Here is a comprehensive guide to bee sting treatment, based on Harrison's Principles of Internal Medicine (22nd Ed., 2025) and Rosen's Emergency Medicine, supplemented with current first aid guidelines.
Bee Sting Treatment
1. Immediate First Aid (All Stings)
Remove the stinger as fast as possible. Honeybees leave behind a barbed stinger with an attached venom sac that continues pumping venom after detachment. Speed of removal matters more than method - use a fingernail, credit card edge, or blade to scrape it off sideways. Tweezers can be used too, but scraping is preferred to avoid squeezing the venom sac and releasing more venom.
- Clean the site: Wash with soap and water; disinfect the area.
- Ice pack: Apply immediately to reduce pain and slow venom spread. Use a cloth between ice and skin. Apply for 15-20 minutes, repeating each hour as needed.
- Elevate: If stung on an arm or leg, elevate the limb to reduce swelling.
- Remove jewelry/tight items near the sting before swelling begins.
(Harrison's Principles of Internal Medicine 22E, p. 3779)
2. Treating Mild to Moderate Local Reactions
Most stings cause only local pain, redness, and swelling lasting a few hours.
| Symptom | Treatment |
|---|
| Pain | Ibuprofen (400-600 mg) or acetaminophen (500-1000 mg) |
| Itching / redness | Oral antihistamine (e.g., cetirizine, diphenhydramine) |
| Skin irritation | Topical calamine lotion or hydrocortisone cream |
| Swelling | Cold pack + elevation |
Large local reactions (swelling extending several centimeters from the site, lasting 2-7 days) can be treated with:
- Ice packs
- Oral antihistamines
- NSAIDs
- A short steroid taper (e.g., oral prednisone) in significant cases
(Rosen's Emergency Medicine, p. 821)
3. Warning Signs - When to Seek Emergency Care
Call emergency services immediately if any of the following develop:
- Difficulty breathing or wheezing
- Swelling of the throat, tongue, or lips
- Dizziness, fainting, or rapid heartbeat
- Hives/urticaria spreading beyond the sting site
- Nausea, vomiting, or loss of consciousness
- Sting in the mouth or throat (risk of airway swelling)
- Multiple stings (>10 in adults, >5 in children) - even without allergy, mass envenomation can cause systemic toxicity
4. Anaphylaxis Management
Anaphylaxis is a life-threatening emergency. It typically occurs within minutes.
Step-by-step:
- Epinephrine (adrenaline) FIRST - this is the only truly life-saving drug. Use an auto-injector (EpiPen) if available: inject 0.3 mg (0.3 mL of 1:1000) intramuscularly into the outer thigh. Can repeat every 20-30 minutes if needed.
- Call 911 / emergency services immediately, even if epinephrine improves symptoms.
- Lay the patient flat (or in recovery position if unconscious). Do NOT let them sit or stand upright - this worsens hemodynamic collapse.
- H1 + H2 antihistamines (e.g., diphenhydramine + ranitidine) as adjuncts - they do NOT replace epinephrine.
- Bronchodilators (e.g., salbutamol/albuterol inhaler) for bronchospasm.
- IV epinephrine is reserved for refractory anaphylaxis in hospital settings.
- Observe for 24 hours for biphasic reactions (anaphylaxis can recur 4-12 hours after apparent resolution).
Note: Glucocorticoids (steroids) are no longer routinely recommended for acute anaphylaxis - they are too slow-acting to address immediate symptoms and do not reliably prevent biphasic reactions. (Rosen's Emergency Medicine)
5. Long-Term Prevention for High-Risk Patients
- People with a known allergy should always carry an epinephrine auto-injector and wear a medical alert bracelet.
- Venom immunotherapy (desensitization) is highly effective - repeated injections of purified bee/wasp venom build a blocking IgG antibody response and dramatically reduce the risk of future anaphylaxis. Honeybee, wasp, and yellow jacket venoms are commercially available for this purpose.
- Skin testing and venom-specific RAST (radioallergosorbent test) help identify suitable candidates for immunotherapy.
(Harrison's Principles of Internal Medicine 22E, p. 3779)
Quick Reference Summary
| Reaction Type | Key Treatment |
|---|
| Normal local sting | Remove stinger, ice, analgesics, antihistamines |
| Large local reaction | Above + oral steroids if severe |
| Anaphylaxis | Epinephrine IM immediately + call 911 |
| Multiple stings | Emergency evaluation regardless of symptoms |
| Known allergy | Carry EpiPen; consider venom immunotherapy |
US Poison Control: 1-800-222-1222 (available 24/7 for guidance)