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Cervical incompetence (insufficiency): A weakened internal os may dilate prematurely during pregnancy, leading to second-trimester pregnancy loss. Treatment includes cervical cerclage (a suture to reinforce the internal os).
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Cervical ectopic pregnancy: Implantation within the cervical canal below a closed internal os is a diagnostic criterion — confirmed on ultrasound showing the gestational sac below the internal os with no intrauterine pregnancy.
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Labor/Induction: Cervical assessment on ultrasound measures the internal os width and posterior cervical angle to predict readiness for labor induction.
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Stenosis: Narrowing of the internal os can cause dysmenorrhea (painful periods) and hematometra (blood accumulation in the uterus).
Here is an ultrasound image showing the internal os and cervical canal in the sagittal plane: