For an educational hospital approach, first distinguish small ketones from evolving DKA.
Scenario
- 22 years, type 1 DM
- Premeal glucose 340 mg/dL = 18.9 mmol/L
- Eating a little
- “Low ketones” should be quantified:
- Blood beta-hydroxybutyrate 0.6-1.5 mmol/L, or
- Urine ketones trace/small
Check bedside status, hydration, vitals, precipitant, and obtain VBG, electrolytes, bicarbonate, anion gap, creatinine, and serum beta-hydroxybutyrate if ketones are present. If acidosis or significant ketosis is present, use your hospital DKA pathway, usually IV insulin and fluids rather than ad hoc SC correction.
If clinically well, no acidosis, and blood ketones are 0.6-1.5 mmol/L
A commonly used type 1 diabetes sick-day protocol is:
Supplemental insulin
Give an additional 0.1 unit/kg SC of short/quick-acting insulin, on top of the patient’s usual meal carbohydrate dose.
Or, if total daily insulin dose (TDD) is known:
Additional dose = 10% of the usual TDD
Examples:
| Weight | 0.1 unit/kg supplemental insulin |
|---|
| 50 kg | 5 units |
| 60 kg | 6 units |
| 70 kg | 7 units |
| 80 kg | 8 units |
| 90 kg | 9 units |
So, for example, a stable 70 kg patient with BG 340 mg/dL and blood ketones 0.6-1.5 mmol/L would receive:
- Their usual carbohydrate meal bolus based on their insulin:carbohydrate ratio, plus
- 7 units supplemental correction insulin by this sick-day protocol,
- Plus ongoing basal insulin.
This is a protocol-derived educational example, not a replacement for the hospital’s endorsed insulin order set.
NHS sick-day guidance describes 10% of TDD for blood ketones 0.7-1.5 mmol/L, and
DAFNE sick-day rules use similar supplemental dosing for significant ketones.
Important Actrapid point
The referenced pathways usually say “quick-acting” insulin, generally rapid-acting analogues. Actrapid is soluble regular insulin:
- onset about 30 minutes
- peak about 2-3 hours
- duration about 5-7 hours
Therefore:
- Administer Actrapid about 30 minutes pre-meal if reliably eating.
- Do not stack repeat Actrapid corrections every 2 hours without senior/endocrine approval or a specific protocol, because insulin-on-board persists longer than with aspart/lispro.
- Recheck glucose and ketones in 2 hours, but use the local protocol for any further Actrapid dose. Regular insulin’s longer action should make you more cautious about redosing.
Escalate to DKA protocol / senior review if
- Blood ketones ≥1.5 mmol/L, or rising
- Urine ketones more than small/trace
- Bicarbonate low, anion gap elevated, or VBG acidemia
- Vomiting, abdominal pain, Kussmaul respiration, dehydration, drowsiness, or hemodynamic instability
- Glucose/ketones fail to improve after the initial correction
For blood ketones ≥1.5 mmol/L, some sick-day protocols use 20% of TDD or 0.2 U/kg supplemental insulin, but that level merits urgent senior review and evaluation for DKA rather than simply escalating ward correction doses. Continue basal insulin throughout unless a specific DKA infusion protocol replaces it.