGV; vulvar elephantiasis; anorectal stricture; Doxycycline x 21 days
3BHAART5 drug classes; TDF+3TC+DTG first-line; IRIS; U=U principle
4STI CounsellingPre/post-test; partner notification timelines; ICTC framework; 5 C's; leprosy-specific counselling
5ANewer drugs in leprosyROM regimen; Moxifloxacin; Minocycline; Thalidomide for ENL; MDR-leprosy protocol
5BVaccines in leprosyBCG (20-80%); MIP/ICRC (65%, licensed India); SDR prophylaxis (57% at 2 years)
6Leprosy deformitiesWHO Grade 0-2; claw hand surgeries (Brand's/Fowler's); foot drop (tibialis posterior transfer); POD programme
7ACongenital SyphilisHutchinson's triad; Wimberger's sign; snuffles; Penicillin G treatment
7BNTT in SyphilisVDRL (flocculation, CSF-valid); RPR (card test); BFP causes; 4-fold titre fall = cure
8Herpes GenitalisHSV-2 > HSV-1; sacral ganglia latency; Tzanck smear; Acyclovir/Valacyclovir; suppressive therapy
9ANerve biopsySural nerve; PNL diagnosis; onion-peel perineural fibrosis (BL); Wade-Fite stain
9BClofazimineDNA binding + anti-TNF; t½ 70 days; red-brown pigmentation; crystal-storing histiocytosis
10AENLImmune complex (Type III); NEW nodules + systemic features; Thalidomide (males), Prednisolone; Clofazimine for chronic
10BOHLEBV lytic; lateral tongue; non-removable; EBER-ISH; resolves with HAART; no malignant potential
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